{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:27:30Z","timestamp":1774438050788,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010547","name":"Assiut University Faculty of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010547","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ijcard.2016.07.178","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:36:54Z","timestamp":1469925414000},"page":"866-873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Cardioprotective effect of atorvastatin alone or in combination with remote ischemic preconditioning on the biochemical changes induced by ischemic\/reperfusion injury in a mutual prospective study with a clinical and experimental animal arm"],"prefix":"10.1016","volume":"222","author":[{"given":"Ehab S.","family":"EL Desoky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-0805","authenticated-orcid":false,"given":"Ayman K.M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safaa Y.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabah A.","family":"Fadil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira F.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijcard.2016.07.178_bb0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia\u2013reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2016.07.178_bb0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"10","key":"10.1016\/j.ijcard.2016.07.178_bb0015","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/j.1552-4604.1998.tb04383.x","article-title":"Sodium ion\/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury","volume":"38","author":"Levitsky","year":"1998","journal-title":"J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.ijcard.2016.07.178_bb0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: from basic science to clinical bedside","volume":"16","author":"Frank","year":"2012","journal-title":"Semin. Cardiothorac. Vasc. Anesth."},{"issue":"9","key":"10.1016\/j.ijcard.2016.07.178_bb0025","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cjca.2012.11.022","article-title":"Remote ischemic preconditioning reduces myocardial injury in patients undergoing coronary stent implantation","volume":"29","author":"Luo","year":"2013","journal-title":"Can. J. Cardiol."},{"issue":"5","key":"10.1016\/j.ijcard.2016.07.178_bb0030","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0021-9150(03)00238-7","article-title":"Ischemic preconditioning: nearly two decades of research. A comprehensive review","volume":"172","author":"Eisen","year":"2004","journal-title":"Atherosclerosis"},{"issue":"3\u20134","key":"10.1016\/j.ijcard.2016.07.178_bb0040","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/1074248411411711","article-title":"Remote ischemic conditioning: a clinical trial's update","volume":"16","author":"Candilio","year":"2011","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"29","key":"10.1016\/j.ijcard.2016.07.178_bb0045","first-page":"1846","article-title":"Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"36","author":"Hausenloy","year":"2015","journal-title":"Eur. Heart J."},{"issue":"8201","key":"10.1016\/j.ijcard.2016.07.178_bb0050","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0140-6736(80)92101-7","article-title":"Warm-up phenomenon in angina pectoris","volume":"2","author":"Jaffe","year":"1980","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ijcard.2016.07.178_bb0055","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/01.CIR.87.3.893","article-title":"Regional ischemic \u2018preconditioning\u2019 protects remote virgin myocardium from subsequent sustained coronary occlusion","volume":"87","author":"Przyklenk","year":"1993","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.ijcard.2016.07.178_bb0060","first-page":"1162","article-title":"Atorvastatin inhibits platelet aggregation and activation following carotid balloon injury in cholesterol-fed rabbits","volume":"34","author":"Tong","year":"2014","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0065","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00380-012-0259-0","article-title":"Low-dose atorvastatin, losartan, and particularly their combination, provide cardiovascular protection in isolated rat heart and aorta","volume":"28","author":"Lunder","year":"2013","journal-title":"Heart Vessel."},{"issue":"4","key":"10.1016\/j.ijcard.2016.07.178_bb0070","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol. Rev."},{"issue":"23","key":"10.1016\/j.ijcard.2016.07.178_bb0075","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1161\/01.CIR.0000043806.51912.9B","article-title":"Transient limb ischemia induces remote ischemic preconditioning in vivo","volume":"106","author":"Kharbanda","year":"2002","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ijcard.2016.07.178_bb0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ehj.2015.08.001","article-title":"Cardio- and reno-protective effect of remote ischemic preconditioning in patients undergoing percutaneous coronary intervention. A prospective, non-randomized controlled trial","volume":"67","author":"Hassan","year":"2015","journal-title":"Egypt. Heart J."},{"issue":"48","key":"10.1016\/j.ijcard.2016.07.178_bb0085","doi-asserted-by":"crossref","DOI":"10.3791\/2464","article-title":"Acute myocardial infarction in rats","author":"Wu","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"12","key":"10.1016\/j.ijcard.2016.07.178_bb0090","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1248\/bpb.28.2319","article-title":"Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia\u2013reperfusion induced myocardial infarction in rats","volume":"28","author":"Rao","year":"2005","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0095","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1113\/expphysiol.2012.066217","article-title":"Role of the parasympathetic nervous system in cardioprotection by remote hindlimb ischaemic preconditioning","volume":"98","author":"Donato","year":"2013","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.178_bb0100","doi-asserted-by":"crossref","first-page":"134862","DOI":"10.1155\/2014\/134862","article-title":"Cardioprotection against ischemia\/reperfusion by licochalcone B in isolated rat hearts","volume":"2014","author":"Han","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0105","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10753-014-9959-1","article-title":"Protective effects of embelin on myocardial ischemia\u2013reperfusion injury following cardiac arrest in a rabbit model","volume":"38","author":"Zhao","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.ijcard.2016.07.178_bb0110","doi-asserted-by":"crossref","first-page":"815094","DOI":"10.1155\/2013\/815094","article-title":"Antiapoptotic effect of simvastatin ameliorates myocardial ischemia\/reperfusion injury","volume":"2013","author":"Hadi","year":"2013","journal-title":"ISRN Pharmacol."