{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:17:09Z","timestamp":1788797829238,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"A. Menarini Farmaceutica Internazionale"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.ijcard.2015.10.180","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T09:29:53Z","timestamp":1445938193000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Ranolazine reduces angina frequency and severity and improves quality of life: Observational study in patients with chronic angina under ranolazine treatment in Greece (OSCAR-GR)"],"prefix":"10.1016","volume":"205","author":[{"given":"Dimitrios","family":"Alexopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kochiadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Afthonidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Barbetseas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevas","family":"Kelembekoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiria","family":"Limberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Spanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Triantafyllidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2015.10.180_bb0005","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: a systematic analysis for the global burden of disease study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.10.180_bb0010","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.10.180_bb0015","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1161\/CIR.0b013e31828124ad","article-title":"Heart disease and stroke statistics\u20132013 update: a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.10.180_bb0020","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/eurheartj\/ehl001","article-title":"Guidelines on the management of stable angina pectoris: executive summary: the task force on the management of stable angina pectoris of the European society of cardiology","volume":"27","author":"Fox","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0025","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2147\/VHRM.S2841","article-title":"Utility of ranolazine in chronic stable angina patients","volume":"4","author":"Patel","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0030","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.yjmcc.2006.08.012","article-title":"Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts","volume":"41","author":"Fraser","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0035","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/FJC.0b013e3181a1b9e7","article-title":"A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine","volume":"54","author":"Maier","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40265-012-0005-z","article-title":"Ranolazine: a review of its use as add-on therapy in patients with chronic stable angina pectoris","volume":"73","author":"Keating","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.ijcard.2015.10.180_bb0045","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jacc.2010.04.042","article-title":"The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease","volume":"56","author":"Stone","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/jama.291.3.309","article-title":"Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial","volume":"291","author":"Chaitman","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2015.10.180_bb0055","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jacc.2003.11.045","article-title":"Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina","volume":"43","author":"Chaitman","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0060","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.amjcard.2004.09.025","article-title":"Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris","volume":"95","author":"Rousseau","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0065","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jacc.2006.05.044","article-title":"Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (efficacy of ranolazine in chronic angina) trial","volume":"48","author":"Stone","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0070","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.amjcard.2013.11.070","article-title":"The usefulness of ranolazine for the treatment of refractory chronic stable angina pectoris as determined from a systematic review of randomized controlled trials","volume":"113","author":"Banon","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0075","unstructured":"European Medicines Agency. Ranexa : EPAR - Product Information. Available at : http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/000805\/WC500045937.pdf (accessed July 26, 2014)."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0080","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events v4.0. NCI, NIH, DHHS. May 29, 2009. NIH publication # 09\u20137473"},{"key":"10.1016\/j.ijcard.2015.10.180_bb0085","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.jacc.2013.02.011","article-title":"Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (type 2 diabetes evaluation of ranolazine in subjects with chronic stable angina)","volume":"61","author":"Kosiborod","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0090","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ijcard.2013.08.131","article-title":"Effects of ranolazine in symptomatic patients with stable coronary artery disease. A systematic review and meta-analysis","volume":"169","author":"Savarese","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0095","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMoa011858","article-title":"Exercise capacity and mortality among men referred for exercise testing","volume":"346","author":"Myers","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0100","first-page":"305","article-title":"Prospective validity of measuring angina severity with Canadian cardiovascular society class: the ACRE study","volume":"20","author":"Hemingway","year":"2004","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0105","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1016\/S0828-282X(09)70506-9","article-title":"Assessment of activity status and survival according to the Canadian cardiovascular society angina classification","volume":"25","author":"Kaul","year":"2009","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCOUTCOMES.108.798009","article-title":"Effects of ranolazine on disease-specific health status and quality of life among patients with acute coronary syndromes: results from the MERLIN-TIMI 36 randomized trial","volume":"1","author":"Arnold","year":"2008","journal-title":"Circ. Cardiovasc. Qual. Outcomes."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.amjcard.2013.02.045","article-title":"Effects of ivabradine and ranolazine in patients with microvascular angina pectoris","volume":"112","author":"Villano","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.10.180_bb0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s40268-013-0026-4","article-title":"Ranolazine reduces patient-reported angina severity and frequency and improves quality of life in selected patients with chronic angina","volume":"13","author":"Muhlestein","year":"2013","journal-title":"Drugs R D."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315307439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315307439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T06:55:59Z","timestamp":1537253759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527315307439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":24,"alternative-id":["S0167527315307439"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.10.180","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ranolazine reduces angina frequency and severity and improves quality of life: Observational study in patients with chronic angina under ranolazine treatment in Greece (OSCAR-GR)","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.10.180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}