{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:39:14Z","timestamp":1787960354123,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.ijcard.2016.11.114","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T07:30:22Z","timestamp":1478676622000},"page":"906-911","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Usefulness of CHADS2 score for prognostic stratification of patients with coronary artery disease: A systematic review and meta-analysis of cohort studies"],"prefix":"10.1016","volume":"228","author":[{"given":"Xiaobo","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqing","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shencheng","family":"QU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.112.155911","article-title":"National Forum for Heart Disease and Stroke Prevention. Heart disease and stroke statistics\u20132013 update: a report from the American Heart Association","volume":"127","author":"Sidney","year":"2013","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.ijcard.2016.11.114_bb0010","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jacc.2012.03.074","article-title":"Cardiovascular disease in the developing world: prevalences, patterns, and the potential of early disease detection","volume":"60","author":"Celermajer","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7578","key":"10.1016\/j.ijcard.2016.11.114_bb0015","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/bmj.38985.646481.55","article-title":"Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE)","volume":"333","author":"Fox","year":"2006","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.ijcard.2016.11.114_bb0020","doi-asserted-by":"crossref","DOI":"10.1001\/jama.284.7.835","article-title":"The TIMI risk score for unstable angina\/non-ST elevation MI: a method for prognostication and therapeutic decision making","volume":"284","author":"Antman","year":"2000","journal-title":"JAMA"},{"issue":"22","key":"10.1016\/j.ijcard.2016.11.114_bb0025","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1161\/01.CIR.101.22.2557","article-title":"Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT investigators","volume":"101","author":"Boersma","year":"2000","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.ijcard.2016.11.114_bb0030","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1001\/jama.285.22.2864","article-title":"Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation","volume":"285","author":"Gage","year":"2001","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/europace\/eut190","article-title":"CHADS2 and CHA2DS2-VASc scores to predict morbidity and mortality in heart failure patients candidates to cardiac resynchronization therapy","volume":"16","author":"Paoletti Perini","year":"2014","journal-title":"Europace"},{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijcard.2008.11.122","article-title":"Survival after stroke\u2014the impact of CHADS2 score and atrial fibrillation","volume":"141","author":"Henriksson","year":"2010","journal-title":"Int. J. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcard.2016.11.114_bb0045","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ahj.2011.05.023","article-title":"The CHADS2 score predicts ischemic stroke in the absence of atrial fibrillation among patients with coronary heart disease: data from the heart and soul study","volume":"162","author":"Welles","year":"2011","journal-title":"Am. Heart J."},{"issue":"6","key":"10.1016\/j.ijcard.2016.11.114_bb0050","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1378\/chest.11-0435","article-title":"Role of the CHADS2 score in acute coronary syndromes: risk of subsequent death or stroke in patients with and without atrial fibrillation","volume":"141","author":"Po\u00e7i","year":"2012","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.ijcard.2016.11.114_bb0055","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1371\/journal.pone.0111167","article-title":"Use of CHADS\u2082 and CHA\u2082DS\u2082-VASc scores to predict subsequent myocardial infarction, stroke, and death in patients with acute coronary syndrome: data from Taiwan acute coronary syndrome full spectrum registry","volume":"9","author":"Chua","year":"2014","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.ijcard.2016.11.114_bb0060","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/heartjnl-2013-305303","article-title":"APPROACH investigators. Prediction of stroke or TIA in patients without atrial fibrillation using CHADS2 and CHA2DS2-VASc scores","volume":"100","author":"Mitchell","year":"2014","journal-title":"Heart"},{"issue":"5","key":"10.1016\/j.ijcard.2016.11.114_bb0065","first-page":"474","article-title":"Roles of the CHADS2 and CHA2DS2-VASc scores in post-myocardial infarction patients: risk of new occurrence of atrial fibrillation and ischemic stroke","volume":"21","author":"Lau","year":"2014","journal-title":"Cartogr. J."},{"issue":"8","key":"10.1016\/j.ijcard.2016.11.114_bb0070","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.11.004","article-title":"CHADS2 and CHA2DS2-VASc scores for prediction of immediate and late stroke after coronary artery bypass graft surgery","volume":"22","author":"Biancari","year":"2013","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"6","key":"10.1016\/j.ijcard.2016.11.114_bb0075","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1378\/chest.10-1408","article-title":"An evaluation of the CHADS 2 stroke risk score in patients with atrial fibrillation who undergo percutaneous coronary revascularization","volume":"139","author":"Ruiz-Nodar","year":"2011","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.ijcard.2016.11.114_bb0080","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.thromres.2014.01.007","article-title":"CHADS2, CHA2DS2-VASc and HAS-BLED as predictors of outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention","volume":"133","author":"Puurunen","year":"2014","journal-title":"Thromb. Res."},{"issue":"15","key":"10.1016\/j.ijcard.2016.11.114_bb0085","doi-asserted-by":"crossref","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2016.11.114_bb0090","author":"Wells"},{"issue":"3","key":"10.1016\/j.ijcard.2016.11.114_bb0095","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"issue":"12","key":"10.1016\/j.ijcard.2016.11.114_bb0100","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/sim.3602","article-title":"Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses","volume":"29","author":"Jackson","year":"2010","journal-title":"Stat. Med."},{"issue":"7414","key":"10.1016\/j.ijcard.2016.11.114_bb0105","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.ijcard.2016.11.114_bb0110","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/ije\/dyn204","article-title":"Commentary: heterogeneity in meta-analysis should be expected and appropriately quantified","volume":"37","author":"Higgins","year":"2008","journal-title":"Int. