{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:28:53Z","timestamp":1782322133864,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ijcard.2018.09.090","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T18:18:02Z","timestamp":1538072282000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Efficacy and safety of cryoballoon ablation in the elderly: A multicenter study"],"prefix":"10.1016","volume":"278","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-8097","authenticated-orcid":false,"given":"Christian-Hendrik","family":"Heeger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bellmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Eric","family":"Bohnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Wissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wohlmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rottner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sohns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Richard","family":"Tilz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibu","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Leme\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"L\u00fcker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arian","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Plenge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Goldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Kuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Metzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Metzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Steven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rillig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.ijcard.2018.09.090_bb0005","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","volume":"37","author":"Kirchhof","year":"2016","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.ijcard.2018.09.090_bb0010","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005250","article-title":"Ten-year clinical outcome after circumferential pulmonary vein isolation utilizing the Hamburg approach in patients with symptomatic drug-refractory paroxysmal atrial fibrillation","volume":"11","author":"Tilz","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"23","key":"10.1016\/j.ijcard.2018.09.090_bb0015","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1161\/CIRCULATIONAHA.110.946806","article-title":"Long-term results of catheter ablation in paroxysmal atrial fibrillation: lessons from a 5-year follow-up","volume":"122","author":"Ouyang","year":"2010","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.ijcard.2018.09.090_bb0020","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.jacc.2012.04.060","article-title":"Catheter ablation of long-standing persistent atrial fibrillation: 5-year outcomes of the Hamburg sequential ablation strategy","volume":"60","author":"Tilz","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.ijcard.2018.09.090_bb0025","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/CIRCEP.115.003007","article-title":"Once isolated, always isolated? Incidence and characteristics of pulmonary vein reconduction after second-generation cryoballoon-based pulmonary vein isolation","volume":"8","author":"Heeger","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"5","key":"10.1016\/j.ijcard.2018.09.090_bb0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/jce.12626","article-title":"Durability of pulmonary vein isolation with cryoballoon ablation: results from the Sustained PV Isolation with Arctic Front Advance (SUPIR) study","volume":"26","author":"Reddy","year":"2015","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"7","key":"10.1016\/j.ijcard.2018.09.090_bb0035","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1253\/circj.CJ-16-1334","article-title":"Three-year clinical outcome after 2nd-generation cryoballoon-based pulmonary vein isolation for the treatment of paroxysmal and persistent atrial fibrillation - a 2-center experience","volume":"81","author":"Heeger","year":"2017","journal-title":"Circ. J."},{"issue":"2","key":"10.1016\/j.ijcard.2018.09.090_bb0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/europace\/euv092","article-title":"One-year clinical outcome after pulmonary vein isolation in persistent atrial fibrillation using the second-generation 28\u202fmm cryoballoon: a retrospective analysis","volume":"18","author":"Lemes","year":"2016","journal-title":"Europace"},{"issue":"1","key":"10.1016\/j.ijcard.2018.09.090_bb0045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00392-015-0890-8","article-title":"Two-year outcome after pulmonary vein isolation using the second-generation 28-mm cryoballoon: lessons from the bonus freeze protocol","volume":"105","author":"Metzner","year":"2016","journal-title":"Clin. Res. Cardiol."},{"issue":"2","key":"10.1016\/j.ijcard.2018.09.090_bb0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/CIRCEP.114.001473","article-title":"One-year clinical outcome after pulmonary vein isolation using the second-generation 28-mm cryoballoon","volume":"7","author":"Metzner","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"5","key":"10.1016\/j.ijcard.2018.09.090_bb0055","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/jce.12082","article-title":"Improved procedural efficacy of pulmonary vein isolation using the novel second-generation cryoballoon","volume":"24","author":"Furnkranz","year":"2013","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"5","key":"10.1016\/j.ijcard.2018.09.090_bb0060","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/europace\/eut417","article-title":"Second-generation cryoballoon ablation for paroxysmal atrial fibrillation: 1-year follow-up","volume":"16","author":"Chierchia","year":"2014","journal-title":"Europace"},{"issue":"23","key":"10.1016\/j.ijcard.2018.09.090_bb0065","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa1602014","article-title":"Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation","volume":"374","author":"Kuck","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"38","key":"10.1016\/j.ijcard.2018.09.090_bb0070","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","article-title":"2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"37","author":"Kirchhof","year":"2016","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.ijcard.2018.09.090_bb0075","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/europace\/euv229","article-title":"Ablation of atrial fibrillation in patients \u226575\u202fyears: long-term clinical outcome and safety","volume":"18","author":"Metzner","year":"2016","journal-title":"Europace"},{"issue":"1","key":"10.1016\/j.ijcard.2018.09.090_bb0080","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jjcc.2016.07.020","article-title":"Clinical outcome of 2nd generation cryoballoon pulmonary vein isolation in patients over 75\u202fyears of age","volume":"69","author":"Pott","year":"2017","journal-title":"J. Cardiol."