{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:10:16Z","timestamp":1776363016541,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.ijcard.2017.05.088","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T12:15:28Z","timestamp":1495628128000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction"],"prefix":"10.1016","volume":"243","author":[{"given":"M.","family":"Hortmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Haenel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mauler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Stallmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Reinoehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Duerschmied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2017.05.088_bb0005","first-page":"774","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge","volume":"38","author":"Heusch","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0010","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0015","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1161\/CIRCRESAHA.116.308640","article-title":"The coronary circulation as a target of cardioprotection","volume":"118","author":"Heusch","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0020","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1161\/01.CIR.99.15.1972","article-title":"Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome","volume":"99","author":"Claeys","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/2048872615570770","article-title":"Adiponectin and ischemia-reperfusion injury in ST segment elevation myocardial infarction","volume":"5","author":"De Roeck","year":"2016","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0030","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/01.CIR.0000118496.44135.A7","article-title":"Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction","volume":"109","author":"Bolognese","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0035","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jacc.2014.06.1194","article-title":"Comprehensive prognosis assessment by CMR imaging after ST-segment elevation myocardial infarction","volume":"64","author":"Eitel","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0040","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1161\/01.CIR.0000070423.91346.45","article-title":"Incomplete resolution of ST-segment elevation is a marker of transient microcirculatory dysfunction after stenting for acute myocardial infarction","volume":"107","author":"Feldman","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0045","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","article-title":"Evolving therapies for myocardial ischemia\/reperfusion injury","volume":"65","author":"Ibanez","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0050","first-page":"8786","article-title":"Acute myocardial infarction and myocardial ischemia-reperfusion injury: a comparison","volume":"8","author":"Hashmi","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0055","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/cvr\/cvm005","article-title":"Heart mitochondria: gates of life and death","volume":"77","author":"Gustafsson","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0060","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2217\/fca.12.58","article-title":"Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species","volume":"8","author":"Webster","year":"2012","journal-title":"Future Cardiol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1755-5922.2008.00052.x","article-title":"Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia\/reperfusion injury","volume":"26","author":"Bhuiyan","year":"2008","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0070","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/01.CIR.0000151613.90994.17","article-title":"Role of Omi\/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion","volume":"111","author":"Liu","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0075","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11357-012-9406-x","article-title":"Variations in the protein level of Omi\/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia\/reperfusion injury and cell death: Omi\/HtrA2 and aged heart injury","volume":"35","author":"Wang","year":"2013","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2006.10.067","article-title":"Inhibition of HtrA2\/Omi ameliorates heart dysfunction following ischemia\/reperfusion injury in rat heart in vivo","volume":"557","author":"Bhuiyan","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0085","doi-asserted-by":"crossref","first-page":"37927","DOI":"10.1038\/srep37927","article-title":"Cardiac specific overexpression of mitochondrial Omi\/HtrA2 induces myocardial apoptosis and cardiac dysfunction","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/MCA.0000000000000040","article-title":"Cytochrome c release in acute myocardial infarction predicts poor prognosis and myocardial reperfusion on contrast-enhanced magnetic resonance imaging","volume":"25","author":"Liu","year":"2014","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0095","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.amjcard.2010.07.014","article-title":"Circulating cytochrome c as potential biomarker of impaired reperfusion in ST-segment elevation acute myocardial infarction","volume":"106","author":"Marenzi","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0100","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1161\/CIRCULATIONAHA.108.767772","article-title":"ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the assessment of Pexelizumab in acute myocardial infarction (APEX-AMI) trial","volume":"118","author":"Buller","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0105","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","article-title":"ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"33","author":"Steg","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0110","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/eurheartj\/ehr236","volume":"32","author":"Hamm","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0115","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jacc.2015.10.081","article-title":"Cyclosporine a in Reperfused myocardial infarction: the multicenter, controlled, open-label CYCLE trial","volume":"67","author":"Ottani","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0120","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/sj.cdd.4400981","article-title":"Release of intact, monomeric cytochrome c from apoptotic and necrotic cells","volume":"9","author":"Jemmerson","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0125","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1136\/heartjnl-2015-307804","article-title":"Targeting reperfusion injury in the era of primary percutaneous coronary intervention: hope or hype?","volume":"101","author":"Lonborg","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2017.05.088_bb0130","first-page":"935","article-title":"Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations","volume":"38","author":"Hausenloy","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0135","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJMoa071142","article-title":"Effect of cyclosporine on reperfusion injury in acute myocardial infarction","volume":"359","author":"Piot","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0140","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJMoa1505489","article-title":"Cyclosporine before PCI in patients with acute myocardial infarction","volume":"373","author":"Cung","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0145","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/eurheartj\/ehv597","article-title":"EMBRACE STEMI study: a phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention","volume":"37","author":"Gibson","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0150","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/CIRCRESAHA.116.308736","article-title":"Time to give up on Cardioprotection? A critical appraisal of clinical studies on ischemic pre-, post-, and remote conditioning","volume":"119","author":"Heusch","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0155","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/0735-1097(95)00372-X","volume":"26","author":"Schroder","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00395-015-0478-5","article-title":"Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury","volume":"110","author":"Baker","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2017.05.088_bb0165","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00395-015-0479-4","article-title":"A long way to translation: will cMyC survive?","volume":"110","author":"Giannitsis","year":"2015","journal-title":"Basic Res. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316341262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527316341262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T14:20:06Z","timestamp":1535811606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527316341262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":33,"alternative-id":["S0167527316341262"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.05.088","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating HtrA2 as a novel biomarker for mitochondrial induced cardiomyocyte apoptosis and ischemia-reperfusion injury in ST-segment elevation myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2017.05.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}