{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:14:20Z","timestamp":1780733660286,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.ijcard.2018.01.136","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T08:27:41Z","timestamp":1517560061000},"page":"138-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Aortic stenosis and aortic regurgitation express different titin isoforms: Differences and relationships with functional and geometric characteristics"],"prefix":"10.1016","volume":"259","author":[{"given":"Vito","family":"Mannacio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Mannacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Antignano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"De Amicis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Musumeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Iannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.01.136_bb0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0008-6363(99)00268-0","article-title":"The role of the cytoskeleton in heart failure","volume":"45","author":"Heina","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0010","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1161\/CIRCULATIONAHA.106.620765","article-title":"New molecular mechanism in diastolic heart failure","volume":"113","author":"Katz","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0015","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/jappl.2000.88.3.1127","article-title":"Form follows function: how muscle shape is regulated by work","volume":"88","author":"Russell","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/01.RES.86.1.59","article-title":"Differential expression of cardiac titin isoforms and modulation of cellular stiffness","volume":"86","author":"Cazorla","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0025","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1161\/CIRCULATIONAHA.109.860171","article-title":"Cardiac Titin: a multifunctional giant","volume":"121","author":"LeWinter","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2006.06.035","article-title":"Cardiac titin: structure, functions and role in disease","volume":"375","author":"LeWinter","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0035","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1590\/S0066-782X2011005000023","article-title":"The role of titin in the modulation of cardiac function and its pathophysiological implications","volume":"96","author":"Castro-Ferreira","year":"2011","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0040","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/01.CIR.0000029804.61510.02","article-title":"Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness","volume":"106","author":"Wu","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0045","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0008-6363(03)00328-6","article-title":"Titin isoform expression in normal and hypertensive myocardium","volume":"59","author":"Warren","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0050","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/01.CIR.0000029803.93022.93","article-title":"Titin isoform switch in ischemic human heart disease","volume":"106","author":"Neagoe","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0055","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/01.CIR.0000135591.37759.AF","article-title":"Altered titin expression myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy","volume":"110","author":"Nagueh","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10974-005-9038-1","article-title":"Titin\/connectin-based modulation of the frank-Starling mechanism of the heart","volume":"26","author":"Fukuda","year":"2005","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000431283","article-title":"Comparison of left ventricular myocardial structure and function in patients with aortic stenosis and those with pure aortic regurgitation","volume":"132","author":"Mannacio","year":"2015","journal-title":"Cardiology"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0070","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCULATIONAHA.111.025270","article-title":"Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness","volume":"124","author":"Falc\u00e3o-Pires","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0075","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1042\/CS20080248","article-title":"Titin isoform expression in aortic stenosis","volume":"117","author":"Williams","year":"2009","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0080","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1161\/CIRCULATIONAHA.106.176857","article-title":"ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease","volume":"114","author":"Bonow","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0085","first-page":"409","article-title":"64-slice multidetector computed tomographic evaluation of arterial conduit patency after off-pump coronary artery bypass grafting","volume":"36","author":"Mannacio","year":"2009","journal-title":"Tex. Heart Inst. J."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ejechocard\/jen303","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"10","author":"Baumgartner","year":"2009","journal-title":"Eur. J. Echocardiogr."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0095","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euje.2005.12.014","article-title":"Recommendations for chamber quantification","volume":"7","author":"Lang","year":"2006","journal-title":"Eur. J. Echocardiogr."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0105","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.jacc.2011.07.022","article-title":"Left ventricular structural remodeling in health and disease","volume":"58","author":"Gaasch","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"22","author":"Nagueh","year":"2009","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"11","key":"10.1016\/j.ijcard.2018.01.136_bb0115","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/01.CIR.0000155257.33485.6D","article-title":"Cardiomyocyte stiffness in diastolic heart failure","volume":"15","author":"Borb\u00e9ly","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.01.136_bb0120","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/cvr\/cvs353","article-title":"Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction","volume":"97","author":"Hamdani","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2018.01.136_bb0125","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cjca.2014.04.026","article-title":"Left ventricular remodelling in aortic stenosis","volume":"30","author":"Rassi","year":"2014","journal-title":"Can. J. Cardiol."},{"issue":"6","key":"10.1016\/j.ijcard.2018.01.136_bb0130","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1161\/CIRCRESAHA.108.193326","article-title":"Hypophosphorylation of the stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium","volume":"104","author":"Borb\u00e9ly","year":"2009","journal-title":"Circ. Res."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317328243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317328243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T12:57:57Z","timestamp":1547557077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527317328243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":26,"alternative-id":["S0167527317328243"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.01.136","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aortic stenosis and aortic regurgitation express different titin isoforms: Differences and relationships with functional and geometric characteristics","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.01.136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}