{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:49:26Z","timestamp":1777312166626,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ijcard.2016.04.186","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T10:03:12Z","timestamp":1462442592000},"page":"190-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["The effect of losartan on progressive aortic dilatation in patients with Marfan's syndrome: a meta-analysis of prospective randomized clinical trials"],"prefix":"10.1016","volume":"217","author":[{"given":"Linggen","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiru","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.04.186_bb0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/352337a0","article-title":"Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene","volume":"352","author":"Dietz","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0010","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nature10145","article-title":"Lessons on the pathogenesis of aneurysm from heritable conditions","volume":"473","author":"Lindsay","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0015","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","article-title":"Revised diagnostic criteria for the Marfan syndrome","volume":"62","author":"De Paepe","year":"1996","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0020","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0025","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1056\/NEJM199405123301902","article-title":"Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome","volume":"330","author":"Shores","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0030","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijcard.2005.11.116","article-title":"The effect of beta-blocker therapy on clinical outcome in patients with Marfan's syndrome: a meta-analysis","volume":"114","author":"Gersony","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0035","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1111\/j.1651-2227.2011.02293.x","article-title":"The effect of beta-blocker therapy on progressive aortic dilatation in children and adolescents with Marfan's syndrome: a meta-analysis","volume":"100","author":"Gao","year":"2011","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0045","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","article-title":"Atenolol versus losartan in children and young adults with Marfan's syndrome","volume":"371","author":"Lacro","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/CIRCGENETICS.114.000950","article-title":"Beneficial outcome of losartan therapy depends on type of FBN1 mutation in Marfan syndrome","volume":"8","author":"Franken","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0055","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.mayocp.2012.11.005","article-title":"Losartan added to beta-blockade therapy for aortic root dilation in Marfan syndrome: a randomized, open-label pilot study","volume":"88","author":"Chiu","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0060","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/eurheartj\/eht334","article-title":"Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial","volume":"34","author":"Groenink","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0065","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/eurheartj\/ehv151","article-title":"Marfan Sartan: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Milleron","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0070","article-title":"Efficacy of losartan vs. atenolol for the prevention of aortic dilation in Marfan syndrome: a randomized clinical trial","author":"Forteza","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0075","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0080","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0085","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/mva.2002.121308","volume":"35","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0090","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/archsurg.1988.01400290092015","article-title":"Effect of beta-adrenergic blockade on the growth rate of abdominal aortic aneurysms","volume":"123","author":"Leach","year":"1988","journal-title":"Arch. Surg."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0095","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJMc1500128","article-title":"Atenolol versus Losartan in Marfan's syndrome","volume":"372","author":"Ziganshin","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0100","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0895-7061(99)00152-1","article-title":"Angiotensin II upregulates transforming growth factor-beta type I receptor on rat vascular smooth muscle cells","volume":"13","author":"Fukuda","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.1192152","article-title":"Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism","volume":"332","author":"Habashi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0110","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1192149","article-title":"Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice","volume":"332","author":"Holm","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0115","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1056\/NEJMoa0706585","article-title":"Angiotensin II blockade and aortic-root dilation in Marfan's syndrome","volume":"358","author":"Brooke","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0120","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1017\/S1047951112001412","article-title":"A systematic review of the pharmacological management of aortic root dilation in Marfan syndrome","volume":"23","author":"Thakur","year":"2013","journal-title":"Cardiol. Young"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0125","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/jama.298.13.1539","article-title":"Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial","volume":"298","author":"Ahimastos","year":"2007","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0130","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2459\/JCM.0b013e3283232a45","article-title":"Rationale and design of a trial evaluating the effects of losartan vs. nebivolol vs. the association of both on the progression of aortic root dilation in Marfan syndrome with FBN1 gene mutations","volume":"10","author":"Gambarin","year":"2009","journal-title":"J. Cardiovasc. Med. (Hagerstown)"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.acvd.2010.04.008","article-title":"Rationale and design of a randomized clinical trial (Marfan Sartan) of angiotensin II receptor blocker therapy versus placebo in individuals with Marfan syndrome","volume":"103","author":"Detaint","year":"2010","journal-title":"Arch. Cardiovasc. Dis."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1745-6215-11-3","article-title":"Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial","volume":"11","author":"Radonic","year":"2010","journal-title":"Trials"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0145","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijcard.2010.12.070","article-title":"The Ghent Marfan Trial\u2014a randomized, double-blind placebo controlled trial with losartan in Marfan patients treated with beta-blockers","volume":"157","author":"Moberg","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0150","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ahj.2007.06.024","article-title":"Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome","volume":"154","author":"Lacro","year":"2007","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0155","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.recesp.2011.02.009","article-title":"Study of the efficacy and safety of losartan versus atenolol for aortic dilation in patients with Marfan syndrome","volume":"64","author":"Forteza","year":"2011","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0160","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ajmg.1320280318","article-title":"The bingo model of survivorship. V. The problems of conformation to the empirical evidence","volume":"28","author":"Murphy","year":"1987","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0165","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.athoracsur.2005.06.026","article-title":"Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms","volume":"81","author":"Davies","year":"2006","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0170","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0002-9149(89)90430-X","article-title":"Two-dimensional echocardiographic aortic root dimensions in normal children and adults","volume":"64","author":"Roman","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0175","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jama.1989.03430040095032","article-title":"Association of mitral valve prolapse and systemic abnormalities of connective tissue. A phenotypic continuum","volume":"262","author":"Glesby","year":"1989","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.ijcard.2016.04.186_bb0180","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1152\/japplphysiol.01144.2004","article-title":"Theoretical and empirical derivation of cardiovascular allometric relationships in children","volume":"99","author":"Sluysmans","year":"2005","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.ijcard.2016.04.186_bb0185","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/hrt.75.4.389","article-title":"Aortic root complications in Marfan's syndrome: identification of a lower risk group","volume":"75","author":"Legget","year":"1996","journal-title":"Heart"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316308828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316308828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T08:26:39Z","timestamp":1536740799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316308828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":37,"alternative-id":["S0167527316308828"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.04.186","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of losartan on progressive aortic dilatation in patients with Marfan's syndrome: a meta-analysis of prospective randomized clinical trials","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.04.186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}