{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:54:35Z","timestamp":1770540875773,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008436","name":"Ernst und Berta Grimmke Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 03Z2CN11"],"award-info":[{"award-number":["FKZ 03Z2CN11"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 03Z2CN12"],"award-info":[{"award-number":["FKZ 03Z2CN12"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","award":["F\/01\/10"],"award-info":[{"award-number":["F\/01\/10"]}],"id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ijcard.2018.06.025","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T03:19:43Z","timestamp":1528859983000},"page":"278-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["MD-2 is a new predictive biomarker in dilated cardiomyopathy and exerts direct effects in isolated cardiomyocytes"],"prefix":"10.1016","volume":"270","author":[{"given":"Alexander","family":"Riad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannine","family":"Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rico","family":"Feldtmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina B.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Reinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Weitmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Empen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Beug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"D\u00f6rr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan B.","family":"Felix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ijcard.2018.06.025_bb0005","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jacc.2011.05.033","article-title":"Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy results of the IMAC (intervention in myocarditis and acute cardiomyopathy)-2 study","volume":"58","author":"McNamara","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"issue":"20","key":"10.1016\/j.ijcard.2018.06.025_bb0010","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1056\/NEJMra0800239","article-title":"Biomarkers in heart failure","volume":"358","author":"Braunwald","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.ijcard.2018.06.025_bb0015","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/j.ijcard.2013.01.157","article-title":"Heart failure biomarkers in patients with dilated cardiomyopathy","volume":"168","author":"Bielecka-Dabrowa","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2018.06.025_bb0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","article-title":"Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy","volume":"61","author":"Kubanek","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.ijcard.2018.06.025_bb0025","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.ijcard.2012.11.061","article-title":"Initial white blood cell count is an independent risk factor for survival in patients with dilated cardiomyopathy","volume":"168","author":"Riad","year":"2012","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2018.06.025_bb0030","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/CIRCULATIONAHA.112.120485","article-title":"Are serial BNP measurements useful in heart failure management? Serial natriuretic peptide measurements are useful in heart failure management","volume":"127","author":"Januzzi","year":"2013","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.ijcard.2018.06.025_bb0035","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"Mcmurray","year":"2012","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.ijcard.2018.06.025_bb0040","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ehj.2003.10.030","article-title":"The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT","volume":"25","author":"Latini","year":"2004","journal-title":"Eur. Heart J."},{"issue":"7492","key":"10.1016\/j.ijcard.2018.06.025_bb0045","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/bmj.330.7492.625","article-title":"How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review","volume":"330","author":"Doust","year":"2005","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.ijcard.2018.06.025_bb0050","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pcad.2011.03.003","article-title":"Establishing prognosis in heart failure: a multimarker approach","volume":"54","author":"Ketchum","year":"2011","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"6","key":"10.1016\/j.ijcard.2018.06.025_bb0055","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.jacc.2004.06.015","article-title":"Primary results of the rapid emergency department heart failure outpatient trial (REDHOT). A multicenter study of B-type natriuretic peptide levels, emergency department decision making, and outcomes in patients presenting with shortness of breath","volume":"44","author":"Maisel","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2018.06.025_bb0060","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ejheart.2004.12.006","article-title":"Pre-discharge B-type natriuretic peptide predicts early recurrence of decompensated heart failure in patients admitted to a general medical unit","volume":"7","author":"Verdiani","year":"2005","journal-title":"Eur. J. Heart Fail."