{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:53:53Z","timestamp":1765886033450},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Italian College of General Practitioners and Primary Care"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ijcard.2016.08.269","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T17:28:42Z","timestamp":1471714122000},"page":"701-705","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["What is the actual epidemiology of familial hypercholesterolemia in Italy? Evidence from a National Primary Care Database"],"prefix":"10.1016","volume":"223","author":[{"given":"Valeria","family":"Guglielmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Bellia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Pecchioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Medea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Parretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Lauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Sbraccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Federici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iacopo","family":"Cricelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Cricelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lapi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.08.269_bb0005","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ncpcardio0836","article-title":"Mechanisms of disease: genetic causes of familial hypercholesterolemia","volume":"4","author":"Soutar","year":"2007","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/MOL.0b013e32830636e5","article-title":"What is the clinical utility of DNA testing in patients with familial hypercholesterolaemia?","volume":"19","author":"Humphries","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0015","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2796.1998.00352.x","article-title":"Effects of atorvastatin on serum lipids of patients with familial hypercholesterolaemia","volume":"244","author":"Hoogerbrugge","year":"1998","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0020","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/eht273","article-title":"Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society","volume":"34","author":"Nordestgaard","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0025","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1093\/eurheartj\/ehu274","article-title":"Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society","volume":"35","author":"Cuchel","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0030","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.amjcard.2008.07.035","article-title":"Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia","volume":"102","author":"Kolansky","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0035","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.jacl.2011.03.452","article-title":"Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia","volume":"5","author":"Hopkins","year":"2011","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(02)00330-1","article-title":"A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia","volume":"168","author":"Marks","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ijcard.2013.11.025","article-title":"Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation","volume":"171","author":"Watts","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0050","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.atherosclerosis.2015.09.021","article-title":"Familial hypercholesterolaemia: a global call to arms","volume":"243","author":"Vallejo-Vaz","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0055","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-9149(93)90155-6","article-title":"Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics","volume":"72","author":"Williams","year":"1993","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0060","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/MOL.0b013e3283556c33","article-title":"Identification of people with heterozygous familial hypercholesterolemia","volume":"23","author":"Haase","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0140-6736(00)03587-X","article-title":"Review of first 5years of screening for familial hypercholesterolaemia in the Netherlands","volume":"357","author":"Umans-Eckenhausen","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0070","unstructured":"VIII Report Health Search. Anno 2013\/2014., In, (Firenze 2014)."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bone.2011.09.048","article-title":"Assessing 5-year incidence rates and determinants of osteoporotic fractures in primary care","volume":"50","author":"Lapi","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0080","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1183\/09031936.00128713","article-title":"Burden of community-acquired pneumonia in Italian general practice","volume":"42","author":"Sterrantino","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0085","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/clinchem\/31.10.1762a","article-title":"Estimation of low-density lipoprotein by the Friedewald formula and by electrophoresis compared","volume":"31","author":"Niedbala","year":"1985","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0095","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jpeds.2013.10.027","article-title":"Implementation of lipid screening guidelines in children by primary pediatric providers","volume":"164","author":"Dixon","year":"2014","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0100","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1093\/eurheartj\/ehv157","article-title":"Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment","volume":"36","author":"Wiegman","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0105","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1403494811414241","article-title":"The paradox of public health genomics: definition and diagnosis of familial hypercholesterolaemia in three European countries","volume":"39","author":"Aarden","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0110","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/bmj.321.7254.148","article-title":"Extent of underdiagnosis of familial hypercholesterolaemia in routine practice: prospective registry study","volume":"321","author":"Neil","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0115","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/CIRCULATIONAHA.114.012477","article-title":"Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease","volume":"131","author":"Navar-Boggan","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.amjcard.2004.03.023","article-title":"Framingham risk score and prediction of lifetime risk for coronary heart disease","volume":"94","author":"Lloyd-Jones","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.atherosclerosis.2009.09.014","article-title":"Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands","volume":"209","author":"Pijlman","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2016.08.269_bb0130","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/eurheartj\/ehv563","article-title":"The impact of proprotein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia: a network meta-analysis","volume":"37","author":"Lipinski","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0135","doi-asserted-by":"crossref","first-page":"139","DOI":"10.18553\/jmcp.2013.19.2.139","article-title":"Management of familial hypercholesterolemia: a review of the recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia","volume":"19","author":"Robinson","year":"2013","journal-title":"J. Manag. Care Pharm."},{"key":"10.1016\/j.ijcard.2016.08.269_bb0140","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCGENETICS.115.001256","article-title":"so far, PCSK9 inhibitors work for all heterozygous FH patients","volume":"8","author":"McNutt","year":"2015","journal-title":"Circ. Cardiovasc. Genet."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316319763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316319763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T16:10:25Z","timestamp":1657123825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316319763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":27,"alternative-id":["S0167527316319763"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.08.269","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What is the actual epidemiology of familial hypercholesterolemia in Italy? Evidence from a National Primary Care Database","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.08.269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}