{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:22:22Z","timestamp":1793139742861,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ijcard.2015.08.106","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:31:08Z","timestamp":1439238668000},"page":"400-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":139,"special_numbering":"C","title":["Bicuspid aortic valve aortopathy in adults: Incidence, etiology, and clinical significance"],"prefix":"10.1016","volume":"201","author":[{"given":"Hector I.","family":"Michelena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro Della","family":"Corte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth K.","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Milewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Enriquez-Sarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ijcard.2015.08.106_bb0005","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cpcardiol.2005.06.002","article-title":"The bicuspid aortic valve","volume":"30","author":"Braverman","year":"2005","journal-title":"Curr. Probl. Cardiol."},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0010","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0002-8703(28)90281-1","article-title":"Coarctation of the aorta of the adult type. II. A statistical study and historical retrospect of 200 recorded cases with autopsy, of stenosis or obliteration of the descending arch in subjects above the age of two years","volume":"3","author":"Abbott","year":"1928","journal-title":"Am. Heart J."},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0015","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/01.CIR.57.5.1022","article-title":"Dissecting aortic aneurysm associated with congenital bicuspid aortic valve","volume":"57","author":"Edwards","year":"1978","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcard.2015.08.106_bb0020","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0002-9149(84)90418-1","article-title":"Risk factors for aortic dissection: a necropsy study of 161 cases","volume":"53","author":"Larson","year":"1984","journal-title":"Am. J. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcard.2015.08.106_bb0025","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0735-1097(10)80188-3","article-title":"Dissection of the aorta associated with congenital malformation of the aortic valve","volume":"17","author":"Roberts","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.ijcard.2015.08.106_bb0030","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jama.2011.1286","article-title":"Incidence of aortic complications in patients with bicuspid aortic valves","volume":"306","author":"Michelena","year":"2011","journal-title":"JAMA"},{"issue":"25","key":"10.1016\/j.ijcard.2015.08.106_bb0035","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1161\/CIRCULATIONAHA.113.007851","article-title":"Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon)","volume":"129","author":"Michelena","year":"2014","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcard.2015.08.106_bb0040","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/S0003-4975(99)00431-2","article-title":"Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications","volume":"67","author":"Coady","year":"1999","journal-title":"Ann. Thorac. Surg."},{"issue":"2","key":"10.1016\/j.ijcard.2015.08.106_bb0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.echo.2014.11.015","volume":"28","author":"Goldstein","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"8","key":"10.1016\/j.ijcard.2015.08.106_bb0050","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0002-9149(89)90430-X","article-title":"Two-dimensional echocardiographic aortic root dimensions in normal children and adults","volume":"64","author":"Roman","year":"1989","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.ijcard.2015.08.106_bb0055","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.echo.2009.03.012","article-title":"Gender, age, and body surface area are the major determinants of ascending aorta dimensions in subjects with apparently normal echocardiograms","volume":"22","author":"Biaggi","year":"2009","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jcct.2008.08.002","article-title":"Assessment of the thoracic aorta by multidetector computed tomography: age- and sex-specific reference values in adults without evident cardiovascular disease","volume":"2","author":"Lin","year":"2008","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"issue":"3","key":"10.1016\/j.ijcard.2015.08.106_bb0065","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1067\/mva.1991.26737","volume":"13","author":"Johnston","year":"1991","journal-title":"J. Vasc. Surg."