{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:30:07Z","timestamp":1773660607290,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-HL007567"],"award-info":[{"award-number":["T32-HL007567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL-114770"],"award-info":[{"award-number":["R01-HL-114770"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-GM007250"],"award-info":[{"award-number":["T32-GM007250"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10-OD012635"],"award-info":[{"award-number":["S10-OD012635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["16POST30730000"],"award-info":[{"award-number":["16POST30730000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ijcard.2018.09.073","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T14:24:15Z","timestamp":1537539855000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9271-3988","authenticated-orcid":false,"given":"Jiayang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S.","family":"Gresham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranganath","family":"Mamidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-4832","authenticated-orcid":false,"given":"Chang Yoon","family":"Doh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Deschenes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian E.","family":"Stelzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.09.073_bb0005","first-page":"20","article-title":"Genetics and genomics of dilated cardiomyopathy and systolic heart failure","volume":"9","author":"Tayal","year":"2017","journal-title":"Gend. Med."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI62862","article-title":"Genetic mutations and mechanisms in dilated cardiomyopathy","volume":"123","author":"Mcnally","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0015","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1126\/science.aaa5458","article-title":"Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy","volume":"349","author":"Hinson","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0020","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.jacc.2016.08.079","article-title":"Clinical and mechanistic insights into the genetics of cardiomyopathy","volume":"68","author":"Burke","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(00)81878-4","article-title":"MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure","volume":"88","author":"Arber","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0030","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1093\/hmg\/ddn160","article-title":"Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy","volume":"17","author":"Geier","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0035","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1096-7192(03)00142-2","article-title":"Mutations in the muscle LIM protein and \u03b1-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis","volume":"80","author":"Mohapatra","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0040","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ymgme.2005.10.008","article-title":"Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin","volume":"88","author":"Bos","year":"2006","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0045","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/eurjhf\/hfs020","article-title":"Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP)","volume":"14","author":"Unsld","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0050","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/jcs.113.9.1553","article-title":"The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin","volume":"113","author":"Flick","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0055","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.bpj.2014.02.011","article-title":"Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases","volume":"106","author":"Spudich","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0060","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/CIRCRESAHA.110.223842","article-title":"Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor","volume":"111","author":"Moore","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1540-8167.2007.00965.x","article-title":"Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics","volume":"19","author":"Alcalai","year":"2008","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0070","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.cell.2016.04.002","article-title":"A tension-based model distinguishes hypertrophic versus dilated cardiomyopathy","volume":"165","author":"Davis","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0075","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/CIRCULATIONAHA.111.089219","article-title":"Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice","volume":"126","author":"Chen","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0080","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(11)61219-1","article-title":"Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study","volume":"378","author":"Teerlink","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0085","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1038\/ncomms6515","article-title":"Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice","volume":"5","author":"Mearini","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0090","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1200113","article-title":"Cardiac myosin activation: a potential therapeutic approach for systolic heart failure","volume":"331","author":"Malik","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0095","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1152\/physrev.00039.2007","article-title":"Designing heart performance by gene transfer","volume":"88","author":"Davis","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11886-017-0899-x","article-title":"Pharmacologic management for heart failure and emerging therapies","volume":"19","author":"Kim","year":"2017","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0105","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.yjmcc.2015.06.011","article-title":"Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C","volume":"85","author":"Mamidi","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0110","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1161\/01.RES.0000219863.94390.ce","article-title":"Ablation of cardiac myosin-binding protein-C accelerates stretch activation in murine skinned myocardium","volume":"98","author":"Stelzer","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0115","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/CIRCRESAHA.108.177683","article-title":"Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function","volume":"103","author":"Tong","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0120","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.yjmcc.2012.07.012","article-title":"Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium","volume":"53","author":"Colson","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0125","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.RES.0000012222.70819.64","article-title":"Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice","volume":"90","author":"Harris","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0130","doi-asserted-by":"crossref","first-page":"H52","DOI":"10.1152\/ajpheart.00929.2012","article-title":"Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere","volume":"305","author":"Cheng","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0135","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/01.HYP.0000202594.82271.92","article-title":"Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy","volume":"47","author":"Kennedy","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0140","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1113\/jphysiol.2014.276022","article-title":"The