{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:56:36Z","timestamp":1788918996322,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PASMP3-136995"],"award-info":[{"award-number":["PASMP3-136995"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PASMP3-136995"],"award-info":[{"award-number":["PASMP3-136995"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union"},{"name":"Cardiovascular Research Foundation Basel"},{"name":"University Hospital Basel"},{"name":"Abbott"},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nanosphere"},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]},{"name":"8sense"},{"name":"B\u00fchlmann"},{"name":"Brahms"},{"name":"Professor Max Cloetta Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ijcard.2016.01.112","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T12:25:36Z","timestamp":1452515136000},"page":"238-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"special_numbering":"C","title":["Characterization of the observe zone of the ESC 2015 high-sensitivity cardiac troponin 0 h\/1 h-algorithm for the early diagnosis of acute myocardial infarction"],"prefix":"10.1016","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2173-5738","authenticated-orcid":false,"given":"Thomas","family":"Nestelberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Wildi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Boeddinghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rubini","family":"Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Puelacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0433-6583","authenticated-orcid":false,"given":"Karin","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Sabti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hillinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Kozhuharov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0806-1786","authenticated-orcid":false,"given":"Jeanne","family":"du Fay de Lavallaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina","family":"Pinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d2scar","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Bingisser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Lohrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.01.112_bb0005","article-title":"National Hospital Ambulatory Medical Care Survey: 2007 emergency department summary","volume":"1\u201331","author":"Niska","year":"2010","journal-title":"Natl. Health Stat. Rep."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0010","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/j.jacc.2013.01.014","article-title":"2012 ACCF\/AHA focused update incorporated into the ACCF\/AHA 2007 guidelines for the management of patients with unstable angina\/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation\/American Heart Association Ta","volume":"61","author":"Anderson","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0015","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/eurheartj\/ehr236","article-title":"ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the task force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevatio","volume":"32","author":"Hamm","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0020","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1093\/eurheartj\/ehm355","article-title":"Universal definition of myocardial infarction","volume":"28","author":"Thygesen","year":"2007","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0025","series-title":"Early diagnosis of myocardial infarction with sensitive cardiac troponin assays","author":"Reichlin","year":"2009"},{"key":"10.1016\/j.ijcard.2016.01.112_bb0030","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1016\/j.ijcard.2013.07.078","article-title":"Serial changes in high-sensitivity cardiac troponin I in the early diagnosis of acute myocardial infarction","volume":"168","author":"Wildi","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0035","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1056\/NEJMoa0903515","article-title":"Sensitive troponin I assay in early diagnosis of acute myocardial infarction","volume":"361","author":"Keller","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0040","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.amjmed.2015.01.046","article-title":"One-hour rule-in and rule-out of acute myocardial infarction using High-sensitivity cardiac troponin I","volume":"128","author":"Rubini Gimenez","year":"2015","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0045","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1001\/archinternmed.2012.3698","article-title":"One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T","volume":"172","author":"Reichlin","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0050","doi-asserted-by":"crossref","first-page":"E243","DOI":"10.1503\/cmaj.141349","article-title":"Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay","volume":"187","author":"Reichlin","year":"2015","journal-title":"CMAJ"},{"key":"10.1016\/j.ijcard.2016.01.112_bb0055","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jacc.2013.02.078","article-title":"Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome","volume":"62","author":"Cullen","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0060","doi-asserted-by":"crossref","first-page":"369-79.e4","DOI":"10.1016\/j.amjmed.2014.10.032","article-title":"Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T","volume":"128","author":"Reichlin","year":"2015","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","volume":"37","author":"Authors\/Task Force Members","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0070","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1016\/j.ijcard.2013.06.049","article-title":"Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin","volume":"168","author":"Rubini Gim\u00e9nez","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0075","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jacc.2011.06.026","article-title":"Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay","volume":"58","author":"Body","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0080","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.jacc.2014.03.017","article-title":"Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction","volume":"63","author":"Bandstein","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0085","doi-asserted-by":"crossref","first-page":"h15","DOI":"10.1136\/bmj.h15","article-title":"Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis","volume":"350","author":"Zhelev","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.ijcard.2016.01.112_bb0090","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.rcl.2014.11.007","article-title":"Cardiac computed tomography for the evaluation of the acute chest pain syndrome: state of the art","volume":"53","author":"Schlett","year":"2015","journal-title":"Radiol. Clin. N. Am."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0095","first-page":"2369","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the heart","volume":"31","author":"Wijns","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0100","first-page":"933","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the heart","volume":"10","author":"Dickstein","year":"2008","journal-title":"Eur. J. Hear. Fail. J. Work. Gr. Hear. Fail. Eur. Soc. Cardiol."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1161\/CIRCULATIONAHA.112.100867","article-title":"High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease","volume":"126","author":"Haaf","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.01.112_bb0110","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1093\/eurheartj\/ehs154","article-title":"How to use high-sensitivity cardiac troponins in acute cardiac care","volume":"33","author":"Thygesen","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCULATIONAHA.111.023937","article-title":"Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction","volume":"124","author":"Reichlin","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.01.112_bb0120","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1373\/clinchem.2009.140616","article-title":"Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay","volume":"56","author":"Vasile","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1373\/clinchem.2008.107391","article-title":"Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice","volume":"55","author":"Wu","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0130","series-title":"Sensitive troponin I assay in early diagnosis of acute myocardial infarction","author":"Keller","year":"2009"},{"key":"10.1016\/j.ijcard.2016.01.112_bb0135","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1373\/clinchem.2008.114728","article-title":"Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events","volume":"55","author":"Apple","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0140","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1373\/clinchem.2011.171496","article-title":"Troponin T percentiles from a random population sample, emergency room patients and patients with myocardial infarction","volume":"58","author":"Hammarsten","year":"2012","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0145","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1515\/cclm-2011-0540","article-title":"Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population","volume":"50","author":"Koerbin","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0150","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1373\/clinchem.2008.116020","article-title":"Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury","volume":"55","author":"Kavsak","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0155","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1373\/clinchem.2009.132654","article-title":"Analytical validation of a high-sensitivity cardiac troponin T assay","volume":"56","author":"Giannitsis","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0160","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1373\/clinchem.2011.171827","article-title":"Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome","volume":"58","author":"Mueller","year":"2012","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0170","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jcct.2014.06.002","article-title":"SCCT guidelines on the use of coronary computed tomographic angiography for patients presenting with acute chest pain to the emergency department : a report of the Society of Cardiovascular Computed Tomography Guidelines Committee.","volume":"8","author":"Raff","year":"2014","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"10.1016\/j.ijcard.2016.01.112_bb0175","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/eurheartj\/ehp457","article-title":"Chronic nitrate therapy is associated with different presentation and evolution of acute coronary syndromes: insights from 52,693 patients in the Global Registry of Acute Coronary Events","volume":"31","author":"Ambrosio","year":"2010","journal-title":"Eur. Heart J."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316300997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316300997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:36:16Z","timestamp":1759091776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316300997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":35,"alternative-id":["S0167527316300997"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.01.112","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the observe zone of the ESC 2015 high-sensitivity cardiac troponin 0h\/1h-algorithm for the early diagnosis of acute myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.01.112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}