{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:45:44Z","timestamp":1791773144961,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ijcard.2018.01.097","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T20:25:46Z","timestamp":1526415946000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Incidence of bleeding in patients with atrial fibrillation and advanced liver fibrosis on treatment with vitamin K or non-vitamin K antagonist oral anticoagulants"],"prefix":"10.1016","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-5213","authenticated-orcid":false,"given":"Daniele","family":"Pastori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7104-5826","authenticated-orcid":false,"given":"Alessio","family":"Farcomeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Del Sole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sciacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perticone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Grifoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Saliola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Casciaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Menichelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cribari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Paladino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony","family":"Gingis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Novo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Cammisotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nocella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bartimoccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Iannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Sabbatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Anastasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Tassone","family":"Eliezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.01.097_bb0005","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0010","article-title":"Ankle-Brachial Index and cardiovascular events in atrial fibrillation. The ARAPACIS Study","volume":"115","author":"Violi","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0015","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.14-2414","article-title":"Incidence of myocardial infarction and vascular death in elderly patients with atrial fibrillation taking anticoagulants: relation to atherosclerotic risk factors","volume":"147","author":"Pastori","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0020","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","volume":"37","author":"Kirchhof","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0025","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1160\/TH08-11-0730","article-title":"Bleeding with anticoagulation therapy - who is at risk, and how best to identify such patients","volume":"102","author":"Palareti","year":"2009","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0030","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/jamaneurol.2017.0923","article-title":"Association between cirrhosis and stroke in a nationally representative cohort","volume":"74","author":"Parikh","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0040","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1161\/STROKEAHA.111.617076","article-title":"Liver cirrhosis and risk of intracerebral hemorrhage: a 9-year follow-up study","volume":"42","author":"Lai","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0045","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005307","article-title":"Liver cirrhosis in patients with atrial fibrillation: would oral anticoagulation have a net clinical benefit for stroke prevention?","volume":"6","author":"Kuo","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0050","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1053\/j.gastro.2017.04.042","article-title":"Effects of anticoagulants in patients with cirrhosis and portal vein thrombosis: a systematic review and meta-analysis","volume":"153","author":"Loffredo","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0055","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/hep.29113","article-title":"Liver fibrosis scores predict liver disease mortality in the United States population","volume":"66","author":"Unalp-Arida","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0060","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/hep.26156","article-title":"Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States","volume":"57","author":"Kim","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0065","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2893.2009.01150.x","article-title":"Implication of normal liver enzymes in liver disease","volume":"16","author":"Calvaruso","year":"2009","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0070","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1055\/s-0038-1651587","article-title":"A method to determine the optimal intensity of oral anticoagulant therapy","volume":"69","author":"Rosendaal","year":"1993","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0075","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1097\/HJH.0b013e328364ca4c","article-title":"2013 practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH\/ESC Task Force for the Management of Arterial Hypertension","volume":"31","author":"Mancia","year":"2013","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0080","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/eurheartj\/eht108","volume":"34","author":"Authors\/Task Force M","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0085","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/eurjhf\/hfs033","volume":"14","author":"McMurray","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0090","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/liv.13549","article-title":"Steatosis severity affects the diagnostic performances of noninvasive fibrosis tests in nonalcoholic fatty liver disease","volume":"38","author":"Joo","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0100","article-title":"Evaluation of APRI and FIB-4 for noninvasive assessment of significant fibrosis and cirrhosis in HBeAg-negative CHB patients with ALT\u202f\u2264\u202f2 ULN: a retrospective cohort study","volume":"96","author":"Li","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0105","series-title":"Data Brief","article-title":"Data on incidence of bleeding in patients with atrial fibrillation and advanced liver fibrosis on treatment with vitamin K or non-vitamin K antagonists oral anticoagulants","author":"Pastori","year":"2018"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0110","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijcard.2014.11.183","article-title":"The safety and efficacy of vitamin K antagonist in patients with atrial fibrillation and liver cirrhosis","volume":"180","author":"Lee","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0115","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/CIRCOUTCOMES.113.000817","article-title":"Stratifying the risks of oral anticoagulation in patients with liver disease","volume":"7","author":"Efird","year":"2014","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0120","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(96)01109-9","article-title":"Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy","volume":"348","author":"Palareti","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0125","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ahj.2004.11.015","article-title":"Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study","volume":"149","author":"DiMarco","year":"2005","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0130","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/jamainternmed.2015.90","article-title":"Should the term coagulopathy in cirrhosis be abandoned?","volume":"175","author":"Violi","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0135","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/s-0033-1334144","article-title":"Clotting activation and hyperfibrinolysis in cirrhosis: implication for bleeding and thrombosis","volume":"39","author":"Violi","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0140","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.blre.2014.10.002","article-title":"Is there a rationale for treatment of chronic liver disease with antithrombotic therapy?","volume":"29","author":"Hugenholtz","year":"2015","journal-title":"Blood Rev."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0145","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.3324\/haematol.2015.139972","article-title":"Endotoxemia as a trigger of thrombosis in cirrhosis","volume":"101","author":"Violi","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11739-014-1163-7","article-title":"Epidemiology of venous thromboembolism in patients with liver diseases: a systematic review and meta-analysis","volume":"10","author":"Qi","year":"2015","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5551\/jat.35121","article-title":"Anticoagulation stability depends on CHADS2 score and hepatorenal function in warfarin-treated patients, including those with atrial fibrillation","volume":"24","author":"Odashiro","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0160","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1111\/j.1538-7836.2010.03996.x","article-title":"Patient characteristics associated with oral anticoagulation control: results of the Veterans AffaiRs Study to Improve Anticoagulation (VARIA)","volume":"8","author":"Rose","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0165","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/hep.510240613","article-title":"Prothrombin time in liver failure: time, ratio, activity percentage, or international normalized ratio?","volume":"24","author":"Robert","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0170","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1055\/s-0038-1642513","article-title":"Assessment of the validity of the INR system for patients with liver impairment","volume":"71","author":"Kovacs","year":"1994","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0175","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/hep.21732","article-title":"The international normalized ratio calibrated for cirrhosis (INR(liver)) normalizes prothrombin time results for model for end-stage liver disease calculation","volume":"46","author":"Tripodi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0180","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/hep.25623","article-title":"Dismantling the myth of \u201cautoanticoagulation\u201d in cirrhosis: an old dogma dies hard","volume":"55","author":"Caldwell","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tcm.2014.09.001","article-title":"Warfarin pharmacogenetics","volume":"25","author":"Johnson","year":"2015","journal-title":"Trends Cardiovasc. Med."},{"issue":"Suppl. 3","key":"10.1016\/j.ijcard.2018.01.097_bb0190","doi-asserted-by":"crossref","first-page":"S297","DOI":"10.1007\/s11739-012-0826-5","article-title":"Nonalcoholic fatty liver disease and atherosclerosis","volume":"7","author":"Gaudio","year":"2012","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.ijcard.2018.01.097_bb0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/hep.28776","article-title":"Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease","volume":"65","author":"Ajmera","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.ijcard.2018.01.097_bb0200","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1136\/gut.2010.216077","article-title":"Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease","volume":"59","author":"McPherson","year":"2010","journal-title":"Gut"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317376830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317376830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:39:28Z","timestamp":1759091968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527317376830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":40,"alternative-id":["S0167527317376830"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.01.097","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence of bleeding in patients with atrial fibrillation and advanced liver fibrosis on treatment with vitamin K or non-vitamin K antagonist oral anticoagulants","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.01.097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}