{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:18:07Z","timestamp":1789172287316,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ijcard.2016.07.072","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T04:30:37Z","timestamp":1467779437000},"page":"406-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Effects of late exercise on cardiac remodeling and myocardial calcium handling proteins in rats with moderate and large size myocardial infarction"],"prefix":"10.1016","volume":"221","author":[{"given":"Daniele M.","family":"Guizoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio A.","family":"Oliveira-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-7621","authenticated-orcid":false,"given":"Sefora L.R.","family":"Noor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana U.","family":"Pagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula F.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3119-5723","authenticated-orcid":false,"given":"Aline R.R.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana J.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo L.","family":"Damatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo D.M.","family":"Cezar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo A.M.","family":"Zornoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katashi","family":"Okoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina P.","family":"Okoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.07.072_bb0005","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/CIR.0000000000000350","article-title":"American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0010","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIR.0b013e31829e8807","article-title":"2013 ACCF\/AHA guideline for the management of heart failure. Executive summary: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0015","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1152\/japplphysiol.01154.2010","article-title":"Echocardiographic detection of congestive heart failure in postinfarction rats","volume":"111","author":"Martinez","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijcard.2011.06.068","article-title":"Critical infarct size to induce ventricular remodeling, cardiac dysfunction and heart failure in rats","volume":"151","author":"Minicucci","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052764","article-title":"Exercise training restores cardiac protein quality control in heart failure","volume":"7","author":"Campos","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/01.CIR.89.1.402","article-title":"Effect of endurance training early or late after coronary artery occlusion on left ventricular remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction","volume":"89","author":"Gaudron","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0035","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/eurheartj\/ehq244","article-title":"Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality","volume":"32","author":"Jorge","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0040","doi-asserted-by":"crossref","first-page":"876","DOI":"10.6061\/clinics\/2013(06)24","article-title":"Aerobic exercise improves the inflammatory profile correlated with cardiac remodeling and function in chronic heart failure rats","volume":"68","author":"Nunes","year":"2013","journal-title":"Clinics"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0045","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1440-1681.2008.05070.x","article-title":"Swimming training attenuates remodeling, contractile dysfunction and congestive heart failure in rats with moderate and large myocardial infarctions","volume":"36","author":"Portes","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0050","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1152\/jappl.2000.89.1.38","article-title":"Sprint training normalizes Ca(2+) transients and SR function in postinfarction rat myocytes","volume":"89","author":"Zhang","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0055","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.jprot.2010.06.009","article-title":"Proteomic analysis reveals late exercise effects on cardiac remodeling following myocardial infarction","volume":"73","author":"Bansal","year":"2010","journal-title":"J. Proteome"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0060","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.ijcard.2013.10.044","article-title":"Delayed rather than early exercise training attenuates ventricular remodeling after myocardial infarction","volume":"170","author":"Batista","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0065","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0008-6363(01)00565-X","article-title":"Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction","volume":"54","author":"Wisloff","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0070","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yjmcc.2007.10.004","article-title":"Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats","volume":"44","author":"Xu","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0075","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/cvr\/cvn229","article-title":"Late exercise training improves non-uniformity of transmural myocardial function in rats with ischaemic heart failure","volume":"81","author":"Mou","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0080","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000369683","article-title":"Influence of N-acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats","volume":"35","author":"Martinez","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0085","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000363003","article-title":"Heart failure-induced diaphragm myopathy","volume":"34","author":"Lima","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0090","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2613.2009.00683.x","article-title":"Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure","volume":"91","author":"Lima","year":"2010","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0095","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0271-5317(02)00454-2","article-title":"Food restriction-induced myocardial dysfunction demonstrated by the combination of in vivo and in vitro studies","volume":"22","author":"Okoshi","year":"2002","journal-title":"Nutr. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0100","first-page":"BR367","article-title":"Diet-induced obesity causes metabolic, endocrine and cardiac alterations in spontaneously hypertensive rats","volume":"16","author":"Oliveira Junior","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0105","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ijcard.2016.04.101","article-title":"Myocardial myostatin in spontaneously hypertensive rats with heart failure","volume":"215","author":"Damatto","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0110","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1590\/S0100-879X1997000900013","article-title":"Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats","volume":"30","author":"Okoshi","year":"1997","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0115","first-page":"374","article-title":"Chronic heart failure-induced skeletal muscle atrophy, necrosis, and myogenic regulatory factors changes","volume":"16","author":"Martinez","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0120","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1475-2840-12-152","article-title":"Diabetes