{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:20:52Z","timestamp":1777598452879,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Science and Technology in Heilongjiang Province","award":["GC05C40304"],"award-info":[{"award-number":["GC05C40304"]}]},{"DOI":"10.13039\/501100010845","name":"Harbin Science and Technology Bureau","doi-asserted-by":"crossref","award":["2005 AFXXJ 047"],"award-info":[{"award-number":["2005 AFXXJ 047"]}],"id":[{"id":"10.13039\/501100010845","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Education in Heilongjiang Province","award":["10551213"],"award-info":[{"award-number":["10551213"]}]},{"name":"Department of Health in Heilongjiang Province","award":["2005-200"],"award-info":[{"award-number":["2005-200"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ijcard.2016.07.188","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T16:17:28Z","timestamp":1469981848000},"page":"178-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effects of carvedilol on ventricular remodeling and the expression of \u03b2 3 -adrenergic receptor in a diabetic rat model subjected myocardial infarction"],"prefix":"10.1016","volume":"222","author":[{"given":"Ruiying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.07.188_bb0005","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s001250051556","article-title":"A new look at the heart in diabetes mellitus: from ailing to failing","volume":"43","author":"Standl","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2337\/diab.23.2.105","article-title":"Morbidity and mortality in diabetics in the Framingham population: sixteen year follow-up study","volume":"23","author":"Garcia","year":"1974","journal-title":"Diabetes"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0735-1097(95)00425-4","article-title":"Analysis of \u00df-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: progressive reduction of \u00df1-adrenergic receptor mRNA in heart failure","volume":"27","author":"Engelhardt","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0020","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI119770","article-title":"Changes in gene expression in the intact human heart: downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium","volume":"100","author":"Lowes","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/jmcc.1994.1017","article-title":"Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure","volume":"26","author":"B\u00f6hm","year":"1994","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0030","doi-asserted-by":"crossref","first-page":"H2425","DOI":"10.1152\/ajpheart.01045.2003","article-title":"Endogenous \u03b23-adrenoreceptor activation contributes to the left ventricular and cardiomyocyte dysfunction in heart failure","volume":"286","author":"Morimoto","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0035","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI2191","article-title":"The negative inotropic effect of \u00df3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle","volume":"102","author":"Gauthier","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.ijcard.2016.07.188_bb0040","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.bbamcr.2013.01.019","article-title":"Biphasic Erk1\/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell proliferation","volume":"1833","author":"Hadi","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.2002.025973","article-title":"Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice","volume":"5461","author":"Massion","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0050","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.CIR.103.12.1649","article-title":"Upregulation of \u03b23-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium","volume":"103","author":"Moniotte","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0055","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2337\/diabetes.50.2.455","article-title":"The effect of diabetes on expression of \u03b21-,\u03b22- and \u03b23-adrenoceptors in rats hearts","volume":"50","author":"Dincer","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0060","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1161\/hh1901.098042","article-title":"Upregulation of functional \u03b23-adrenergic receptor in the failing canine myocardium","volume":"89","author":"Cheng","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0065","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/00005344-200010000-00008","article-title":"Binding properties of \u03b2-blockers at recombinant \u03b21-, \u03b22-, and \u03b23-adrenoceptors","volume":"36","author":"Schnabel","year":"2000","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0070","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10557-007-6016-4","article-title":"Effect of beta-blockers on beta3-adrenoceptor expression in chronic heart failure","volume":"21","author":"Zhao","year":"2007","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0075","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.ijcard.2016.07.188_bb0080","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1111\/j.1523-1755.2005.00727.x","article-title":"Kidney involvement in a nongenetic rat model of type 2 diabetes.2","volume":"68","author":"Danda","year":"2005","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.ijcard.2016.07.188_bb0085","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000430258","article-title":"Antidiabetic effect of salvianolic acid A on diabetic animal models via AMPK activation and mitochondrial regulation","volume":"36","author":"Qiang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.ijcard.2016.07.188_bb0090","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1536\/jhj.44.979","article-title":"Comparison of metoprolol with low, middle and high doses of carvedilol in prevention of postinfarction left ventricular remodeling in rats","volume":"44","author":"Yang","year":"2003","journal-title":"Jpn. Heart J."},{"issue":"5","key":"10.1016\/j.ijcard.2016.07.188_bb0095","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00005344-199805000-00002","article-title":"Divergent effects of angiotensin-converting enzyme inhibition and angiotensin II-receptor antagonism on myocardial cellular proliferation and collagen deposition after myocardial infarction in rats","volume":"31","author":"Taylor","year":"1998","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/eurheartj\/ehi049","article-title":"Acute hyperglycaemia: a \u2018new\u2019 risk factor during myocardial infarction","volume":"26","author":"Ceriello","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0105","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0735-1097(03)00509-6","article-title":"Streptozotocin-induced hyperglycemia exacerbates left ventricular remodeling and failure after experimental myocardial infarction","volume":"42","author":"Shiomi","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2016.07.188_bb0110","first-page":"70","article-title":"Are there gender differences in left ventricular remodeling after myocardial infarction in rats?","volume":"30","author":"Antonio","year":"2015","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0115","doi-asserted-by":"crossref","first-page":"H1134","DOI":"10.1152\/ajpheart.2000.278.4.H1134","article-title":"Heterogeneous cardiac sympathetic innervation in heart failure after myocardial infarction of rats","volume":"278","author":"Igawa","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0120","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0002-8703(00)90036-X","article-title":"Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol","volume":"139","author":"Capomolla","year":"2000","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0125","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0735-1097(00)00671-9","article-title":"Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction","volume":"36","author":"Wei","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0130","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2165\/00003495-199345020-00006","article-title":"Carvedilol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy","volume":"45","author":"McTavish","year":"1993","journal-title":"Drugs"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0140","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.RES.0000102042.83024.CA","article-title":"What is the role of \u03b2-adrenergic signaling in heart failure?","volume":"93","author":"Lohse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0145","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/6165","article-title":"Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice","volume":"17","author":"Redfern","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0150","doi-asserted-by":"crossref","first-page":"H1653","DOI":"10.1152\/ajpheart.2001.280.4.H1653","article-title":"Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy","volume":"280","author":"Baker","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2016.07.188_bb0155","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/CIRCULATIONAHA.106.682773","article-title":"Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy","volume":"116","author":"Ruan","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(03)13800-7","article-title":"Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial","volume":"362","author":"Poole-Wilson","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0165","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/01.CIR.0000108928.25690.94","article-title":"Effects of carvedilol on left ventricular remodeling after acute myocardial infarction: the CAPRICORN echo substudy","volume":"109","author":"Doughty","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.07.188_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2010.07.030","article-title":"Ethics in the authorship and publishing of scientific articles","volume":"144","author":"Shewan","year":"2010","journal-title":"Int. J. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316315820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316315820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T02:26:34Z","timestamp":1589682394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316315820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":33,"alternative-id":["S0167527316315820"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.188","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of carvedilol on ventricular remodeling and the expression of \u03b23-adrenergic receptor in a diabetic rat model subjected myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.07.188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}