{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:34:25Z","timestamp":1790721265710,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ijcard.2018.04.082","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T07:17:03Z","timestamp":1530343023000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Hyperglycaemia-induced epigenetic changes drive persistent cardiac dysfunction via the adaptor p66Shc"],"prefix":"10.1016","volume":"268","author":[{"given":"Sarah","family":"Costantino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Paneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5545-5630","authenticated-orcid":false,"given":"Katharyn","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafeeq A.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafaat","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Gkolfos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liberato","family":"Berrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-8380","authenticated-orcid":false,"given":"Massimo","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Schwarzwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Felix","family":"L\u00fcscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.04.082_bb0005","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2337\/diacare.27.8.1879","article-title":"The incidence of congestive heart failure in type 2 diabetes: an update","volume":"27","author":"Nichols","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jchf.2014.08.004","article-title":"Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure","volume":"3","author":"Dei Cas","year":"2015","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0015","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/eurheartj\/ehv134","article-title":"Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes","volume":"36","author":"Seferovic","year":"2015","journal-title":"Eur Heart J."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0020","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1161\/01.CIR.103.22.2668","article-title":"Glycemic control and heart failure among adult patients with diabetes","volume":"103","author":"Iribarren","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0025","doi-asserted-by":"crossref","first-page":"50B","DOI":"10.1016\/j.amjcard.2012.08.031","article-title":"Congestive heart failure and diabetes mellitus: balancing glycemic control with heart failure improvement","volume":"110","author":"Nasir","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0030","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ahj.2011.07.030","article-title":"Intensive glycemic control has no impact on the risk of heart failure in type 2 diabetic patients: evidence from a 37,229 patient meta-analysis","volume":"162","author":"Castagno","year":"2011","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0035","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijcard.2016.04.163","article-title":"Effects of intensive glucose lowering in treatment of type 2 diabetes mellitus on cardiovascular outcomes: a meta-analysis of data from 58,160 patients in 13 randomized controlled trials","volume":"218","author":"Fang","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0040","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0045","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0050","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1093\/eurheartj\/ehv305","article-title":"Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications","volume":"36","author":"Munzel","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0055","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1089\/ars.2015.6349","article-title":"Diabetic cardiomyopathy and the role of mitochondrial dysfunction: novel insights, mechanisms, and therapeutic strategies","volume":"22","author":"Aon","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0060","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/CIRCRESAHA.116.306819","article-title":"Epigenetic changes in diabetes and cardiovascular risk","volume":"118","author":"Keating","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0065","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/138920101606150407113644","article-title":"Targeting chromatin remodeling to prevent cardiovascular disease in diabetes","volume":"16","author":"Costantino","year":"2015","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0070","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","article-title":"Epigenetic modifications: basic mechanisms and role in cardiovascular disease","volume":"123","author":"Handy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0075","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCRESAHA.116.303549","article-title":"Long noncoding RNAs and microRNAs in cardiovascular pathophysiology","volume":"116","author":"Thum","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4161\/epi.26405","article-title":"Interplay of chromatin modifications and non-coding RNAs in the heart","volume":"9","author":"Mathiyalagan","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0085","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCGENETICS.110.958744","article-title":"Cardiovascular epigenetics: basic concepts and results from animal and human studies","volume":"3","author":"Baccarelli","year":"2010","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0090","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/46311","article-title":"The p66shc adaptor protein controls oxidative stress response and life span in mammals","volume":"402","author":"Migliaccio","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0095","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/ATVBAHA.107.156059","article-title":"Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein","volume":"28","author":"Cosentino","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0100","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.2337\/db12-1648","article-title":"SIRT1, p66(Shc), and Set7\/9 in vascular hyperglycemic memory: bringing all the strands together","volume":"62","author":"Paneni","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2005.05.011","article-title":"Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis","volume":"122","author":"Giorgio","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0110","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1093\/eurheartj\/eht149","article-title":"Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I","volume":"34","author":"Paneni","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0115","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/eurheartj\/ehu400","article-title":"Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways","volume":"36","author":"Akhmedov","year":"2015","journal-title":"Eur. Heart J."},{"issue":"19","key":"10.1016\/j.ijcard.2018.04.082_bb0120","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/eurheartj\/ehv728","article-title":"Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME(R) trial","volume":"37","author":"Fitchett","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0125","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/CIRCULATIONAHA.113.005081","article-title":"Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus","volume":"129","author":"Cherney","year":"2014","journal-title":"Circulation"},{"issue":"Suppl. 1","key":"10.1016\/j.ijcard.2018.04.082_bb0130","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0168-8227(09)70002-6","article-title":"Hypothesis: the \"metabolic memory\", the new challenge of diabetes","volume":"86","author":"Ceriello","year":"2009","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.atherosclerosis.2013.07.003","article-title":"Epigenetic signatures and vascular risk in type 2 diabetes: a clinical perspective","volume":"230","author":"Paneni","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0140","doi-asserted-by":"crossref","first-page":"851","DOI":"10.15252\/emmm.201100899","article-title":"Development of microRNA therapeutics is coming of age","volume":"6","author":"van Rooij","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050536","article-title":"MicroRNA 218 mediates the effects of Tbx5a over-expression on zebrafish heart development","volume":"7","author":"Chiavacci","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0150","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/dev.060046","article-title":"A Slit\/miR-218\/Robo regulatory loop is required during heart tube formation in zebrafish","volume":"138","author":"Fish","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ijcard.2018.04.082_bb0155","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1161\/CIRCRESAHA.110.227926","article-title":"MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling","volume":"107","author":"Small","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature11919","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"495","author":"Boon","year":"2013","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ijcard.2018.04.082_bb0165","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.2337\/db17-0294","article-title":"Impact of glycemic variability on chromatin remodeling, oxidative stress and endothelial dysfunction in type 2 diabetic patients with target HbA1c levels","volume":"66","author":"Costantino","year":"2017","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.ijcard.2018.04.082_bb0170","doi-asserted-by":"crossref","first-page":"8891","DOI":"10.1007\/s11033-012-1756-z","article-title":"High levels of glucose induce \"metabolic memory\" in cardiomyocyte via epigenetic histone H3 lysine 9 methylation","volume":"39","author":"Yu","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ijcard.2018.04.082_bb0175","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCRESAHA.116.305432","article-title":"Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases","volume":"116","author":"Kornfeld","year":"2015","journal-title":"Circ. Res."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318307745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318307745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:39:08Z","timestamp":1759091948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318307745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":35,"alternative-id":["S0167527318307745"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.04.082","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperglycaemia-induced epigenetic changes drive persistent cardiac dysfunction via the adaptor p66Shc","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.04.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}