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.ijcard.2016.11.114_bb0115","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"issue":"7109","key":"10.1016\/j.ijcard.2016.11.114_bb0120","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.ijcard.2016.11.114_bb0125","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.recesp.2014.06.028","article-title":"The CHADS2 score to predict stroke risk in the absence of atrial fibrillation in hypertensive patients aged 65years or older","volume":"68","author":"Morillas","year":"2015","journal-title":"Rev. Esp. Cardiol. (Engl Ed)"},{"issue":"11","key":"10.1016\/j.ijcard.2016.11.114_bb0130","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1212\/WNL.0b013e318287281b","article-title":"CHADS2, CHA2DS2-VASc, and long-term stroke outcome in patients without atrialfibrillation","volume":"80","author":"Ntaios","year":"2013","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mayocp.2015.09.021","article-title":"CHADS2 scores as a predictor of ischemic stroke in patients with peripheral artery disease","volume":"91","author":"Yang","year":"2016","journal-title":"Mayo Clin. Proc."},{"issue":"6","key":"10.1016\/j.ijcard.2016.11.114_bb0140","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.10.014","article-title":"CHADS2- and CHA2DS2VASc scores and embolic risk in left ventricular hypertrabeculation\/noncompaction","volume":"22","author":"Stollberger","year":"2013","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"2","key":"10.1016\/j.ijcard.2016.11.114_bb0145","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.atherosclerosis.2014.08.026","article-title":"The CHADS2 and CHA2DS2-VASc scores predict adverse vascular function, ischemic stroke and cardiovascular death in high-risk patients without atrial fibrillation: role of incorporating PR prolongation","volume":"237","author":"Chan","year":"2014","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0150","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijcard.2012.09.148","article-title":"Comparative assessment of published atrial fibrillation. Stroke risk stratification schemes for predicting stroke, in a non-atrialfibrillation population: the Chin-Shan Community Cohort Study","volume":"168","author":"Lip","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/clc.22334","article-title":"The influence of type 2 diabetes on left atrial remodeling","volume":"38","author":"Tadic","year":"2015","journal-title":"Clin. Cardiol."},{"issue":"12","key":"10.1016\/j.ijcard.2016.11.114_bb0160","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/01.CIR.0000090688.49283.67","article-title":"Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans","volume":"108","author":"Sanders","year":"2003","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.ijcard.2016.11.114_bb0165","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.4065\/79.8.1008","article-title":"Left atrial volume in the prediction of first ischemic stroke in an elderly cohort without atrial fibrillation","volume":"79","author":"Barnes","year":"2004","journal-title":"Mayo Clin. Proc."},{"issue":"6","key":"10.1016\/j.ijcard.2016.11.114_bb0170","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0735-1097(98)00093-X","article-title":"Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease","volume":"31","author":"Mehta","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2007.09.026","article-title":"Structural and functional remodeling of the left atriumclinical and therapeutic implications for atrial fibrillation","volume":"51","author":"Casaclang-Verzosa","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2016.11.114_bb0180","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.amjcard.2015.05.010","article-title":"Meta-analysis of CHADS2 score in predicting atrial fibrillation","volume":"116","author":"Yang","year":"2015","journal-title":"Am. J. Cardiol."},{"issue":"21","key":"10.1016\/j.ijcard.2016.11.114_bb0185","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.jacc.2010.02.026","article-title":"Intravascular ultrasound-derived measures of coronary atherosclerotic plaque burden and clinical outcome","volume":"55","author":"Nicholls","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.ijcard.2016.11.114_bb0190","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.amjcard.2010.01.359","article-title":"Comparison of rates of progression of coronary atherosclerosis in patients with diabetes mellitus versus those with the metabolic syndrome","volume":"105","author":"Bayturan","year":"2010","journal-title":"Am. J. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2016.11.114_bb0195","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1053\/euhj.1997.0822","article-title":"Long-term prognosis after acute myocardial infarction in patients with a history of arterial hypertension. TRACE study group","volume":"19","author":"Gustafsson","year":"1998","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.ijcard.2016.11.114_bb0200","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1524-6175.2006.05384.x","article-title":"Association of a history of systemic hypertension with mortality, thrombotic, and bleeding complications following non-ST-segment elevation acute coronary syndrome","volume":"8","author":"Dumaine","year":"2006","journal-title":"J. Clin. Hypertens."},{"issue":"9","key":"10.1016\/j.ijcard.2016.11.114_bb0205","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.CIR.102.9.1014","article-title":"Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry","volume":"102","author":"Malmberg","year":"2000","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcard.2016.11.114_bb0210","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ahj.2004.06.003","article-title":"(2005) impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE)","volume":"149","author":"Avezum","year":"2005","journal-title":"Am. Heart J."},{"issue":"3","key":"10.1016\/j.ijcard.2016.11.114_bb0215","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cct.2012.01.001","article-title":"TIMI, GRACE and alternative risk scores in acute coronary syndromes: a meta-analysis of 40 derivation studies on 216,552 patients and of 42 validation studies on 31,625 patients","volume":"33","author":"D'Ascenzo","year":"2012","journal-title":"Control. Clin. Trials"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316335732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316335732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T04:48:52Z","timestamp":1552970932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316335732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":43,"alternative-id":["S0167527316335732"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.11.114","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Usefulness of CHADS2 score for prognostic stratification of patients with coronary artery disease: A systematic review and meta-analysis of cohort studies","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2016.11.114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}