{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:47:20Z","timestamp":1785818840163,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P 21162-B11"],"award-info":[{"award-number":["P 21162-B11"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.ijcard.2015.08.192","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T05:21:05Z","timestamp":1441084865000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function"],"prefix":"10.1016","volume":"202","author":[{"given":"Bhavisha","family":"Bakrania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene F.","family":"Du Toit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Headrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-7893","authenticated-orcid":false,"given":"Andrew C.","family":"Bulmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2015.08.192_bb0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/01.CIR.43.1.67","article-title":"Factors influencing infarct size following experimental coronary artery occlusions","volume":"43","author":"Maroko","year":"1971","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0140-6736(12)60916-7","article-title":"Cardioprotection: chances and challenges of its translation to the clinic","volume":"381","author":"Heusch","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0015","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1124\/pr.107.06002","article-title":"Interaction of cardiovascular risk factors with myocardial ischaemia\/reperfusion injury, preconditioning, and postconditioning","volume":"59","author":"Ferdinandy","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0020","doi-asserted-by":"crossref","first-page":"H1705","DOI":"10.1152\/ajpheart.00162.2009","article-title":"Clinical cardioprotection and the value of conditioning responses","volume":"296","author":"Peart","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0025","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1476-5381.2011.01413.x","article-title":"Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration","volume":"164","author":"Bulmer","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0030","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/eci.12120","article-title":"Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome","volume":"43","author":"Wallner","year":"2013","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.plipres.2012.11.001","article-title":"Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection","volume":"52","author":"Bulmer","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0040","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2217\/14622416.9.6.703","article-title":"Pharmagenetics of Gilbert's Syndrome","author":"Strassburg","year":"2008","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0045","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.freeradbiomed.2012.03.002","article-title":"Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome","volume":"52","author":"Boon","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0050","doi-asserted-by":"crossref","first-page":"F123","DOI":"10.1152\/ajprenal.00039.2014","article-title":"Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations","volume":"307","author":"Boon","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0055","doi-asserted-by":"crossref","first-page":"H1142","DOI":"10.1152\/ajpheart.00001.2014","article-title":"Hyperbilirubinemia modulates myocardial function, aortic ejection, and ischemic stress resistance in the Gunn rat","volume":"307","author":"Bakrania","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0060","first-page":"1000218","article-title":"Endogenous tetrapyrroles influence leukocyte responses to lipopolysaccharide in human blood: pre-clinical evidence demonstrating the anti-inflammatory potential of biliverdin","volume":"5","author":"Bisht","year":"2014","journal-title":"J. Clin. Cell. Immunol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0065","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1111\/jgh.12279","article-title":"Gilbert's syndrome and the risk of death: a population-based cohort study","volume":"28","author":"Horsfall","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0070","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1161\/CIRCULATIONAHA.107.718585","article-title":"Antioxidant gene therapy for cardiovascular disease: current status and future perspectives","volume":"117","author":"Levonen","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0075","doi-asserted-by":"crossref","first-page":"e92246","DOI":"10.1371\/journal.pone.0092246","article-title":"Heme oxygenase-1 induction improves cardiac function following myocardial ischemia by reducing oxidative stress","volume":"9","author":"Issan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0080","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/1074248414524479","article-title":"Delayed remote ischemic preconditioning produces an additive cardioprotection to sevoflurane postconditioning through an enhanced heme oxygenase 1 level partly via nuclear factor erythroid 2-related factor 2 nuclear translocation","volume":"19","author":"Zhou","year":"2014","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jss.2014.03.054","article-title":"Delayed remote preconditioning induces cardioprotection: role of heme oxygenase-1","volume":"191","author":"Zhou","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0090","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0167-5273(01)00612-X","article-title":"Heme oxygenase-1 pathway is involved in delayed protection induced by heat stress against cardiac ischemia\u2013reperfusion injury","volume":"82","author":"Lu","year":"2002","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0095","doi-asserted-by":"crossref","first-page":"F778","DOI":"10.1152\/ajprenal.00215.2004","article-title":"Protective effects of exogenous bilirubin on ischemia\u2013reperfusion injury in the isolated, perfused rat kidney","volume":"288","author":"Adin","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0100","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/jpsu.2001.28816","article-title":"Effect of bilirubin in ischemia\/reperfusion injury on rat small intestine","volume":"36","author":"Ceran","year":"2001","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0105","first-page":"344","article-title":"Protective effect of bilirubin in ischemia\u2013reperfusion injury in the rat intestine","volume":"35","author":"Hammerman","year":"2002","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0110","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.tiv.2009.03.007","article-title":"Cytotoxic and apoptotic effects of single and mixed oxides of beta-sitosterol on HepG2-cells","volume":"23","author":"Koschutnig","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0115","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3109\/10715762.2012.715371","article-title":"In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles","volume":"46","author":"M\u00f6lzer","year":"2012","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mrrev.2007.05.001","article-title":"The anti-mutagenic properties of bile pigments","volume":"658","author":"Bulmer","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0125","first-page":"841","article-title":"Antioxidant activities of bile pigments","author":"Stocker","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0130","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0135","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.RES.87.5.349","article-title":"Potential antiatherogenic mechanisms of ascorbate (vitamin c) and alpha-tocopherol (vitamin E)","volume":"87","author":"Carr","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0140","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/bj2900165","article-title":"Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages","volume":"172","author":"Hazell","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphys.2014.00053","article-title":"Intraperitoneal bilirubin administration decreases infarct area in a rat coronary ischemia\/reperfusion model","volume":"5","author":"Ben-Amotz","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0150","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.2000.278.2.H643","article-title":"Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction","volume":"278","author":"Clark","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0155","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/15353702-0322805-25","article-title":"Heme oxygenase-1 and the ischemia\u2013reperfusion injury in the rat heart","volume":"228","author":"Masini","year":"2003","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0160","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1161\/01.CIR.0000016602.96363.36","article-title":"Fundamentals of reperfusion injury for the clinical cardiologist","volume":"105","author":"Verma","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0165","first-page":"244","article-title":"Unconjugated bilirubin modulates nitric oxide production via iNOS regulation","volume":"4","author":"Mazzone","year":"2010","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/qjmed\/92.5.239","article-title":"Antioxidant therapy for the prevention of cardiovascular disease","volume":"92","author":"Nuttall","year":"1999","journal-title":"Q. J. Med."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0175","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/CIRCRESAHA.116.305462","article-title":"The NHLBI-sponsored consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs","volume":"116","author":"Jones","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0180","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jacc.2011.07.054","article-title":"An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials","volume":"59","author":"Gerczuk","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0185","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/1074248411414155","article-title":"Development of an NIH consortium for preclinicAl AssESsment of CARdioprotective therapies (CAESAR): a paradigm shift in studies of infarct size limitation","volume":"16","author":"Lefer","year":"2011","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0190","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2215\/CJN.06130710","article-title":"Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients","volume":"6","author":"Chen","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ijcard.2015.08.192_bb0195","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1161\/HYPERTENSIONAHA.114.04915","article-title":"Longitudinal blood pressure control, long-term mortality, and predictive utility of serum liver enzymes and bilirubin in hypertensive patients","volume":"66","author":"McCallum","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0200","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/jama.2011.124","article-title":"Serum bilirubin and risk of respiratory disease and death","volume":"16","author":"Horsfall","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2015.08.192_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20140566","article-title":"Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases","volume":"129","author":"Wagner","year":"2015","journal-title":"Clin. Sci."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315304174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315304174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T17:50:56Z","timestamp":1738000256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527315304174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":41,"alternative-id":["S0167527315304174"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.08.192","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.08.192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}