mellitus activated fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats","volume":"12","author":"Rosa","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0125","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1159\/000354526","article-title":"Aldosterone blockade reduces mortality without changing cardiac remodeling in spontaneously hypertensive rats","volume":"32","author":"Cezar","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0130","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1152\/ajpheart.00174.2006","article-title":"Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes","volume":"294","author":"Yan","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0135","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ijcard.2012.03.063","article-title":"Heart failure-induced skeletal myopathy in spontaneously hypertensive rats","volume":"167","author":"Damatto","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086447","article-title":"AT1 receptor blockade attenuates insulin resistance and myocardial remodeling in rats with diet-induced obesity","volume":"9","author":"Oliveira-Junior","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000374053","article-title":"Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats","volume":"36","author":"Pagan","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0150","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1071-9164(99)90006-4","article-title":"Temporal dissociation of left ventricular function and remodeling following experimental myocardial infarction in rats","volume":"5","author":"Solomon","year":"1999","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0155","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","article-title":"Myocardial infarct size and ventricular function in rats","volume":"44","author":"Pfeffer","year":"1979","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0160","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/cvr\/cvn285","article-title":"Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat","volume":"81","author":"Mackiewicz","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0165","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1006\/jmcc.1999.1000","article-title":"Captopril treatment improves the sarcoplasmic reticular Ca(2+) transport in heart failure due to myocardial infarction","volume":"31","author":"Shao","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0170","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1006\/jmcc.2000.1270","article-title":"Phospholamban and cardiac contractile function","volume":"32","author":"Brittsan","year":"2000","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0175","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/hh1701.095522","article-title":"Transgenic expression of sarcoplasmic reticulum Ca(2+) ATPase modifies the transition from hypertrophy to early heart failure","volume":"89","author":"Ito","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0180","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0271-5317(03)00071-X","article-title":"Myocardial dysfunction induced by food restriction is related to calcium cycling and beta-adrenergic system changes","volume":"23","author":"Gut","year":"2003","journal-title":"Nutr. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0185","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10741-013-9373-z","article-title":"Calcium handling proteins: structure, function, and modulation by exercise","volume":"19","author":"Locatelli","year":"2014","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0190","series-title":"Braunwald's Heart Disease. A Textbook of Cardiovascular Medicine","first-page":"459","article-title":"Mechanisms of cardiac contraction and relaxation","author":"Opie","year":"2012"},{"key":"10.1016\/j.ijcard.2016.07.072_bb0195","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1161\/01.RES.0000060027.40275.A6","article-title":"Is depressed myocyte contractility centrally involved in heart failure?","volume":"92","author":"Houser","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0200","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1113\/jphysiol.2004.073940","article-title":"Modulation of cytosolic and intra-sarcoplasmic reticulum calcium waves by calsequestrin in rat cardiac myocytes","volume":"561","author":"Kubalova","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-013-1560-7","article-title":"Altered calsequestrin glycan processing is common to diverse models of canine heart failure","volume":"377","author":"Jacob","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.33549\/physiolres.931948","article-title":"Defective Ca(2+) handling proteins regulation during heart failure","volume":"60","author":"Hu","year":"2011","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0215","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1172\/JCI1362","article-title":"Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin","volume":"101","author":"Jones","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0220","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.RES.0000262655.16373.37","article-title":"Early exercise training normalizes myofilament function and attenuates left ventricular pump dysfunction in mice with a large myocardial infarction","volume":"100","author":"de Waard","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0225","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1152\/japplphysiol.00405.2001","article-title":"Exercise training normalizes altered calcium-handling proteins during development of heart failure","volume":"92","author":"Lu","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/japplphysiol.00493.2007","article-title":"Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice","volume":"104","author":"Medeiros","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0235","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/jmcc.1994.1008","article-title":"Alterations in gene expression in the rat heart after chronic pathological and physiological loads","volume":"26","author":"Buttrick","year":"1994","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0240","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.jacc.2015.02.063","article-title":"Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States","volume":"65","author":"Aragam","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001800.pub2","article-title":"Exercise-based cardiac rehabilitation for coronary heart disease","volume":"7","author":"Heran","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ijcard.2016.07.072_bb0250","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijcard.2013.11.001","article-title":"A statement on ethical standards in publishing scientific articles in the International Journal of Cardiology family of journals","volume":"170","author":"Shewan","year":"2014","journal-title":"Int. J. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731631436X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731631436X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T13:31:46Z","timestamp":1600867906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016752731631436X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":50,"alternative-id":["S016752731631436X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.072","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of late exercise on cardiac remodeling and myocardial calcium handling proteins in rats with moderate and large size myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}