{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:37:43Z","timestamp":1782283063243,"version":"3.54.5"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Provincial and Ministry Joint Major Projects of National Health Commission of China","award":["WKJ-ZJ-1703"],"award-info":[{"award-number":["WKJ-ZJ-1703"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470384"],"award-info":[{"award-number":["81470384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670259"],"award-info":[{"award-number":["81670259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Provincial and Ministry Joint Major Projects of National Health Commission of China","award":["WKJ-ZJ-1703"],"award-info":[{"award-number":["WKJ-ZJ-1703"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470384"],"award-info":[{"award-number":["81470384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670259"],"award-info":[{"award-number":["81670259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ijcard.2018.11.125","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T16:47:45Z","timestamp":1543423665000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Emerging roles of proteoglycans in cardiac remodeling"],"prefix":"10.1016","volume":"278","author":[{"given":"Xiaoya","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.11.125_bb0005","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cardfail.2017.04.014","article-title":"ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines and the Heart Failure Society of America","volume":"23","author":"Yancy","year":"2017","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0010","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12265-013-9472-1","article-title":"Biomarkers of diastolic dysfunction and myocardial fibrosis: application to heart failure with a preserved ejection fraction","volume":"6","author":"Zile","year":"2013","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0020","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","article-title":"Cardiovascular remodelling in coronary artery disease and heart failure","volume":"383","author":"Heusch","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0025","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.bbagen.2005.12.022","article-title":"The role of O-linked and N-linked oligosaccharides on the structure-function of glycoprotein hormones: development of agonists and antagonists","volume":"1760","author":"Fares","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pharmthera.2018.06.003","article-title":"Glycosylation as new pharmacological strategies for diseases associated with excessive angiogenesis","volume":"191","author":"Bousseau","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2015.02.003","article-title":"Proteoglycan form and function: a comprehensive nomenclature of proteoglycans","volume":"42","author":"Iozzo","year":"2015","journal-title":"Matrix Biol. J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0040","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1242\/dev.113894","article-title":"Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling","volume":"142","author":"Strate","year":"2015","journal-title":"Development (Cambridge)"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0045","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.matbio.2006.07.003","article-title":"The role of syndecans in disease and wound healing","volume":"25","author":"Fears","year":"2006","journal-title":"Matrix Biol. J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1152\/physiolgenomics.00144.2002","article-title":"Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling","volume":"16","author":"Finsen","year":"2004","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0055","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1161\/CIRCULATIONAHA.106.644609","article-title":"Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction","volume":"115","author":"Vanhoutte","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0060","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.yjmcc.2012.04.014","article-title":"Syndecan-4 over-expression preserves cardiac function in a rat model of myocardial infarction","volume":"53","author":"Xie","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0065","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10753-012-9582-y","article-title":"Sdc1 overexpression inhibits the p38 MAPK pathway and lessens fibrotic ventricular remodeling in MI rats","volume":"36","author":"Lei","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0070","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/cvr\/cvr149","article-title":"Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling","volume":"92","author":"Echtermeyer","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0075","article-title":"Wearable vibroacoustic transthoracic stimulation (VATS) provides cardioprotection by syndecan-4 mechanosensor regulation of NFAT, JNK\/ERK in rats after myocardial infarction","volume":"136","author":"Uryash","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0080","first-page":"2240","article-title":"Modulation of angiotensin II-mediated signalling by heparan sulphate glycosaminoglycans","volume":"18","author":"Koppel","year":"2003","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transplant Assoc. Eur. Ren. Assoc."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/hq0102.100314","article-title":"Mechanical stress regulates syndecan-4 expression and redistribution in vascular smooth muscle cells","volume":"22","author":"Li","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0090","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1161\/CIRCRESAHA.110.235689","article-title":"Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction","volume":"108","author":"Matsui","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/HYPERTENSIONAHA.109.137885","article-title":"Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis","volume":"55","author":"Schellings","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/HYPERTENSIONAHA.109.147256","article-title":"Syndecan-1: a critical mediator in cardiac fibrosis","volume":"55","author":"Frangogiannis","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.matbio.2005.05.003","article-title":"A role for decorin in the remodeling of myocardial infarction","volume":"24","author":"Weis","year":"2005","journal-title":"Matrix Biol. J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0110","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCULATIONAHA.107.714147","article-title":"Biglycan is required for adaptive remodeling after myocardial infarction","volume":"117","author":"Westermann","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0115","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1253\/jcj.65.445","article-title":"Expression and localization of lumican in the ischemic and reperfused rat heart","volume":"65","author":"Baba","year":"2001","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0120","first-page":"6","article-title":"Mimecan is an essential regulator of cardiac extracellular matrix integrity after myocardial infarction","volume":"31","author":"Van Aelst","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0125","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/CIRCRESAHA.116.304599","article-title":"Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening","volume":"116","author":"Van Aelst","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0130","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1369\/0022155412456380","article-title":"Biglycan: a multivalent proteoglycan providing structure and signals","volume":"60","author":"Nastase","year":"2012","journal-title":"J. Histochem. Cytochem. Off. J. Histochem. Soc."