{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:58:25Z","timestamp":1790740705854,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"KAKENHI","award":["16K09522"],"award-info":[{"award-number":["16K09522"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ijcard.2018.05.072","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T21:48:01Z","timestamp":1528235281000},"page":"221-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation"],"prefix":"10.1016","volume":"270","author":[{"given":"Kikuo","family":"Isoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Akita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Sato-Okabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyasu","family":"Kadoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarasa","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Ohtomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoaki","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9934-5775","authenticated-orcid":false,"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Daida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.05.072_bb0005","first-page":"11","article-title":"Abdominal aortic aneurysm: a comprehensive review","volume":"16","author":"Aggarwal","year":"2011","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0010","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1111\/febs.13634","article-title":"Atherosclerosis and aortic aneurysm - is inflammation a common denominator?","volume":"283","author":"Peshkova","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/01.HYP.34.1.113","article-title":"Preactivated peripheral blood monocytes in patients with essential hypertension","volume":"34","author":"Dorffel","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2018.05.072_bb0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2362.2001.00743.x","article-title":"Pro-inflammatory cytokines in patients with essential hypertension","volume":"31","author":"Peeters","year":"2001","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.HYP.38.3.399","article-title":"Blood pressure and inflammation in apparently healthy men","volume":"38","author":"Chae","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2018.05.072_bb0030","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1210\/jcem.86.3.7305","article-title":"Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women","volume":"86","author":"Fernandez-Real","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0035","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/HYPERTENSIONAHA.110.158071","article-title":"Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2\/signal transducer and activator of transcription 3 activation","volume":"56","author":"Brands","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2018.05.072_bb0040","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1161\/ATVBAHA.107.153080","article-title":"Il-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy","volume":"27","author":"Schrader","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0045","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist","volume":"16","author":"Dinarello","year":"1998","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0050","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1056\/NEJM200009073431011","article-title":"The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1","volume":"343","author":"Dinarello","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0055","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/0003319715583205","article-title":"Reducing vascular calcification by anti-IL-1\u03b2 monoclonal antibody in a mouse model of familial hypercholesterolemia","volume":"67","author":"Awan","year":"2016","journal-title":"Angiology"},{"key":"10.1016\/j.ijcard.2018.05.072_bb0060","first-page":"515","article-title":"Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA\/1 mice and prevents the associated acute-phase response","volume":"11","author":"Geiger","year":"1993","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0065","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/eurheartj\/ehr138","article-title":"Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition","volume":"33","author":"Virdis","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0070","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1191\/1358863x02vm413ra","article-title":"Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease","volume":"7","author":"Manning","year":"2002","journal-title":"Vasc. Med."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0075","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.ATV.0000214999.12921.4f","article-title":"Inflammation and cellular immune responses in abdominal aortic aneurysms","volume":"26","author":"Shimizu","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0080","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1161\/ATVBAHA.115.305269","article-title":"Inflammatory cell phenotypes in AAAs","volume":"35","author":"Dale","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0085","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1161\/01.ATV.17.11.2843","article-title":"Elevated circulating levels of inflammatory cytokines in patients with abdominal aortic aneurysm","volume":"17","author":"Juvonen","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0090","doi-asserted-by":"crossref","first-page":"441","DOI":"10.5551\/jat.31997","article-title":"A dipeptidyl peptidase-4 inhibitor but not incretins suppreses abdominal aortic aneurysms in angiotensin II-infused apolipoprotein E-null mice","volume":"23","author":"Kohashi","year":"2016","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0095","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1161\/ATVBAHA.114.303086","article-title":"NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice","volume":"34","author":"Kigawa","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0100","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1038\/ncomms8464","article-title":"IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)V\u03b36(+)\u03b3\u03b4 T cells","volume":"6","author":"Akitsu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0105","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1056\/NEJMoa0810787","article-title":"Use of canakinumab in the cryopyrin-associated periodic syndrome","volume":"360","author":"Lachmann","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0110","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2018.05.072_bb0115","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1161\/CIRCULATIONAHA.112.122556","article-title":"Effects of interleukin-1beta inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial","volume":"126","author":"Ridker","year":"2012","journal-title":"Circulation"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731832833X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731832833X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T05:43:47Z","timestamp":1536731027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016752731832833X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":23,"alternative-id":["S016752731832833X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.05.072","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.05.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}