},{"issue":"5","key":"10.1016\/j.ijcard.2018.06.025_bb0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijmm.2007.04.001","article-title":"Structural biology of the LPS recognition","volume":"297","author":"Jerala","year":"2007","journal-title":"Int. J. Med. Microbiol."},{"issue":"27","key":"10.1016\/j.ijcard.2018.06.025_bb0070","doi-asserted-by":"crossref","first-page":"20861","DOI":"10.1074\/jbc.M002896200","article-title":"Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1","volume":"275","author":"Yang","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.ijcard.2018.06.025_bb0075","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ni809","article-title":"Essential role of MD-2 in LPS responsiveness and TLR4 distribution","volume":"3","author":"Nagai","year":"2002","journal-title":"Nat. Immunol."},{"issue":"32","key":"10.1016\/j.ijcard.2018.06.025_bb0080","doi-asserted-by":"crossref","first-page":"27236","DOI":"10.1074\/jbc.M112.369728","article-title":"Variants of toll-like receptor 4 predict cardiac recovery in patients with dilated cardiomyopathy","volume":"287","author":"Riad","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.ijcard.2018.06.025_bb0085","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1161\/01.CIR.95.6.1686","volume":"95","author":"Cheitlin","year":"1997","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcard.2018.06.025_bb0090","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1161\/CIRCULATIONAHA.108.769489","article-title":"Predictors of outcome in patients with suspected myocarditis","volume":"118","author":"Kindermann","year":"2008","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.ijcard.2018.06.025_bb0095","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcard.2018.06.025_bb0100","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ahj.2008.02.015","article-title":"Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy","volume":"156","author":"Landsberger","year":"2008","journal-title":"Am. Heart J."},{"issue":"3","key":"10.1016\/j.ijcard.2018.06.025_bb0105","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00395-011-0151-6","article-title":"Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes","volume":"106","author":"Grube","year":"2011","journal-title":"Basic Res. Cardiol."},{"issue":"6","key":"10.1016\/j.ijcard.2018.06.025_bb0110","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cardfail.2008.02.016","article-title":"Recent insights into the role of autoimmunity in idiopathic dilated cardiomyopathy","volume":"14","author":"Lappe","year":"2008","journal-title":"J. Card. Fail."},{"issue":"12","key":"10.1016\/j.ijcard.2018.06.025_bb0115","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.amjcard.2005.07.093","article-title":"Inflammatory markers and serum lipids in idiopathic dilated cardiomyopathy","volume":"96","author":"Sampietro","year":"2005","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2018.06.025_bb0120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejheart.2006.04.001","article-title":"Prognostic role of myocardial tumor necrosis factor-alpha and terminal complement complex expression in patients with dilated cardiomyopathy","volume":"9","author":"Zimmermann","year":"2007","journal-title":"Eur. J. Heart Fail."},{"issue":"7242","key":"10.1016\/j.ijcard.2018.06.025_bb0125","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nature07830","article-title":"The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex","volume":"458","author":"Park","year":"2009","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ijcard.2018.06.025_bb0130","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.ijcard.2018.06.025_bb0135","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejheart.2008.01.004","article-title":"Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice","volume":"10","author":"Riad","year":"2008","journal-title":"Eur. J. Heart Fail."},{"issue":"10","key":"10.1016\/j.ijcard.2018.06.025_bb0140","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.4049\/jimmunol.180.10.6954","article-title":"Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice","volume":"180","author":"Riad","year":"2008","journal-title":"J. Immunol."},{"issue":"15","key":"10.1016\/j.ijcard.2018.06.025_bb0145","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1161\/CIRCULATIONAHA.105.536433","article-title":"Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production","volume":"112","author":"Fuse","year":"2005","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcard.2018.06.025_bb0150","doi-asserted-by":"crossref","first-page":"H2024","DOI":"10.1152\/ajpheart.01188.2009","article-title":"Myeloid differentiation factor-88 contributes to TLR9-mediated modulation of acute coxsackievirus B3-induced myocarditis in vivo","volume":"298","author":"Riad","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"21","key":"10.1016\/j.ijcard.2018.06.025_bb0155","doi-asserted-by":"crossref","first-page":"12156","DOI":"10.1073\/pnas.211445098","article-title":"Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to toll-like receptor 4","volume":"98","author":"Visintin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.ijcard.2018.06.025_bb0160","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.189.11.1777","article-title":"MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4","volume":"189","author":"Shimazu","year":"1999","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.ijcard.2018.06.025_bb0165","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.imlet.2011.07.010","article-title":"Myeloid differentiation protein 2 silencing decreases LPS-induced cytokine production and TLR4\/MyD88 pathway activity in alveolar macrophages","volume":"141","author":"Ren","year":"2011","journal-title":"Immunol. Lett."