{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T07:13:04Z","timestamp":1771744384941,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ijcard.2016.06.339","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T04:37:10Z","timestamp":1467779830000},"page":"1067-1072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Acute heart failure in the young: Clinical characteristics and biomarker profiles"],"prefix":"10.1016","volume":"221","author":[{"given":"Jasper","family":"Tromp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Mentz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard C.","family":"Dittrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Teerlink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gad","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Davison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Givertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Bloomfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J.","family":"van Veldhuisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans L.","family":"Hillege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.06.339_bb0005","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa020265","article-title":"Long-term trends in the incidence of and survival with heart failure","volume":"347","author":"Levy","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0010","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cardfail.2015.05.013","article-title":"Heart failure in non-Caucasians, women, and older adults: a white paper on special populations from the Heart Failure Society of America Guideline Committee","volume":"21","author":"Colvin","year":"2015","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cardfail.2014.12.012","article-title":"Acute heart failure in the elderly: differences in clinical characteristics, outcomes, and prognostic factors in the VERITAS Study","volume":"21","author":"Metra","year":"2015","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/ejhf.207","article-title":"Acute heart failure in elderly patients: worse outcomes and differential utility of standard prognostic variables. Insights from the PROTECT trial","volume":"17","author":"Metra","year":"2015","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0025","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2013.05.072","article-title":"Clinical characteristics and outcomes of young and very young adults with heart failure: the CHARM programme (Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity)","volume":"62","author":"Wong","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0030","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/eurheartj\/ehu216","article-title":"Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)","volume":"35","author":"Wong","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0035","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/eurjhf\/hfr116","article-title":"Clinical characteristics and major comorbidities in heart failure patients more than 85years of age compared with younger age groups","volume":"13","author":"Mogensen","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0040","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.105.541078","article-title":"Age- and gender-related ventricular-vascular stiffening: a community-based study","volume":"112","author":"Redfield","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.06.339_bb0045","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.jacc.2013.06.022","article-title":"Heart failure in the young\u2217","volume":"62","author":"Voors","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0050","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the heart","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0055","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa0912613","article-title":"Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure","volume":"363","author":"Massie","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cardfail.2009.10.025","article-title":"Design and rationale of the PROTECT study: a placebo-controlled randomized study of the selective A1 adenosine receptor antagonist Rolofylline for patients hospitalized with acute decompensated heart failure and volume overload to assess treatment effect","volume":"16","author":"Weatherley","year":"2010","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0065","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.jacc.2010.11.057","article-title":"Effects of the adenosine A1 receptor antagonist Rolofylline on renal function in patients with acute heart failure and renal dysfunction","volume":"57","author":"Voors","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0070","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cardfail.2012.05.007","article-title":"The diversity of heart failure in a hospitalized population: the role of age","volume":"18","author":"Stein","year":"2012","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1001\/archinte.1989.00390050029006","article-title":"Age-related hemodynamic, renal, and hormonal differences among patients with congestive heart failure","volume":"149","author":"Cody","year":"1989","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0080","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/eurheartj\/ehs444","article-title":"Clinical course and predictive value of congestion during hospitalization in patients admitted for worsening signs and symptoms of heart failure with reduced ejection fraction: findings from the EVEREST trial","volume":"34","author":"Ambrosy","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0090","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.jacc.2014.08.036","article-title":"Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction","volume":"64","author":"Mentz","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0095","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrcardio.2014.83","article-title":"The pathophysiology of heart failure with preserved ejection fraction","volume":"11","author":"Borlaug","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0100","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/CIRCULATIONAHA.110.979203","article-title":"Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community","volume":"124","author":"Lam","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.06.339_bb0105","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.12.045","article-title":"Inflammatory markers and incident heart failure risk in older adults: the Health ABC (health, aging, and body composition) study","volume":"55","author":"Kalogeropoulos","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/CIRCHEARTFAILURE.108.770834","article-title":"Blood urea nitrogen and serum creatinine: not married in heart failure","volume":"1","author":"Schrier","year":"2008","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0115","first-page":"65","article-title":"Fractional excretion of sodium predicts worsening renal function in acute decompensated heart failure","volume":"15","author":"Alattar","year":"2010","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCHEARTFAILURE.113.000242","article-title":"Prognostic value of plasma neutrophil gelatinase-associated lipocalin for mortality in patients with heart failure","volume":"7","author":"van Deursen","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4137\/BMI.S11479","article-title":"Urine biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) have different patterns in heart failure exacerbation","volume":"8","author":"Park","year":"2013","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.ijcard.2016.06.339_bb0130","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/eurjhf\/hfr087","article-title":"Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation along with B-type NaTriuretic peptide in acutely decompensated heart failure (GALLANT) trial","volume":"13","author":"Maisel","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0135","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1161\/ATVBAHA.109.190553","article-title":"Differential associations between soluble cellular adhesion molecules and atherosclerosis in the Dallas Heart Study: a distinct role for soluble endothelial cell-selective adhesion molecule","volume":"29","author":"Rohatgi","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/ATVBAHA.113.301806","article-title":"Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study","volume":"34","author":"Park","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0145","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.lungcan.2011.01.011","article-title":"Mesothelin and kidney function\u2014analysis of relationship and implications for mesothelioma screening","volume":"73","author":"Boudville","year":"2011","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijcard.2016.06.339_bb0150","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1111\/j.1538-7836.2006.01995.x","article-title":"Angiogenin: a review of the pathophysiology and potential clinical applications","volume":"4","author":"Tello-Montoliu","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0155","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/ATVBAHA.108.179663","article-title":"Vascular endothelial growth factor","volume":"29","author":"Ferrara","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0160","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/cvr\/cvq321","article-title":"Up-regulation of soluble vascular endothelial growth factor receptor-1 prevents angiogenesis in hypertrophied myocardium","volume":"89","author":"Kaza","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2016.06.339_bb0165","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.111.246116","article-title":"Effects of aging on angiogenesis","volume":"110","author":"Lahteenvuo","year":"2012","journal-title":"Circ. Res."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316310890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316310890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T18:20:30Z","timestamp":1536603630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316310890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":33,"alternative-id":["S0167527316310890"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.06.339","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute heart failure in the young: Clinical characteristics and biomarker profiles","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.06.339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}