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0135","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.matbio.2013.04.004","article-title":"Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels","volume":"32","author":"Reese","year":"2013","journal-title":"Matrix Biol. J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0140","doi-asserted-by":"crossref","first-page":"H1504","DOI":"10.1152\/ajpheart.00194.2009","article-title":"Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction","volume":"297","author":"Li","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0145","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1089\/hum.2008.204","article-title":"Decorin gene delivery inhibits cardiac fibrosis in spontaneously hypertensive rats by modulation of transforming growth factor-beta\/Smad and p38 mitogen-activated protein kinase signaling pathways","volume":"20","author":"Yan","year":"2009","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0150","first-page":"ii334","article-title":"Biglycan and decorin protect cardiomyocytes against hypoxia-reoxygenation injury by an NO-dependent mechanism","volume":"8","author":"Gorbe","year":"2009","journal-title":"Eur. J. Heart Fail. Suppl."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0155","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yjmcc.2016.08.006","article-title":"The cytoprotective effect of biglycan core protein involves toll-like receptor 4 signaling in cardiomyocytes","volume":"99","author":"Gaspar","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.matbio.2018.01.001","article-title":"Sweet, yet underappreciated: proteoglycans and extracellular matrix remodeling in heart disease","author":"Christensen","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0165","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1006\/jmcc.2000.1146","article-title":"Expression of perlecan proteoglycan in the infarct zone of mouse myocardial infarction","volume":"32","author":"Nakahama","year":"2000","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0170","first-page":"1857","article-title":"Perlecan participates in the protection of ischemic myocardium induced by basic fibroblast growth factor: experiment with rats","volume":"87","author":"Fu","year":"2007","journal-title":"Natl. Med. J. China"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0175","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein agrin promotes heart regeneration in mice","volume":"547","author":"Bassat","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0180","first-page":"132","article-title":"NG2+ cells protect against cardiac remodeling and failure after myocardial infarction in mice","author":"Offerhaus","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0185","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.4049\/jimmunol.180.4.2625","article-title":"CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response","volume":"180","author":"Huebener","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0190","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijcard.2015.03.054","article-title":"Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution","volume":"185","author":"Iyer","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0195","doi-asserted-by":"crossref","DOI":"10.1097\/SHK.0000000000001132","article-title":"CD44 deficiency in mice protects the heart against angiotensin II-induced cardiac fibrosis","author":"Yang","year":"2018","journal-title":"Shock (Augusta, GA)"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.lfs.2018.08.009","article-title":"The role of CD44, hyaluronan and NHE1 in cardiac remodeling","volume":"209","author":"Suleiman","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0205","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1253\/circj.CJ-09-0486","article-title":"Inhibition of endostatin\/collagen XVIII deteriorates left ventricular remodeling and heart failure in rat myocardial infarction model","volume":"74","author":"Isobe","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0210","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005357","article-title":"Transforming growth factor-beta receptor III is a potential regulator of ischemia-induced cardiomyocyte apoptosis","volume":"6","author":"Sun","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0215","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1111\/bph.13166","article-title":"Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-beta receptor III expression","volume":"172","author":"Sun","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"1 SUPPL","key":"10.1016\/j.ijcard.2018.11.125_bb0220","first-page":"1","article-title":"Adverse cardiac remodeling mediated by the altered expression of versican","volume":"28","author":"Mjaatvedt","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028302","article-title":"Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway","volume":"6","author":"Finsen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0230","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ar.10130","article-title":"Localization of the transmembrane proteoglycan syndecan-4 and its regulatory kinases in costameres of rat cardiomyocytes: a deconvolution microscopic study","volume":"268","author":"Vanwinkle","year":"2002","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0235","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/01.RES.0000116143.74830.A9","article-title":"At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function","volume":"94","author":"Pyle","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0240","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1111\/febs.12161","article-title":"Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart","volume":"280","author":"Strand","year":"2013","journal-title":"FEBS J."