{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:04:22Z","timestamp":1789916662014,"version":"4.0.1"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.ijcard.2017.03.040","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:16:31Z","timestamp":1489166191000},"page":"173-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Cardiovascular and general health status of adults with Trisomy 21"],"prefix":"10.1016","volume":"241","author":[{"given":"Samuel A.","family":"Hayes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce T.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-578X","authenticated-orcid":false,"given":"Anji T.","family":"Yetman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2017.03.040_bb0005","author":"Down Syndrome"},{"key":"10.1016\/j.ijcard.2017.03.040_bb0010","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1542\/peds.2011-1605","article-title":"Clinical report\u2014health supervision for children with Down syndrome","volume":"128","author":"Bull","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijcard.2017.03.040_bb0015","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(02)08092-3","article-title":"Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study","volume":"359","author":"Yang","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2017.03.040_bb0020","first-page":"20","article-title":"Care of adults with intellectual and developmental disabilities","volume":"439","author":"Wilson","year":"2015","journal-title":"FP Essent."},{"key":"10.1016\/j.ijcard.2017.03.040_bb0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijcard.2007.02.023","article-title":"Lapse of care as a predictor for morbidity in adults with congenital heart disease","volume":"25","author":"Yeung","year":"2008","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2017.03.040_bb0030","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0002-9149(01)01596-X","article-title":"Late development of atrioventricular block after congenital heart surgery in Down syndrome","volume":"88","author":"MA Banks","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2017.03.040_bb0035","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2147\/TCRM.S10235","article-title":"Reduced exercise capacity in persons with Down syndrome: cause effect and management","volume":"6","author":"Mendonca","year":"2010","journal-title":"Ther. Clin. Risk Manag."},{"issue":"3","key":"10.1016\/j.ijcard.2017.03.040_bb0040","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/dmcn.12868","article-title":"Morbidity and medication in a large population of individuals with Down syndrome compared to the general population","volume":"58","author":"Alexander","year":"2016","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.ijcard.2017.03.040_bb0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ejim.2015.05.003","article-title":"Clinical profile and main comorbidities of Spanish Down syndrome","volume":"26","author":"Real de Asua","year":"2015","journal-title":"Eur. J. Int. Med."},{"key":"10.1016\/j.ijcard.2017.03.040_bb0050","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4093\/dmj.2014.38.6.464","article-title":"A cross-sectional study of the phenotypes of obesity and insulin resistance in adults with Down syndrome","volume":"38","author":"Real de Asua","year":"2014","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.ijcard.2017.03.040_bb0055","first-page":"5","article-title":"Intracerebral haemorrhage in Down syndrome: protected or predisposed?","volume":"12","author":"Buss","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.ijcard.2017.03.040_bb0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pjnns.2015.04.006","article-title":"Hemorrhagic stroke, cerebral amyloid angiopathy, Down syndrome and the Boston criteria","volume":"49","author":"Jastrz\u0119bski","year":"2015","journal-title":"Neurol. Neurochir. Pol."},{"key":"10.1016\/j.ijcard.2017.03.040_bb0065","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s00246-009-9442-1","article-title":"Attitude toward and current practice of transfer and transition of adolescents with congenital heart disease in the United States of America and Europe","volume":"30","author":"Hilderson","year":"2009","journal-title":"Pediatr. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316325189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316325189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T12:15:41Z","timestamp":1568895341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316325189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":13,"alternative-id":["S0167527316325189"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.03.040","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular and general health status of adults with Trisomy 21","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.03.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}