},{"issue":"13","key":"10.1016\/j.ijcard.2015.08.106_bb0070","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1161\/CIR.0b013e3181d4739e","volume":"121","author":"Hiratzka","year":"2010","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ijcard.2015.08.106_bb0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/RTI.0b013e31819f9369","article-title":"The aortic root: comparison of measurements from ECG-gated CT angiography with transthoracic echocardiography","volume":"24","author":"Ocak","year":"2009","journal-title":"J. Thorac. Imaging"},{"issue":"18","key":"10.1016\/j.ijcard.2015.08.106_bb0080","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1212\/WNL.0b013e3181dc1acf","article-title":"Screening for intracranial aneurysms in patients with bicuspid aortic valve","volume":"74","author":"Schievink","year":"2010","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ijcard.2015.08.106_bb0085","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijcard.2012.03.031","article-title":"Prevalence of bicuspid aortic valve in patients presenting with subarachnoid hemorrhage related to an intracerebral aneurysm","volume":"157","author":"Shaulov","year":"2012","journal-title":"Int. J. Cardiol."},{"issue":"23","key":"10.1016\/j.ijcard.2015.08.106_bb0090","doi-asserted-by":"crossref","first-page":"e714","DOI":"10.1161\/CIRCULATIONAHA.108.190690","volume":"118","author":"Warnes","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.08.106_bb0095","article-title":"Aortic dilatation patterns and rates in adults with bicuspid aortic valves: a comparative study with Marfan syndrome and degenerative aortopathy","volume":"19","author":"Detaint","year":"2013","journal-title":"Heart"},{"issue":"12","key":"10.1016\/j.ijcard.2015.08.106_bb0100","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jcmg.2013.07.009","article-title":"Pattern of ascending aortic dimensions predicts the growth rate of the aorta in patients with bicuspid aortic valve","volume":"6","author":"Della Corte","year":"2013","journal-title":"J. Am. Coll. Cardiol. Img."},{"issue":"12","key":"10.1016\/j.ijcard.2015.08.106_bb0105","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"issue":"21","key":"10.1016\/j.ijcard.2015.08.106_bb0110","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","article-title":"Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community","volume":"117","author":"Michelena","year":"2008","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.ijcard.2015.08.106_bb0115","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.300.11.1317","article-title":"Outcomes in adults with bicuspid aortic valves","volume":"300","author":"Tzemos","year":"2008","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.ijcard.2015.08.106_bb0120","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.amjcard.2010.07.043","article-title":"Long-term risk of aortic events following aortic valve replacement in patients with bicuspid aortic valves","volume":"106","author":"McKellar","year":"2010","journal-title":"Am. J. Cardiol."},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0125","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1161\/CIRCULATIONAHA.106.176857","volume":"114","author":"Bonow","year":"2006","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcard.2015.08.106_bb0130","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.jtcvs.2014.01.021","article-title":"Surgical treatment of bicuspid aortic valve disease: knowledge gaps and research perspectives","volume":"147","author":"Della Corte","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ijcard.2015.08.106_bb0135","article-title":"Type A aortic dissection in patients with bicuspid aortic valves: clinical and pathological comparison with tricuspid aortic valves","volume":"4","author":"Eleid","year":"2013","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.ijcard.2015.08.106_bb0140","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.athoracsur.2006.10.074","article-title":"Natural history of ascending aortic aneurysms in the setting of an unreplaced bicuspid aortic valve","volume":"83","author":"Davies","year":"2007","journal-title":"Ann. Thorac. Surg."},{"issue":"4","key":"10.1016\/j.ijcard.2015.08.106_bb0145","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1017\/S1047951103000696","article-title":"Aortic dissection in children and young adults: diagnosis, patients at risk, and outcomes","volume":"13","author":"Zalzstein","year":"2003","journal-title":"Cardiol. Young"},{"issue":"6","key":"10.1016\/j.ijcard.2015.08.106_bb0150","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1002\/clc.20383","article-title":"Aortic dissection in childhood and adolescence: an analysis of occurrences over a 10-year interval in New York State","volume":"32","author":"Fikar","year":"2009","journal-title":"Clin. Cardiol."},{"issue":"8","key":"10.1016\/j.ijcard.2015.08.106_bb0155","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jacc.2014.04.073","article-title":"A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium)","volume":"64","author":"Prakash","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.ijcard.2015.08.106_bb0160","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.amjcard.2009.05.045","article-title":"Risk of aortic root or ascending aorta complications in patients with bicuspid aortic valve with and without coarctation of the aorta","volume":"104","author":"Oliver","year":"2009","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2015.08.106_bb0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.amjcard.2010.08.061","article-title":"Frequency of cardiovascular events in women with a congenitally bicuspid aortic valve in a single community and effect of pregnancy on events","volume":"107","author":"McKellar","year":"2011","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.ijcard.2015.08.106_bb0170","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jtcvs.2010.08.055","article-title":"Fate of nonreplaced sinuses of Valsalva in bicuspid aortic valve disease","volume":"142","author":"Park","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.ijcard.2015.08.106_bb0175","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jtcvs.2010.08.086","article-title":"Should the proximal arch be routinely replaced in patients with bicuspid aortic valve disease and ascending aortic aneurysm?","volume":"142","author":"Park","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"Suppl. 