{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:46:31Z","timestamp":1773891991939,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ijcard.2017.03.056","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T15:51:09Z","timestamp":1489679469000},"page":"71-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Hopes and disappointments with antiarrhythmic drugs"],"prefix":"10.1016","volume":"237","author":[{"given":"A. John","family":"Camm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ijcard.2017.03.056_bb0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/j.1552-4604.1984.tb01822.x","article-title":"A classification of antiarrhythmic actions reassessed after a decade of new drugs","volume":"24","author":"Vaughan Williams","year":"1984","journal-title":"J. Clin. Pharmacol."},{"issue":"10","key":"10.1016\/j.ijcard.2017.03.056_bb0010","first-page":"1112","article-title":"A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. The task force of the working group on arrhythmias of the European Society of Cardiology","volume":"12","author":"The \u2018Sicilian Gambit\u2019","year":"1991","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.ijcard.2017.03.056_bb0015","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/clc.4960170307","article-title":"Antiarrhythmic drug classifications and the clinician: a gambit in the land of chaos","volume":"17","author":"Katritsis","year":"1994","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.ijcard.2017.03.056_bb0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/01.CIR.30.1.17","article-title":"Quinidine syncope. Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhyhtmias","volume":"30","author":"Selzer","year":"1964","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcard.2017.03.056_bb0025","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1056\/NEJM198908103210629","volume":"321","year":"1989","journal-title":"N. Engl. J. Med."},{"issue":"9019","key":"10.1016\/j.ijcard.2017.03.056_bb0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(96)02149-6","article-title":"Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD investigators. Survival with oral d-sotalol","volume":"348","author":"Waldo","year":"1996","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ijcard.2017.03.056_bb0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0002-9149(93)90673-Z","volume":"72","year":"1993","journal-title":"Am. J. Cardiol."},{"issue":"9053","key":"10.1016\/j.ijcard.2017.03.056_bb0040","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0140-6736(96)08171-8","article-title":"Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Canadian amiodarone myocardial infarction arrhythmia trial investigators","volume":"349","author":"Cairns","year":"1997","journal-title":"Lancet"},{"issue":"9089","key":"10.1016\/j.ijcard.2017.03.056_bb0045","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(97)05281-1","volume":"350","year":"1997","journal-title":"Lancet"},{"issue":"17","key":"10.1016\/j.ijcard.2017.03.056_bb0050","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1161\/01.CIR.99.17.2268","article-title":"Amiodarone interaction with beta-blockers: analysis of the merged EMIAT (European myocardial infarct amiodarone trial) and CAMIAT (Canadian amiodarone myocardial infarction trial) databases. The EMIAT and CAMIAT investigators","volume":"99","author":"Boutitie","year":"1999","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.ijcard.2017.03.056_bb0055","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1056\/NEJM199711273372202","volume":"337","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.ijcard.2017.03.056_bb0060","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1161\/01.CIR.101.11.1297","article-title":"Canadian implantable defibrillator study (CIDS): a randomized trial of the implantable cardioverter defibrillator against amiodarone","volume":"101","author":"Connolly","year":"2000","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ijcard.2017.03.056_bb0065","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/01.CIR.102.7.748","article-title":"Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg (CASH)","volume":"102","author":"Kuck","year":"2000","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.ijcard.2017.03.056_bb0070","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa013474","article-title":"Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction","volume":"346","author":"Moss","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.ijcard.2017.03.056_bb0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa043399","article-title":"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure","volume":"352","author":"Bardy","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.ijcard.2017.03.056_bb0080","doi-asserted-by":"crossref","first-page":"e247","DOI":"10.1016\/j.jacc.2006.07.010","volume":"48","author":"European Heart Rhythm Association","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.ijcard.2017.03.056_bb0085","first-page":"1601","volume":"17","author":"Priori","year":"2015","journal-title":"Europace"},{"issue":"13","key":"10.1016\/j.ijcard.2017.03.056_bb0090","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMoa1608029","article-title":"Defibrillator implantation in patients with nonischemic systolic heart failure","volume":"375","author":"K\u00f8ber","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.ijcard.2017.03.056_bb0095","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/01.CIR.0000117090.01718.2A","article-title":"Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification","volume":"109","author":"Camm","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcard.2017.03.056_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10840-011-9636-3","article-title":"A randomized trial of budiodarone in paroxysmal atrial fibrillation","volume":"34","author":"Ezekowitz","year":"2012","journal-title":"J. Interv. Card. Electrophysiol."