{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:37:34Z","timestamp":1768739854732,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006692","name":"University of Turin","doi-asserted-by":"publisher","award":["PAGP_RILO_16_01"],"award-info":[{"award-number":["PAGP_RILO_16_01"]}],"id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ijcard.2017.01.122","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T03:30:23Z","timestamp":1485833423000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Myocardial ischemia\/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress"],"prefix":"10.1016","volume":"233","author":[{"given":"Michela","family":"Morano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelina","family":"Angotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Tullio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Gambarotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Penna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-1383","authenticated-orcid":false,"given":"Pasquale","family":"Pagliaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Geuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2017.01.122_bb0005","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/378386a0","article-title":"Multiple essential functions of neuregulin in development","volume":"378","author":"Meyer","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/rp.59.1.1","article-title":"Essential roles of Her2\/erbB2 in cardiac development and function","volume":"59","author":"Negro","year":"2004","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0015","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/CIRCRESAHA.112.267286","article-title":"Neuregulin in cardiovascular development and disease","volume":"111","author":"Odiete","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0020","first-page":"1","article-title":"The roles of neuregulin-1 in cardiac development, homeostasis, and disease","volume":"10","author":"Rupert","year":"2015","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.yexcr.2005.08.017","article-title":"Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro","volume":"311","author":"Cote","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0030","doi-asserted-by":"crossref","first-page":"H2139","DOI":"10.1152\/ajpheart.00063.2012","article-title":"The role of neuregulin\/ErbB2\/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation","volume":"302","author":"Wadugu","year":"2012","journal-title":"AJP Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0035","first-page":"H2026","article-title":"NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK","volume":"277","author":"Baliga","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0040","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.bbamcr.2012.12.007","article-title":"ErbB\/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions","volume":"1833","author":"Pentassuglia","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0045","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.110.991125","article-title":"Endothelium-derived neuregulin protects the heart against ischemic injury","volume":"123","author":"Hedhli","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0050","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jcp.22354","article-title":"Expression, localization, and regulation of the neuregulin receptor ErbB3 in mouse heart","volume":"226","author":"Camprecios","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0055","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/emmm.201201553","article-title":"Alterations in cardiac DNA methylation in human dilated cardiomyopathy","volume":"5","author":"Haas","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0060","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1073\/pnas.052709799","article-title":"An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels","volume":"99","author":"Diamonti","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0065","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00395-011-0157-0","article-title":"Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury","volume":"106","author":"Zhang","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/eurjhf\/hfq152","article-title":"Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses","volume":"13","author":"Jabbour","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0075","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jacc.2009.12.044","article-title":"A phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure","volume":"55","author":"Gao","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0080","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.jacc.2006.05.057","article-title":"Neuregulin-1\/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy","volume":"48","author":"Liu","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055741","article-title":"Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1 beta improves left ventricular function, Gene and Protein expression in rats after myocardial infarction","volume":"8","author":"Hill","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0090","first-page":"807","article-title":"Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure","volume":"125","author":"Guo","year":"2012","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0095","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/MCA.0b013e32835877da","article-title":"Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction","volume":"23","author":"Xiao","year":"2012","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0100","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00395-014-0452-7","article-title":"Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning","volume":"110","author":"G.A.","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0105","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cardiores.2004.01.006","article-title":"Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion","volume":"62","author":"Kin","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0110","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-013-0400-y","article-title":"The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction","volume":"109","author":"Prunier","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0115","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/cvr\/cvq129","article-title":"Postconditioning and protection from reperfusion injury: where do we stand? Position Paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology","volume":"87","author":"Ovize","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0120","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00395-005-0543-6","article-title":"Post-conditioning reduces infarct size in the isolated rat heart: role of coronary flow and pressure and the nitric oxide\/cGMP pathway","volume":"101","author":"Penna","year":"2006","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0125","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00395-008-0731-2","article-title":"Persistent beneficial effect of postconditioning against infarct size: role of mitochondrial KATP channels during