{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:14:08Z","timestamp":1776327248654,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530017"],"award-info":[{"award-number":["81530017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81521061"],"award-info":[{"award-number":["81521061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770397"],"award-info":[{"award-number":["81770397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670360"],"award-info":[{"award-number":["81670360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500252"],"award-info":[{"award-number":["81500252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770267"],"award-info":[{"award-number":["81770267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["1500219135"],"award-info":[{"award-number":["1500219135"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["1507219086"],"award-info":[{"award-number":["1507219086"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010032","name":"Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["2017YQ045"],"award-info":[{"award-number":["2017YQ045"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ijcard.2018.06.029","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T20:46:55Z","timestamp":1528404415000},"page":"120-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel"],"prefix":"10.1016","volume":"275","author":[{"given":"Dandan","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duanyang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.06.029_bb0005","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and beta-catenin signalling: diseases and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0020","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35035124","article-title":"An LDL-receptor-related protein mediates Wnt signalling in mice","volume":"407","author":"Pinson","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tem.2012.10.003","article-title":"LRP5 and LRP6 in development and disease","volume":"24","author":"Joiner","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0030","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/CIRCULATIONAHA.116.024441","article-title":"Opposing roles of Wnt inhibitors IGFBP-4 and Dkk1 in cardiac ischemia by differential targeting of LRP5\/6 and \u03b2-catenin","volume":"134","author":"Wo","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0035","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1091\/mbc.e08-07-0711","article-title":"The extracellular domain of Lrp5\/6 inhibits noncanonical Wnt signaling in vivo","volume":"20","author":"Bryja","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0040","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","article-title":"LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development","volume":"107","author":"Gong","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0045","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1002\/jcb.23182","article-title":"The role of Lrp5\/6 in cardiac valve disease: LDL-density-pressure theory","volume":"112","author":"Rajamannan","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0050","article-title":"LRP6 acts as a scaffold protein in cardiac gap junction assembly","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/415213a","article-title":"Cardiac channelopathies","volume":"415","author":"Marb\u00e1n","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0060","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature10761","article-title":"The promise of induced pluripotent stem cells in research and therapy","volume":"481","author":"Daisy","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0065","first-page":"H747","article-title":"Measurement of heart rate and QT interval in the conscious mouse","volume":"274","author":"Mitchell","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0070","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature15372","article-title":"Epicardial FSTL1 reconstitution regenerates the adult mammalian heart","volume":"525","author":"Wei","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0075","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1161\/CIRCRESAHA.116.306287","article-title":"Cold-inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels","volume":"116","author":"Li","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0080","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1152\/physrev.00002.2005","article-title":"Molecular physiology of cardiac repolarization","volume":"85","author":"Nerbonne","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0085","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/physrev.00022.2013","article-title":"Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia","volume":"94","author":"Schmitt","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0090","doi-asserted-by":"crossref","first-page":"E4288","DOI":"10.1073\/pnas.1617205114","article-title":"Exclusion of alternative exon 33 of Cav1.2 calcium channels in heart is proarrhythmogenic","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0095","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1253\/circj.69.1405","article-title":"Subtype switching of L-type Ca2+ channel from Cav1.3 to Cav1.2 in embryonic murine ventricle","volume":"69","author":"Takemura","year":"2005","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0100","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007880","article-title":"Frizzled and LRP5\/6 receptors for Wnt\/\u03b2-catenin signaling","volume":"4","author":"MacDonald","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0105","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cell.2012.05.002","article-title":"Wnt signaling through inhibition of \u03b2-catenin degradation in an intact Axin1 complex","volume":"149","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nn.2712","article-title":"The Cav\u03b2 subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels","volume":"14","author":"Altier","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1073\/pnas.0133792100","article-title":"Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion","volume":"100","author":"Fujino","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0120","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/CIRCULATIONAHA.106.668392","article-title":"Loss-off function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST segment elevation, short QT intervals, and sudden cardiac death","volume":"115","author":"Antzelevitch","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.06.029_bb0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1161\/CIRCEP.109.921056","article-title":"Short QT syndrome: from bench to bedside","volume":"3","author":"Patel","year":"2010","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0130","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.cellbio.21.012704.133250","article-title":"Endoplasmic reticulum-associated degradation","volume":"21","author":"R\u00f6misch","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.physiol.67.040403.114521","article-title":"Intracellular calcium release and cardiac disease","volume":"67","author":"Wehrens","year":"2005","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0140","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1172\/JCI31060","article-title":"Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure","volume":"117","author":"Nakayama","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0145","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/physrev.00016.2013","article-title":"L-type Cav1.2 calcium channels: fromin vitro findings to in vivo function","volume":"94","author":"Hofmann","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0150","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0008-6363(97)00273-3","article-title":"Ca2+ currents in compensated hypertrophy and heart failure","volume":"37","author":"Richard","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0155","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/01.RES.0000033988.13062.7C","article-title":"L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices","volume":"91","author":"Chen","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.06.029_bb0160","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1172\/JCI58227","article-title":"Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice","volume":"122","author":"Goonasekera","year":"2012","journal-title":"J. Clin. Invest."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317361922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527317361922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T13:12:58Z","timestamp":1589893978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527317361922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":32,"alternative-id":["S0167527317361922"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.06.029","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.06.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}