},{"issue":"11","key":"10.1016\/j.ijcard.2018.09.090_bb0085","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1093\/europace\/eux023","article-title":"Efficacy and safety of the second generation cryoballoon ablation for the treatment of paroxysmal atrial fibrillation in patients over 75\u202fyears: a comparison with a younger cohort","volume":"19","author":"Abugattas","year":"2017","journal-title":"Europace"},{"issue":"12","key":"10.1016\/j.ijcard.2018.09.090_bb0090","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/jce.12529","article-title":"Rationale and design of FIRE AND ICE: a multicenter randomized trial comparing efficacy and safety of pulmonary vein isolation using a cryoballoon versus radiofrequency ablation with 3D-reconstruction","volume":"25","author":"Furnkranz","year":"2014","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"8","key":"10.1016\/j.ijcard.2018.09.090_bb0095","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/europace\/euv024","article-title":"One-year clinical success of a \u2018no-bonus\u2019 freeze protocol using the second-generation 28 mm cryoballoon for pulmonary vein isolation","volume":"17","author":"Wissner","year":"2015","journal-title":"Europace"},{"issue":"6","key":"10.1016\/j.ijcard.2018.09.090_bb0100","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s00392-015-0944-y","article-title":"Short tip-big difference? First-in-man experience and procedural efficacy of pulmonary vein isolation using the third-generation cryoballoon","volume":"105","author":"Heeger","year":"2016","journal-title":"Clin. Res. Cardiol."},{"issue":"2","key":"10.1016\/j.ijcard.2018.09.090_bb0105","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.hrthm.2014.10.033","article-title":"Reduced incidence of esophageal lesions by luminal esophageal temperature-guided second-generation cryoballoon ablation","volume":"12","author":"Furnkranz","year":"2015","journal-title":"Heart Rhythm."},{"issue":"2","key":"10.1016\/j.ijcard.2018.09.090_bb0110","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/CIRCEP.115.002734","article-title":"Electromyographic monitoring for prevention of phrenic nerve palsy in second-generation cryoballoon procedures","volume":"8","author":"Franceschi","year":"2015","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"5","key":"10.1016\/j.ijcard.2018.09.090_bb0115","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/jce.12358","article-title":"The incidence of phrenic nerve injury during pulmonary vein isolation using the second-generation 28\u202fmm cryoballoon","volume":"25","author":"Metzner","year":"2014","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"10","key":"10.1016\/j.ijcard.2018.09.090_bb0120","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/europace\/euw233","article-title":"First insights into cryoballoon-based pulmonary vein isolation taking the individual time-to-isolation into account","volume":"19","author":"Reissmann","year":"2017","journal-title":"Europace"},{"issue":"10","key":"10.1016\/j.ijcard.2018.09.090_bb0125","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1016\/j.hrthm.2017.05.012","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"14","author":"Calkins","year":"2017","journal-title":"Heart Rhythm."},{"issue":"9","key":"10.1016\/j.ijcard.2018.09.090_bb0130","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/europace\/eux219","article-title":"Is less more? Impact of different ablation protocols on periprocedural complications in second-generation cryoballoon based pulmonary vein isolation","volume":"20","author":"Rottner","year":"2018","journal-title":"Europace"},{"issue":"18","key":"10.1016\/j.ijcard.2018.09.090_bb0135","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and risk factors in atrial fibrillation (ATRIA) study","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.ijcard.2018.09.090_bb0140","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1540-8167.2010.01995.x","article-title":"Prevalence and predictors of complications of radiofrequency catheter ablation for atrial fibrillation","volume":"22","author":"Baman","year":"2011","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"8","key":"10.1016\/j.ijcard.2018.09.090_bb0145","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1540-8167.2008.01124.x","article-title":"Efficacy, safety, and outcome of atrial fibrillation ablation in septuagenarians","volume":"19","author":"Corrado","year":"2008","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"3","key":"10.1016\/j.ijcard.2018.09.090_bb0150","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10840-010-9490-8","article-title":"Ablation of atrial fibrillation after the retirement age: considerations on safety and outcome","volume":"28","author":"Haegeli","year":"2010","journal-title":"J. Interv. Card. Electrophysiol."},{"issue":"2","key":"10.1016\/j.ijcard.2018.09.090_bb0155","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/europace\/euv010","article-title":"Clinical management of arrhythmias in elderly patients: results of the European Heart Rhythm Association survey","volume":"17","author":"Chen","year":"2015","journal-title":"Europace"},{"issue":"5","key":"10.1016\/j.ijcard.2018.09.090_bb0160","first-page":"772","article-title":"Cryoballoon ablation in the elderly: oneyear outcome and safety of the second-generation 28\u202fmm cryoballoon in patients over 75\u202fyears old","volume":"20","author":"Tscholl","year":"2018","journal-title":"EP Eur."},{"issue":"9","key":"10.1016\/j.ijcard.2018.09.090_bb0165","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.hrthm.2016.05.022","article-title":"Two years outcome in patients with persistent atrial fibrillation after pulmonary vein isolation using the second-generation 28-mm cryoballoon","volume":"13","author":"Tscholl","year":"2016","journal-title":"Heart Rhythm."},{"issue":"19","key":"10.1016\/j.ijcard.2018.09.090_bb0170","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.113.003862","article-title":"In-hospital complications associated with catheter ablation of atrial fibrillation in the United States between 2000 and 2010: analysis of 93\u202f801 procedures","volume":"128","author":"Deshmukh","year":"2013","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcard.2018.09.090_bb0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCEP.109.859116","article-title":"Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation","volume":"3","author":"Cappato","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"3","key":"10.1016\/j.ijcard.2018.09.090_bb0180","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005925","article-title":"Bronchial injury after atrial fibrillation ablation using the second-generation cryoballoon","volume":"11","author":"Bellmann","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"4","key":"10.1016\/j.ijcard.2018.09.090_bb0185","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/europace\/euu320","article-title":"Incidence and characteristics of phrenic nerve palsy following pulmonary vein isolation with the second-generation as compared with the first-generation cryoballoon in 360 consecutive patients","volume":"17","author":"Furnkranz","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2018.09.090_bb0190","series-title":"European Society of Cardiology Congress, Munich, Germany, August 26, 2018","article-title":"Catheter ablation vs antiarrhythmic drug therapy in atrial fibrillation - CABANA","author":"Poole","year":"2018"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318347727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318347727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T21:43:22Z","timestamp":1662155002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318347727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":38,"alternative-id":["S0167527318347727"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.09.090","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of cryoballoon ablation in the elderly: A multicenter study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.09.090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}