{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:52:55Z","timestamp":1792144375358,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2006A36001001"],"award-info":[{"award-number":["2006A36001001"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ijcard.2016.04.078","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T02:07:37Z","timestamp":1460686057000},"page":"263-268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Glycemic variability is an important risk factor for cardiovascular autonomic neuropathy in newly diagnosed type 2 diabetic patients"],"prefix":"10.1016","volume":"215","author":[{"given":"Wen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoda","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.04.078_bb0005","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2337\/diacare.26.6.1895","article-title":"The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis","volume":"26","author":"Maser","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0010","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0015","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1161\/CIRCULATIONAHA.108.837369","article-title":"Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the diabetes control and complications trial\/epidemiology of diabetes interventions and complications study (DCCT\/EDIC)","volume":"119","author":"Pop-Busui","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0020","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1530\/EJE-09-0710","article-title":"New insights in diabetic autonomic neuropathy in children and adolescents","volume":"161","author":"Verrotti","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0025","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1590\/S0066-782X2008000400014","article-title":"Diabetic cardiovascular autonomic neuropathy: risk factors, clinical impact and early diagnosis","volume":"90","author":"Rolim","year":"2008","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCULATIONAHA.106.634949","article-title":"Diabetic cardiovascular autonomic neuropathy","volume":"115","author":"Vinik","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0035","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1210\/jc.2005-1005","article-title":"Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study","volume":"91","author":"Cavalot","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1475-2840-10-19","article-title":"Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes","volume":"10","author":"Su","year":"2011","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0045","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.diabet.2008.04.005","article-title":"Can glycaemic variability, as calculated from blood glucose self-monitoring, predict the development of complications in type 1 diabetes over a decade?","volume":"34","author":"Bragd","year":"2008","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0050","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4093\/dmj.2012.36.1.64","article-title":"Clinical significance of the presence of autonomic and vestibular dysfunction in diabetic patients with peripheral neuropathy","volume":"36","author":"Kim","year":"2012","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0055","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1089\/dia.2008.0132","article-title":"Interpretation of continuous glucose monitoring data: glycemic variability and quality of glycemic control","volume":"11 Suppl 1","author":"Rodbard","year":"2009","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.numecd.2010.07.005","article-title":"Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy","volume":"21","author":"Spallone","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0065","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0008-6363(97)00040-0","article-title":"Effects of physical training on heart rate variability in diabetic patients with various degrees of cardiovascular autonomic neuropathy","volume":"34","author":"Howorka","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0070","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1056\/NEJMoa021778","article-title":"Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes","volume":"348","author":"Gaede","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0891-6632(91)90002-7","article-title":"Prevalence of peripheral and autonomic neuropathy in newly diagnosed type II (noninsulin-dependent) diabetes","volume":"5","author":"Ratzmann","year":"1991","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0080","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s001250050773","article-title":"Divergent development of autonomic and peripheral somatic neuropathies in NIDDM","volume":"40","author":"Toyry","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0085","doi-asserted-by":"crossref","first-page":"878760","DOI":"10.1155\/2012\/878760","article-title":"Cardiac autonomic imbalance in newly diagnosed and established diabetes is associated with markers of adipose tissue inflammation","volume":"2012","author":"Lieb","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-925X-8-3","article-title":"Identifying diabetic patients with cardiac autonomic neuropathy by heart rate complexity analysis","volume":"8","author":"Khandoker","year":"2009","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0095","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"Patel","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0100","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2337\/db07-1618","article-title":"Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial\u2014revisited","volume":"57","author":"Lachin","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0105","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2337\/dc11-0034","article-title":"Impact of glycemic and blood pressure variability on surrogate measures of cardiovascular outcomes in type 2 diabetic patients","volume":"34","author":"Di Flaviani","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0110","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00125-009-1473-x","article-title":"Glucose variability does not contribute to the development of peripheral and autonomic neuropathy in type 1 diabetes: data from the DCCT","volume":"52","author":"Siegelaar","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0115","first-page":"S4","volume":"36 Suppl 1","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0120","doi-asserted-by":"crossref","first-page":"956","DOI":"10.2337\/diacare.28.4.956","article-title":"Diabetic neuropathies: a statement by the American Diabetes Association","volume":"28","author":"Boulton","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10286-010-0084-4","article-title":"Oxidative stress and autonomic nerve function in early type 1 diabetes","volume":"21","author":"Hoeldtke","year":"2011","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0130","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1253\/circj.CJ-09-0402","article-title":"Fluvastatin attenuates diabetes-induced cardiac sympathetic neuropathy in association with a decrease in oxidative stress","volume":"74","author":"Matsuki","year":"2010","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0135","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/dmrr.613","article-title":"Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction","volume":"22","author":"Piconi","year":"2006","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0140","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/s00125-009-1304-0","article-title":"Rapid 'glycaemic swings' induce nitrosative stress, activate poly(ADP-ribose) polymerase and impair endothelial function in a rat model of diabetes mellitus","volume":"52","author":"Horvath","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0145","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00125-007-0842-6","article-title":"Glucose fluctuations and activation of oxidative stress in patients with type 1 diabetes","volume":"51","author":"Wentholt","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0150","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1001\/jama.295.14.1681","article-title":"Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes","volume":"295","author":"Monnier","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0155","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2337\/db08-0063","article-title":"Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients","volume":"57","author":"Ceriello","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0160","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0165","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/dmrr.962","article-title":"Integrating glycaemic variability in the glycaemic disorders of type 2 diabetes: a move towards a unified glucose tetrad concept","volume":"25","author":"Monnier","year":"2009","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0170","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.12659\/MSM.881318","article-title":"Establishment of normal reference ranges for glycemic variability in Chinese subjects using continuous glucose monitoring","volume":"17","author":"Zhou","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ijcard.2016.04.078_bb0175","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2337\/dc08-1956","article-title":"Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents","volume":"32","author":"Kohnert","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2016.04.078_bb0180","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.diabet.2006.11.007","article-title":"Continuous glucose monitoring in patients with type 2 diabetes: why? When? Whom?","volume":"33","author":"Monnier","year":"2007","journal-title":"Diabetes Metab."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316307938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316307938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T08:49:18Z","timestamp":1716022158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316307938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":36,"alternative-id":["S0167527316307938"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.04.078","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycemic variability is an important risk factor for cardiovascular autonomic neuropathy in newly diagnosed type 2 diabetic patients","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.04.078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}