{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:32:51Z","timestamp":1791343971077,"version":"4.3.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.ijcard.2016.10.061","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T22:50:15Z","timestamp":1477522215000},"page":"757-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Impact of exercise training associated to pyridostigmine treatment on autonomic function and inflammatory profile after myocardial infarction in rats"],"prefix":"10.1016","volume":"227","author":[{"given":"Daniele J.","family":"Feriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel I.H.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle M.","family":"Carrozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Mostarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo M.M.","family":"Dourado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda M.","family":"Consolim-Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia","family":"De Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cl\u00e1udia","family":"Irigoyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2016.10.061_bb0005","first-page":"e29","article-title":"American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics\u20132015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.amjcard.2008.03.081","article-title":"Patterns of structural and functional remodeling of the left ventricle in chronic heart failure","volume":"102","author":"Gaasch","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0015","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.CIR.98.2.149","article-title":"Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodeling","volume":"98","author":"Ono","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0025","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.jacc.2007.08.043","article-title":"Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function","volume":"50","author":"De Ferrari","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1152\/japplphysiol.01368.2007","article-title":"Exercise training in heart failure: reduction in angiotensin II, sympathetic nerve activity, and baroreflex control","volume":"104","author":"Negr\u00e3o","year":"2008","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0035","doi-asserted-by":"crossref","first-page":"715","DOI":"10.33549\/physiolres.932110","article-title":"Sudden cardiac death thirty years ago and at present. The role of autonomic disturbances in acute myocardial infarction revisited","volume":"60","author":"Pokorn\u00fd","year":"2011","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0040","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1475-097X.2009.00887.x","article-title":"Cardiac sympathetic activity is associated with inflammation and neurohumoral activation in patients with idiopathic dilated cardiomyopathy","volume":"29","author":"Turpeinen","year":"2009","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10741-010-9216-0","article-title":"Vagus nerve stimulation: from pre-clinical to clinical application: challenges and future directions","volume":"16","author":"De Ferrari","year":"2011","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10741-010-9195-1","article-title":"Pharmacologic modulation of parasympathetic activity in heart failure","volume":"16","author":"Desai","year":"2011","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0055","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0735-1097(98)90065-1","article-title":"Modulation of an idioventricular rhythm by vagal tone","volume":"11","author":"Waxman","year":"1988","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0060","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/01.CIR.0000105721.71640.DA","article-title":"Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats","volume":"109","author":"Li","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0065","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCHEARTFAILURE.109.873968","article-title":"Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model","volume":"2","author":"Zhang","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0070","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/1440-1681.12121","article-title":"Cholinergic stimulation with pyridostigmine improves autonomic function in infarcted rats","volume":"40","author":"De La Fuente","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0075","doi-asserted-by":"crossref","first-page":"R908","DOI":"10.1152\/ajpregu.00102.2013","article-title":"Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure","volume":"305","author":"Lataro","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0080","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1093\/eurheartj\/ehr299","article-title":"Baroreflex deficiency hampers angiogenesis after myocardial infarction via acetylcholine-\u03b17-nicotinic ACh receptor in rats","volume":"34","author":"Yu","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104476","article-title":"Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in mice","volume":"9","author":"Durand","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0090","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/jcp.22424","article-title":"Acetylcholine inhibits hypoxia-induced tumor necrosis factor-\u03b1 production via regulation of MAPKs phosphorylation in cardiomyocytes","volume":"226","author":"Li","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0095","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway","volume":"117","author":"Tracey","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0100","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1152\/ajpregu.00328.2015","article-title":"Increase in cholinergic modulation with pyridostigmine induces anti-inflammatory cell recruitment soon after acute myocardial infarction in rats","volume":"310","author":"Rocha","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0105","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/eurheartj\/ehq244","article-title":"Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality","volume":"32","author":"Jorge","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0110","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/01.CIR.0000027565.12764.E1","article-title":"Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction","volume":"106","author":"La Rovere","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0115","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/HYPERTENSIONAHA.111.176644","article-title":"Effects of long-term exercise training on autonomic control in myocardial infarction patients","volume":"58","author":"Martinez","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0120","article-title":"Role of training and detraining on inflammatory and metabolic profile in infarcted rats: influences of cardiovascular autonomic nervous