1","key":"10.1016\/j.ijcard.2015.08.106_bb0180","first-page":"II329","article-title":"Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm","volume":"108","author":"Nataatmadja","year":"2003","journal-title":"Circulation"},{"issue":"15","key":"10.1016\/j.ijcard.2015.08.106_bb0185","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJM197204132861502","article-title":"Life expectancy and causes of death in the Marfan syndrome","volume":"286","author":"Murdoch","year":"1972","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 6","key":"10.1016\/j.ijcard.2015.08.106_bb0190","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.jtcvs.2010.08.053","article-title":"Replacement of the ascending aorta in bicuspid aortic valve disease: where do we draw the line?","volume":"140","author":"Sundt","year":"2010","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"4","key":"10.1016\/j.ijcard.2015.08.106_bb0195","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jacc.2003.08.054","article-title":"Characterizing the young patient with aortic dissection: results from the International Registry of Aortic Dissection (IRAD)","volume":"43","author":"Januzzi","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.ijcard.2015.08.106_bb0200","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/CIRCULATIONAHA.107.702720","article-title":"Aortic diameter > or =5.5cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD)","volume":"116","author":"Pape","year":"2007","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.ijcard.2015.08.106_bb0205","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1136\/hrt.2007.132092","article-title":"The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape","volume":"94","author":"Schaefer","year":"2008","journal-title":"Heart"},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0210","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/ejcts\/ezs137","article-title":"Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation","volume":"42","author":"Girdauskas","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.ijcard.2015.08.106_bb0215","article-title":"Acute type A aortic dissection: characteristics and outcomes comparing patients with bicuspid versus tricuspid aortic valve","volume":"15","author":"Etz","year":"2014","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"6","key":"10.1016\/j.ijcard.2015.08.106_bb0220","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.athoracsur.2013.12.090","article-title":"Aortic valve morphology determines the presentation and surgical approach to acute type A aortic dissection","volume":"97","author":"Rylski","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.ijcard.2015.08.106_bb0225","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2350-15-23","article-title":"Identification of fibrillin 1 gene mutations in patients with bicuspid aortic valve (BAV) without Marfan syndrome","volume":"15","author":"Pepe","year":"2014","journal-title":"BMC Med. Genet."},{"issue":"1","key":"10.1016\/j.ijcard.2015.08.106_bb0230","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1172\/JCI44244","article-title":"Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves","volume":"121","author":"Jain","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"17","key":"10.1016\/j.ijcard.2015.08.106_bb0235","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/ajmg.a.31872","article-title":"Familial thoracic aortic dilation and bicommissural aortic valve: a prospective analysis of natural history and inheritance","volume":"143A","author":"Loscalzo","year":"2007","journal-title":"Am. J. Med. Genet. A"},{"issue":"19 Suppl. 3","key":"10.1016\/j.ijcard.2015.08.106_bb0240","first-page":"III35","article-title":"Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions","volume":"102","author":"Keane","year":"2000","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.ijcard.2015.08.106_bb0245","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1136\/heartjnl-2012-302828","article-title":"Aortopathy and bicuspid aortic valve: haemodynamic burden is main contributor to aortic dilatation","volume":"98","author":"Kim","year":"2012","journal-title":"Heart"},{"issue":"Suppl. 