},{"issue":"6","key":"10.1016\/j.ijcard.2018.06.025_bb0170","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1189\/jlb.1209775","article-title":"Endogenous ligands of TLR2 and TLR4: agonists or assistants?","volume":"87","author":"Erridge","year":"2010","journal-title":"J. Leukoc. Biol."},{"issue":"7061","key":"10.1016\/j.ijcard.2018.06.025_bb0175","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03985","article-title":"A network-based analysis of systemic inflammation in humans","volume":"437","author":"Calvano","year":"2005","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ijcard.2018.06.025_bb0180","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1073\/pnas.0306906101","article-title":"Isolation of an endotoxin-MD-2 complex that produces toll-like receptor 4-dependent cell activation at picomolar concentrations","volume":"101","author":"Gioannini","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.ijcard.2018.06.025_bb0185","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1182\/blood-2003-04-1290","article-title":"Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock","volume":"104","author":"Pugin","year":"2004","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.ijcard.2018.06.025_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050071","article-title":"MAPK signaling drives inflammation in LPS-stimulated cardiomyocytes: the route of crosstalk to G-protein-coupled receptors","volume":"7","author":"Frazier","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ijcard.2018.06.025_bb0195","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMoa020233","article-title":"Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure","volume":"347","author":"Maisel","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"9380","key":"10.1016\/j.ijcard.2018.06.025_bb0200","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0140-6736(03)13976-1","article-title":"B-type natriuretic peptide in cardiovascular disease","volume":"362","author":"De Lemos","year":"2003","journal-title":"Lancet"},{"issue":"9210","key":"10.1016\/j.ijcard.2018.06.025_bb0205","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(00)02060-2","article-title":"Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations","volume":"355","author":"Troughton","year":"2000","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ijcard.2018.06.025_bb0210","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1081\/STA-200026579","article-title":"Inference on correlated discrimination measures in survival analysis: a nonparametric approach","volume":"33","author":"Antolini","year":"2004","journal-title":"Commun. Stat. Theory Methods"},{"issue":"3","key":"10.1016\/j.ijcard.2018.06.025_bb0215","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/1536867X1001000303","article-title":"Comparing the predictive powers of survival models using Harrell's C or Somers' D","volume":"10","author":"Newson","year":"2010","journal-title":"Stata J."},{"key":"10.1016\/j.ijcard.2018.06.025_bb0220","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/aje\/kwk052","article-title":"Relaxing the rule of ten events per variable in logistic and cox regression","volume":"165","author":"Vittinghoff","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ijcard.2018.06.025_bb0225","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/CIRCULATIONAHA.107.186093","article-title":"The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology","volume":"116","author":"Cooper","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.06.025_bb0230","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0046-8177(87)80363-5","article-title":"Myocarditis: the Dallas criteria","volume":"18","author":"Aretz","year":"1987","journal-title":"Hum. Pathol."},{"issue":"4","key":"10.1016\/j.ijcard.2018.06.025_bb0235","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat. Med."},{"issue":"3","key":"10.1016\/j.ijcard.2018.06.025_bb0240","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/aje\/kwu140","article-title":"Correcting for optimistic prediction in small data sets","volume":"180","author":"Smith","year":"2014","journal-title":"Am. J. Epidemiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318314074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318314074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:38:30Z","timestamp":1759091910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318314074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":48,"alternative-id":["S0167527318314074"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.06.025","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MD-2 is a new predictive biomarker in dilated cardiomyopathy and exerts direct effects in isolated cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}