{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:09:19Z","timestamp":1791835759406,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570400"],"award-info":[{"award-number":["81570400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670411"],"award-info":[{"award-number":["81670411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702194"],"award-info":[{"award-number":["81702194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471036"],"award-info":[{"award-number":["81471036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600633"],"award-info":[{"award-number":["81600633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470560"],"award-info":[{"award-number":["81470560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HQ037"],"award-info":[{"award-number":["ZR2014HQ037"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017BH023"],"award-info":[{"award-number":["ZR2017BH023"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["Y2005C61"],"award-info":[{"award-number":["Y2005C61"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2017GSF18156"],"award-info":[{"award-number":["2017GSF18156"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ijcard.2018.04.028","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T02:30:09Z","timestamp":1523241009000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE\u2212\/\u2212 mice"],"prefix":"10.1016","volume":"265","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-yuan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.04.028_bb0005","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fphys.2015.00304","article-title":"Adipokines, diabetes and atherosclerosis: an inflammatory association","volume":"6","author":"Freitas Lima","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2840-3-1","article-title":"Vasa vasorum in plaque angiogenesis, metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: a malignant transformation","volume":"3","author":"Hayden","year":"2004","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14712\/23362936.2015.49","article-title":"Adipose tissue as an endocrine organ: an update on pro-inflammatory and anti-inflammatory microenvironment","volume":"116","author":"Smitka","year":"2015","journal-title":"Prague Med. Rep."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/157016109787455680","article-title":"Visceral adipose tissue and atherosclerosis","volume":"7","author":"Ohman","year":"2009","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0025","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/S0140-6736(08)60768-0","article-title":"Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies","volume":"371","author":"Mazzone","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0030","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrd3444","article-title":"Anti-inflammatory therapeutics for the treatment of atherosclerosis","volume":"10","author":"Charo","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0035","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-physiol-021115-104929","article-title":"Exosomes: fundamental biology and roles in cardiovascular physiology","volume":"78","author":"Ibrahim","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0045","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1002\/oby.20847","article-title":"Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells","volume":"22","author":"Kranendonk","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3410\/B3-15","article-title":"Exosomes: secreted vesicles and intercellular communications","volume":"3","author":"Thery","year":"2011","journal-title":"F1000 Biol. Rep."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0060","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0065","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrcardio.2017.7","article-title":"Extracellular vesicles in coronary artery disease","volume":"14","author":"Boulanger","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0070","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.jacc.2008.09.055","article-title":"The pathologic continuum of diabetic vascular disease","volume":"53","author":"Orasanu","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0075","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1160\/TH06-12-0742","article-title":"Vasa vasorum and atherosclerosis - Quid novi?","volume":"97","author":"Langheinrich","year":"2007","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0080","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.jacc.2007.01.089","article-title":"Plaque neovascularization and antiangiogenic therapy for atherosclerosis","volume":"49","author":"Doyle","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/22115528113020020001","article-title":"Exosomes function in pro- and anti-angiogenesis","volume":"2","author":"Ribeiro","year":"2013","journal-title":"Curr. Angiogenes"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0090","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3389\/fimmu.2014.00608","article-title":"Extracellular vesicles: potential roles in regenerative medicine","volume":"5","author":"De Jong","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/cpr.12233","article-title":"Physiological and pathological impact of exosomes of adipose tissue","volume":"49","author":"Zhang","year":"2016","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0100","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/CIRCULATIONAHA.106.619213","article-title":"Hedgehog morphogen in cardiovascular disease","volume":"114","author":"Bijlsma","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0105","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1161\/CIRCULATIONAHA.105.603167","article-title":"Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling","volume":"113","author":"Asai","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0110","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/89083","article-title":"The morphogen sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors","volume":"7","author":"Pola","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0115","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1101\/gad.1693608","article-title":"Hedgehog: functions and mechanisms","volume":"22","author":"Varjosalo","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0120","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1038\/srep07357","article-title":"Vertebrate hedgehog is secreted on two types of extracellular vesicles with different signaling properties","volume":"4","author":"Vyas","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/srep23479","article-title":"Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway","volume":"6","author":"Fleury","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0130","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1161\/CIRCRESAHA.116.305012","article-title":"Vascular smooth muscle cell calcification is mediated by regulated exosome secretion","volume":"116","author":"Kapustin","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0135","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/carcin\/bgp030","article-title":"Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors","volume":"30","author":"Soleti","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0140","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/pr.2014.202","article-title":"Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease","volume":"77","author":"Ferrante","year":"2015","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0145","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s10930-015-9616-z","article-title":"Proteomic analysis of extracellular vesicles released by adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats","volume":"34","author":"Lee","year":"2015","journal-title":"Protein J."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0150","doi-asserted-by":"crossref","first-page":"6S77","DOI":"10.1016\/S1262-3636(03)72791-8","article-title":"Microcirculation in insulin resistance and diabetes: more than just a complication","volume":"29","author":"Wiernsperger","year":"2003","journal-title":"Diabete Metab."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/659890","article-title":"Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction","volume":"2015","author":"Kang","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0160","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.febslet.2015.03.031","article-title":"Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration","volume":"589","author":"Nakamura","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0165","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/B978-0-12-394622-5.00018-3","article-title":"Sonic Hedgehog on microparticles and neovascularization","volume":"88","author":"Soleti","year":"2012","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0170","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1073\/pnas.0711382105","article-title":"A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells","volume":"105","author":"Passman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2018.04.028_bb0175","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/bies.201200049","article-title":"Hedgehog signalling as an antagonist of ageing and its associated diseases","volume":"34","author":"Dashti","year":"2012","journal-title":"BioEssays"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0180","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cell.2009.12.027","article-title":"Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate","volume":"140","author":"Pospisilik","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0185","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1634\/stemcells.2007-0974","article-title":"Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells","volume":"26","author":"Fontaine","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijcard.2018.04.028_bb0190","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.biochi.2007.08.012","article-title":"Hedgehog and adipogenesis: fat and fiction","volume":"89","author":"Cousin","year":"2007","journal-title":"Biochimie"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318301141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318301141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:38:37Z","timestamp":1759091917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318301141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":38,"alternative-id":["S0167527318301141"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.04.028","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE\u2212\/\u2212 mice","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}