},{"issue":"7","key":"10.1016\/j.ijcard.2017.03.056_bb0105","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMoa0803778","article-title":"Effect of dronedarone on cardiovascular events in atrial fibrillation","volume":"360","author":"Hohnloser","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ijcard.2017.03.056_bb0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jacc.2004.03.047","article-title":"Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter","volume":"44","author":"Hohnloser","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"issue":"15","key":"10.1016\/j.ijcard.2017.03.056_bb0115","first-page":"2701","article-title":"Ibutilide decreases defibrillation threshold by the reduction of activation pattern complexity during ventricular fibrillation in canine hearts","volume":"125","author":"Jin","year":"2012","journal-title":"Chin. Med. J."},{"issue":"10","key":"10.1016\/j.ijcard.2017.03.056_bb0120","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/jce.13029","article-title":"Ranolazine and Vernakalant prevent ventricular arrhythmias in an experimental whole-heart model of short QT syndrome","volume":"27","author":"Frommeyer","year":"2016","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"3","key":"10.1016\/j.ijcard.2017.03.056_bb0125","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/europace\/eus400","article-title":"The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: effect of ranolazine","volume":"15","author":"Karwatowska-Prokopczuk","year":"2013","journal-title":"Europace"},{"issue":"3","key":"10.1016\/j.ijcard.2017.03.056_bb0130","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.hrthm.2016.10.021","article-title":"Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model","volume":"14","author":"Bacic","year":"2017","journal-title":"Heart Rhythm."},{"issue":"6A","key":"10.1016\/j.ijcard.2017.03.056_bb0135","doi-asserted-by":"crossref","first-page":"40D","DOI":"10.1016\/S0002-9149(98)00152-0","article-title":"Azimilide dihydrochloride, a novel antiarrhythmic agent","volume":"81","author":"Karam","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2017.03.056_bb0145","author":"RAID trial"},{"key":"10.1016\/j.ijcard.2017.03.056_bb0150","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ahj.2016.10.025","article-title":"Results of a curtailed randomized controlled trial, evaluating the efficacy and safety of azimilide in patients with implantable cardioverter-defibrillators: the SHIELD-2 trial","volume":"185","author":"Robinson","year":"2017","journal-title":"Am. Heart J."},{"issue":"11","key":"10.1016\/j.ijcard.2017.03.056_bb0155","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"18","author":"Kirchhof","year":"2016","journal-title":"Europace"},{"issue":"4 Suppl","key":"10.1016\/j.ijcard.2017.03.056_bb0160","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1542-474X.2005.00077.x","article-title":"Safety and efficacy of flecainide in subjects with long QT-3 syndrome (DeltaKPQ mutation): a randomized, double-blind, placebo-controlled clinical trial","volume":"10","author":"Moss","year":"2005","journal-title":"Ann. Noninvasive Electrocardiol."},{"issue":"12","key":"10.1016\/j.ijcard.2017.03.056_bb0165","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1540-8167.2008.01246.x","article-title":"Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome","volume":"19","author":"Moss","year":"2008","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"19","key":"10.1016\/j.ijcard.2017.03.056_bb0170","doi-asserted-by":"crossref","first-page":"9005","DOI":"10.1021\/acs.jmedchem.6b00939","article-title":"Discovery of dihydrobenzoxazepinone (GS-6615) late sodium current inhibitor (late I(Na)i), a phase II agent with demonstrated preclinical anti-ischemic and antiarrhythmic properties","volume":"59","author":"Zablocki","year":"2016","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.ijcard.2017.03.056_bb0175","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.hrthm.2012.01.010","article-title":"Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2","volume":"9","author":"Parikh","year":"2012","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2017.03.056_bb0180","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fphar.2012.00062","article-title":"Mexiletine differentially restores the trafficking defects caused by two Brugada syndrome mutations","volume":"3","author":"Moreau","year":"2012","journal-title":"Front. Pharmacol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317316649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317316649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T09:23:55Z","timestamp":1535966635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527317316649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":35,"alternative-id":["S0167527317316649"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.03.056","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hopes and disappointments with antiarrhythmic drugs","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.03.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}