system","volume":"207131","author":"Rodrigues","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0125","doi-asserted-by":"crossref","first-page":"H1115","DOI":"10.1152\/ajpheart.00349.2015","article-title":"Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR","volume":"309","author":"Masson","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0130","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1590\/S0100-879X2008005000007","article-title":"Determination of myocardial infarction size in rats by echocardiography and tetrazolium staining: correlation, agreements, and simplifications","volume":"41","author":"dos Santos","year":"2008","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1475-2840-6-38","article-title":"Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats","volume":"6","author":"Rodrigues","year":"2007","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0140","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1152\/japplphysiol.00883.2014","article-title":"Impact of combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats","volume":"119","author":"Sanches","year":"2015","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/1043-6618(91)90120-M","article-title":"Spectral analysis of cardiovascular variabilities in the assessment of sympathetic cardiac regulation in heart failure","volume":"24","author":"Malliani","year":"1991","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric assay determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0155","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1113\/jphysiol.2012.243121","article-title":"Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats","volume":"591","author":"Ferguson","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0160","doi-asserted-by":"crossref","first-page":"H690","DOI":"10.1152\/ajpheart.00901.2013","article-title":"Skeletal muscle microvascular oxygenation dynamics in heart failure: exercise training and nitric oxide-mediated function","volume":"306","author":"Hirai","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0165","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00421-009-1230-3","article-title":"Assessment of the effects of physical training in patients with chronic heart failure: the utility of effort-independent exercise variables","volume":"108","author":"Kemps","year":"2010","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0170","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/j.ijcard.2012.05.124","article-title":"Speeding of pulmonary VO2 on-kinetics by light-to-moderate-intensity aerobic exercise training in chronic heart failure: clinical and pathophysiological correlates","volume":"167","author":"Mezzani","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0175","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/HJR.0b013e32808621a3","article-title":"The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure","volume":"14","author":"Roditis","year":"2007","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0180","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/01.hjr.0000173106.68485.b7","article-title":"Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure","volume":"12","author":"Hambrecht","year":"2005","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0185","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1152\/japplphysiol.00346.2011","article-title":"Aerobic exercise training upregulates skeletal muscle calpain and ubiquitin-proteasome systems in healthy mice","volume":"112","author":"Cunha","year":"2012","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0190","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1152\/japplphysiol.00760.2012","article-title":"High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats","volume":"114","author":"Moreira","year":"2013","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0195","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(97)11144-8","article-title":"Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators","volume":"14","author":"La Rovere","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0200","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.autneu.2006.10.009","article-title":"Influence of cardiopulmonary reflex on the sympathetic activity during myocardial infarction","volume":"133","author":"Lacerda","year":"2007","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0205","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.autneu.2014.10.015","article-title":"Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure","volume":"188","author":"Haack","year":"2015","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0210","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.autneu.2012.11.007","article-title":"The treatment with pyridostigmine improves the cardiocirculatory function in rats with chronic heart failure","volume":"173","author":"Sabino","year":"2013","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0215","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0220","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1152\/ajpendo.00074.2003","article-title":"IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans","volume":"285","author":"Steensberg","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0225","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0735-1097(01)01795-8","article-title":"Physical training modulates proinflammatory cytokines and the soluble Fas\/soluble Fas ligand system in patients with chronic heart failure","volume":"39","author":"Adamopoulos","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0230","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cyto.2009.10.007","article-title":"Exercise training changes IL-10\/TNF-\u03b1 ratio in the skeletal muscle of post-MI rats","volume":"49","author":"Batista","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.ijcard.2016.10.061_bb0235","doi-asserted-by":"crossref","first-page":"H345","DOI":"10.1152\/ajpheart.00683.2014","article-title":"Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice","volume":"309","author":"Puhl","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2016.10.061_bb0240","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/ajh\/hpv017","article-title":"Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats","volume":"28","author":"Lataro","year":"2015","journal-title":"Am. J. Hypertens."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316331576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316331576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T23:33:44Z","timestamp":1601163224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316331576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":48,"alternative-id":["S0167527316331576"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.10.061","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of exercise training associated to pyridostigmine treatment on autonomic function and inflammatory profile after myocardial infarction in rats","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.10.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}