reperfusion","volume":"103","author":"Mykytenko","year":"2008","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0130","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/CIRCULATIONAHA.105.558122","article-title":"Postconditioning the human heart","volume":"112","author":"Staat","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0135","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12265-010-9252-0","article-title":"Long-term follow-up of patients undergoing postconditioning during ST-elevation myocardial infarction","volume":"4","author":"Garcia","year":"2011","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0140","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-014-0403-3","article-title":"Impact of multiple balloon inflations during primary percutaneous coronary intervention on infarct size and long-term clinical outcomes in ST-segment elevation myocardial infarction: real-world postconditioning","volume":"109","author":"Yetgin","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0145","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1111\/bph.12903","article-title":"Signalling pathways and mechanisms of protection in pre- and postconditioning: historical perspective and lessons for the future","volume":"172","author":"Cohen","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0150","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pharmthera.2008.08.002","article-title":"The myocardial JAK\/STAT pathway: from protection to failure","volume":"120","author":"Boengler","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0155","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.111.255604","article-title":"Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia\/reperfusion","volume":"109","author":"Heusch","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0891-5849(02)01179-6","article-title":"Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning","volume":"34","author":"Pagliaro","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0165","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cardiores.2007.03.001","article-title":"Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling","volume":"75","author":"Penna","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105601","article-title":"Identification and validation of suitable housekeeping genes for normalizing quantitative real-time PCR assays in injured peripheral nerves","volume":"9","author":"Gambarotta","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-1119(95)00436-A","article-title":"Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein","volume":"165","author":"Hellyer","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0180","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00424-013-1217-0","article-title":"Catestatin reduces myocardial ischaemia\/reperfusion injury: involvement of PI3K\/Akt, PKCs, mitochondrial KATP channels and ROS signalling","volume":"465","author":"Perrelli","year":"2013","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0185","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.yjmcc.2011.02.018","article-title":"Retrograde heart perfusion: the Langendorff technique of isolated heart perfusion","volume":"50","author":"Bell","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0190","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11897-010-0003-y","article-title":"Neuregulin signaling and heart failure","volume":"7","author":"Jiang","year":"2010","journal-title":"Curr. Heart Fail. Rep."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0195","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00395-005-0514-4","article-title":"Neuregulin receptors erbB2 and erbB4in failing human myocardium. Depressed expression and attenuated activation","volume":"100","author":"Rohrbach","year":"2005","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0200","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.carpath.2011.12.006","article-title":"Neuregulin-1\/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy","volume":"21","author":"Gui","year":"2012","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0205","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/CIRCRESAHA.114.303562","article-title":"Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling","volume":"114","author":"Yano","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0210","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11010-009-0377-x","article-title":"Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3??, and apoptosis","volume":"339","author":"Wagner","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0215","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1093\/emboj\/19.13.3159","article-title":"The ErbB signaling network: receptor heterodimerization in development and cancer","volume":"19","author":"Olayioye","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0220","doi-asserted-by":"crossref","first-page":"42153","DOI":"10.1074\/jbc.M102079200","article-title":"Heregulin-dependent activation of Phosphoinositide 3-kinase and Akt via the ErbB2\/ErbB3 Co-receptor","volume":"276","author":"Hellyer","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0225","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/CIRCULATIONAHA.107.690487","article-title":"Role of neuregulin-1\/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure","volume":"116","author":"Lemmens","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.01.122_bb0230","first-page":"3597","article-title":"Neuregulin-1 preconditioning protects the heart against ischemia\/reperfusion injury through a PI3K\/Akt-dependent mechanism","volume":"123","author":"Fang","year":"2010","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0235","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cjca.2014.10.035","article-title":"In situ postconditioning with neuregulin-1\u03b2 is mediated by a PI3K\/Akt-dependent pathway","volume":"31","author":"Ebner","year":"2015","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0240","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","article-title":"ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation","volume":"17","author":"T.E.","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0245","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jinorgbio.2015.09.010","article-title":"Zinc pyrithione inhibits caspase-3 activity, promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia\/reperfusion","volume":"153","author":"Bodiga","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ijcard.2017.01.122_bb0250","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.phrs.2013.11.002","article-title":"The ErbB\/HER family of protein-tyrosine kinases and cancer","volume":"79","author":"Roskoski","year":"2014","journal-title":"Pharmacol. Res."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317305521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317305521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T15:00:19Z","timestamp":1536073219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527317305521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":50,"alternative-id":["S0167527317305521"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.01.122","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial ischemia\/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.01.122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}