contribution of cardiac myosin binding protein-c Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility","volume":"592","author":"Gresham","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0145","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1085\/jgp.201010467","article-title":"Model representation of the nonlinear step response in cardiac muscle","volume":"136","author":"Ford","year":"2010","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.yjmcc.2007.05.003","article-title":"Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure","volume":"43","author":"El-Armouche","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0155","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.yjmcc.2010.09.007","article-title":"Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle","volume":"49","author":"Copeland","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0160","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0092-8674(00)81662-1","article-title":"Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy","volume":"99","author":"Minamisawa","year":"1999","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.ijcard.2018.09.073_bb0165","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1602445","article-title":"Cardiac myosin binding protein-C Ser(302) phosphorylation regulates cardiac \u03b2-adrenergic reserve","author":"Mamidi","year":"2017","journal-title":"Sci. Adv."},{"issue":"94\u2013100","key":"10.1016\/j.ijcard.2018.09.073_bb0170","first-page":"267","article-title":"Erratum: Time to dp\/dt(max), a preload-independent index of contractility: Open-chest dog study","volume":"91","author":"Adler","year":"1996","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0175","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1152\/japplphysiol.00306.2016","article-title":"Sarcomeric protein modification during adrenergic stress enhances cross-bridge kinetics and cardiac output","volume":"122","author":"Gresham","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0180","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCIMAGING.114.002120","article-title":"Prognostic implications of the systolic to diastolic duration ratio in children with idiopathic or familial dilated cardiomyopathy","volume":"7","author":"Mondal","year":"2014","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0185","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.yjmcc.2010.09.010","article-title":"Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy","volume":"49","author":"Pe\u00f1a","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0190","doi-asserted-by":"crossref","first-page":"H3101","DOI":"10.1152\/ajpheart.2000.279.6.H3101","article-title":"Cellular and functional defects in a mouse model of heart failure","volume":"279","author":"Esposito","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0195","doi-asserted-by":"crossref","first-page":"H2665","DOI":"10.1152\/ajpheart.2001.280.6.H2665","article-title":"Effects of deletion of muscle LIM protein on myocyte function","volume":"280","author":"Su","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0200","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.yjmcc.2005.12.002","article-title":"Increased phospholamban phosphorylation limits the force-frequency response in the MLP\u2212\/\u2212mouse with heart failure","volume":"40","author":"Antoons","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12120","article-title":"MLP and CARP are linked to chronic PKC\u03b1 signalling in dilated cardiomyopathy","volume":"7","author":"Lange","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0210","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.yjmcc.2013.07.016","article-title":"Deletion of the \u03b22-adrenergic receptor prevents the development of cardiomyopathy in mice","volume":"63","author":"Fajardo","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0215","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.yjmcc.2009.10.012","article-title":"Calcineurin protects the heart in a murine model of dilated cardiomyopathy","volume":"48","author":"Heineke","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0220","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004257","article-title":"Dose-dependent effects of the myosin activator omecamtiv mecarbil on cross-bridge behavior and force generation in failing human myocardium","volume":"10","author":"Mamidi","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.04.077","article-title":"Muscle LIM protein: master regulator of cardiac and skeletal muscle functions","volume":"566","author":"Vafiadaki","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0230","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/CIRCRESAHA.116.300561","article-title":"Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium","volume":"116","author":"Moss","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0235","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/CIRCRESAHA.108.178996","article-title":"Protein kinase a-mediated phosphorylation of cmybp-c increases proximity of myosin heads to actin in resting myocardium","volume":"103","author":"Colson","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0240","first-page":"73","article-title":"A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation","volume":"22","author":"Hinken","year":"2007","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.ijcard.2018.09.073_bb0245","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10741-005-5249-1","article-title":"Thick filament proteins and performance in human heart failure","volume":"10","author":"Palmer","year":"2005","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ijcard.2018.09.073_bb0250","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jcmg.2008.08.003","article-title":"Diastolic abnormalities as the first feature of hypertrophic cardiomyopathy in Dutch myosin-binding protein C founder mutations","volume":"2","author":"Michels","year":"2009","journal-title":"JACC Cardiovasc. Imaging"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318335630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318335630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T16:16:56Z","timestamp":1720628216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318335630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":50,"alternative-id":["S0167527318335630"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.09.073","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.09.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}