},{"issue":"21","key":"10.1016\/j.ijcard.2016.07.178_bb0115","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.3760\/cma.j.issn.0366-6999.20141199","article-title":"Effect of short-term high-dose atorvastatin on systemic inflammatory response and myocardial ischemic injury in patients with unstable angina pectoris undergoing percutaneous coronary intervention","volume":"127","author":"Sun","year":"2014","journal-title":"Chin. Med. J."},{"issue":"4","key":"10.1016\/j.ijcard.2016.07.178_bb0120","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cardiores.2003.11.038","article-title":"Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis","volume":"61","author":"Monaco","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.ijcard.2016.07.178_bb0125","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1582-4934.2010.01036.x","article-title":"Statins potently reduce the cytokine-mediated IL-6 release in SMC\/MNC cocultures","volume":"15","author":"Loppnow","year":"2011","journal-title":"J. Cell. Mol. Med."},{"issue":"11","key":"10.1016\/j.ijcard.2016.07.178_bb0130","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2174\/138161212799504803","article-title":"Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials","volume":"18","author":"Antonopoulos","year":"2012","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0135","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bbrc.2009.03.019","article-title":"Effect of atorvastatin on expression of IL-10 and TNF-alpha mRNA in myocardial ischemia\u2013reperfusion injury in rats","volume":"382","author":"Sun","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijcard.2016.07.178_bb0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12944-015-0041-2","article-title":"Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats","volume":"14","author":"Zheng","year":"2015","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ijcard.2016.07.178_bb0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1465-9921-12-137","article-title":"Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells","volume":"12","author":"Ali","year":"2011","journal-title":"Respir. Res."},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0150","first-page":"63","article-title":"Simvastatin suppresses the proangiogenic microenvironment of human hepatic stellate cells via the Kruppel-like factor 2 pathway","volume":"107","author":"Miao","year":"2015","journal-title":"Rev. Esp. Enferm. Dig."},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0155","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3892\/etm.2013.1432","article-title":"Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST-segment elevation myocardial infarction","volume":"7","author":"Yong","year":"2014","journal-title":"Exp. Ther. Med."},{"issue":"12","key":"10.1016\/j.ijcard.2016.07.178_bb0160","first-page":"4915","article-title":"Atorvastatin ameliorates myocardial ischemia\/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Wu","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"16","key":"10.1016\/j.ijcard.2016.07.178_bb0165","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","article-title":"Third universal definition of myocardial infarction","volume":"60","author":"Thygesen","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2016.07.178_bb0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physiolgenomics.00046.2004","article-title":"The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans","volume":"19","author":"Konstantinov","year":"2004","journal-title":"Physiol. Genomics"},{"issue":"2","key":"10.1016\/j.ijcard.2016.07.178_bb0175","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1681\/ASN.2013070708","article-title":"Remote ischemic preconditioning and renoprotection: from myth to a novel therapeutic option?","volume":"25","author":"Gassanov","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ijcard.2016.07.178_bb0180","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.aca.2013.09.029","article-title":"Simultaneous, real-time measurement of nitric oxide and oxygen dynamics during cardiac ischemia\u2013reperfusion of the rat utilizing sol\u2013gel-derived electrochemical microsensors","volume":"802","author":"Kang","year":"2013","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.ijcard.2016.07.178_bb0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00246-009-9536-9","article-title":"Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants","volume":"31","author":"Zhou","year":"2010","journal-title":"Pediatr. Cardiol."},{"issue":"12","key":"10.1016\/j.ijcard.2016.07.178_bb0190","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.4244\/EIJV9I12A244","article-title":"Cardiac remote ischaemic preconditioning reduces periprocedural myocardial infarction for patients undergoing percutaneous coronary interventions: a meta-analysis of randomised clinical trials","volume":"9","author":"D'Ascenzo","year":"2014","journal-title":"EuroIntervention"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316315716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316315716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T09:57:42Z","timestamp":1749031062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316315716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":38,"alternative-id":["S0167527316315716"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.178","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotective effect of atorvastatin alone or in combination with remote ischemic preconditioning on the biochemical changes induced by ischemic\/reperfusion injury in a mutual prospective study with a clinical and experimental animal arm","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}