1","key":"10.1016\/j.ijcard.2015.08.106_bb0250","first-page":"II291","article-title":"Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve","volume":"108","author":"Yasuda","year":"2003","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ijcard.2015.08.106_bb0255","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jcmg.2011.05.004","article-title":"4D flow CMR in assessment of valve-related ascending aortic disease","volume":"4","author":"Hope","year":"2011","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"4","key":"10.1016\/j.ijcard.2015.08.106_bb0260","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/CIRCIMAGING.113.000528","article-title":"Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type","volume":"6","author":"Bissell","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"1","key":"10.1016\/j.ijcard.2015.08.106_bb0265","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0003-4975(03)01249-9","article-title":"The congenitally bicuspid aortic valve: how does it function? Why does it fail?","volume":"77","author":"Robicsek","year":"2004","journal-title":"Ann. Thorac. Surg."},{"issue":"8","key":"10.1016\/j.ijcard.2015.08.106_bb0270","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/ehjci\/jes273","article-title":"Wall shear stress and flow patterns in the ascending aorta in patients with bicuspid aortic valves differ significantly from tricuspid aortic valves: a prospective study","volume":"14","author":"Meierhofer","year":"2013","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"4","key":"10.1016\/j.ijcard.2015.08.106_bb0275","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jacc.2012.01.072","article-title":"Imaging biomarkers of aortic disease: increased growth rates with eccentric systolic flow","volume":"60","author":"Hope","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2015.08.106_bb0280","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/CIRCIMAGING.112.973370","article-title":"Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta","volume":"5","author":"Barker","year":"2012","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"6","key":"10.1016\/j.ijcard.2015.08.106_bb0370","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/CIRCULATIONAHA.113.003026","article-title":"Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy","volume":"129","author":"Mahadevia","year":"2014","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.ijcard.2015.08.106_bb0295","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.0000027905.26586.E8","article-title":"Clinical and pathophysiological implications of a bicuspid aortic valve","volume":"106","author":"Fedak","year":"2002","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ijcard.2015.08.106_bb0300","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jtcvs.2006.10.083","article-title":"Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves","volume":"133","author":"Ikonomidis","year":"2007","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0305","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0021-9290(02)00441-4","article-title":"Cellular mechanics and gene expression in blood vessels","volume":"36","author":"Lehoux","year":"2003","journal-title":"J. Biomech."},{"issue":"19","key":"10.1016\/j.ijcard.2015.08.106_bb0375","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1056\/NEJM199405123301902","article-title":"Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome","volume":"330","author":"Shores","year":"1994","journal-title":"N. Engl. J. Med."},{"issue":"26","key":"10.1016\/j.ijcard.2015.08.106_bb0380","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1056\/NEJMoa0706585","article-title":"Angiotensin II blockade and aortic-root dilation in Marfan's syndrome","volume":"358","author":"Brooke","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.ijcard.2015.08.106_bb0345","doi-asserted-by":"crossref","first-page":"e521","DOI":"10.1161\/CIR.0000000000000031","article-title":"AHA\/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Nishimura","year":"2014","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0350","doi-asserted-by":"crossref","first-page":"S1877","DOI":"10.1016\/S0003-4975(02)04147-4","article-title":"Natural history of thoracic aortic aneurysms: indications for surgery, and surgical versus nonsurgical risks","volume":"74","author":"Elefteriades","year":"2002","journal-title":"Ann. Thorac. Surg."},{"issue":"41","key":"10.1016\/j.ijcard.2015.08.106_bb0355","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.ijcard.2015.08.106_bb0360","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jtcvs.2004.07.009","article-title":"Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?","volume":"128","author":"Borger","year":"2004","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.ijcard.2015.08.106_bb0365","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0022-5223(03)00608-1","article-title":"Relationship of aortic cross-sectional area to height ratio and the risk of aortic dissection in patients with bicuspid aortic valves","volume":"126","author":"Svensson","year":"2003","journal-title":"J. Thorac. Cardiovasc. Surg."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315303417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315303417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T02:37:01Z","timestamp":1567046221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527315303417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":67,"alternative-id":["S0167527315303417"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.08.106","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bicuspid aortic valve aortopathy in adults: Incidence, etiology, and clinical significance","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.08.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}