},{"issue":"Suppl","key":"10.1016\/j.ijcard.2018.11.125_bb0245","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","article-title":"NFAT signaling: choreographing the social lives of cells","volume":"109","author":"Crabtree","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0250","first-page":"124","article-title":"The Z-disc proteoglycan syndecan-4 regulates mechanical stress-induced calcineurin-NFAT signaling in cardiomyocytes","author":"Lunde","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0255","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.carpath.2017.03.008","article-title":"Syndecan-4 deficiency accelerates the transition from compensated hypertrophy to heart failure following pressure overload","volume":"28","author":"Li","year":"2017","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0260","first-page":"111","article-title":"Myocardial levels of the syndecan proteoglycan family are associated with inflammation, arrhythmogenesis and septal function in obstructive hypertrophic cardiomyopathy","volume":"16","author":"Lunde","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0265","first-page":"126","article-title":"The adhesion site transmembrane proteoglycan syndecan-4; an integrator of pro-hypertrophic and pro-inflammatory signaling in the heart?","author":"Strand","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0270","first-page":"213","article-title":"Syndecan-4 shedding is involved in the innate immune response of the heart to LPS challenge and pressure overload","volume":"16","author":"Strand","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0275","doi-asserted-by":"crossref","first-page":"22102","DOI":"10.1073\/pnas.0902639106","article-title":"Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches","volume":"106","author":"Bellin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0280","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/cvr\/cvv002","article-title":"Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart","volume":"106","author":"Herum","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0285","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yjmcc.2012.11.006","article-title":"Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress","volume":"54","author":"Herum","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0290","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/gye.43.1.32.43","article-title":"Ontogeny of enhanced decorin levels and distribution within myocardium of failing hearts","volume":"43","author":"Medeiros","year":"2002","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0295","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.healun.2006.10.005","article-title":"Decorin-mediated transforming growth factor-\u03b2 inhibition ameliorates adverse cardiac remodeling","volume":"26","author":"Jahanyar","year":"2007","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0300","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.yjmcc.2015.04.007","article-title":"Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly","volume":"84","author":"Dupuis","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0305","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.bbrc.2016.12.033","article-title":"Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis","volume":"482","author":"Chen","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0310","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/eurheartj\/ehx493.5924","article-title":"Lack of the extracellular matrix proteoglycan lumican in mice exacerbates left ventricular dilatation and contractile dysfunction upon pressure overload","volume":"38","author":"Mohammadzadeh","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0315","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1111\/febs.12235","article-title":"Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli","volume":"280","author":"Engebretsen","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0320","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ng.134","article-title":"Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass","volume":"40","author":"Petretto","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0325","first-page":"342","article-title":"Osteoglycin deficiency leads to maladaptive remodeling and severe cardiac dysfunction in a mouse model of cardiac hypertrophy","volume":"33","author":"Voss","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0330","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.matbio.2017.09.002","article-title":"Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation","volume":"66","author":"Deckx","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0335","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1074\/jbc.M109.033787","article-title":"Recombinant human collagen XV regulates cell adhesion and migration","volume":"285","author":"Hurskainen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0340","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/CIRCRESAHA.110.222133","article-title":"Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy","volume":"107","author":"Rasi","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0345","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/HYPERTENSIONAHA.116.07420","article-title":"Type III transforming growth factor-beta receptor drives cardiac hypertrophy through beta-arrestin2-dependent activation of calmodulin-dependent protein kinase II","volume":"68","author":"Lou","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165079","article-title":"The heparan sulfate proteoglycan glypican-6 is upregulated in the failing heart, and regulates cardiomyocyte growth through ERK1\/2 signaling","volume":"11","author":"Melleby","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0355","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.yjmcc.2016.10.011","article-title":"Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload","volume":"101","author":"Beetz","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201422","article-title":"The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling","volume":"13","author":"Andenaes","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0365","doi-asserted-by":"crossref","DOI":"10.1161\/circ.128.suppl_22.A18184","article-title":"Deficiency in the novel small leucin-rich repeat protein podocan promotes pressure load-induced cardiac hypertrophy","volume":"128","author":"Speidl","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0370","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/eurheartj\/eht309.P4205","article-title":"Biglcan is beneficial in angiotensin II induced heart failure by preventing cardiac inflammation and remodeling improving LV function and mortality by preventing transdifferentiation of myofibroblasts","volume":"34","author":"Westermann","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0375","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jacc.2011.10.888","article-title":"Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction","volume":"59","author":"Singelyn","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0380","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2015.06.002","article-title":"Decellularized myocardial matrix hydrogels: in basic research and preclinical studies","volume":"96","author":"Wang","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089621","article-title":"Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding","volume":"9","author":"Vistnes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2018.11.125_bb0390","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1292\/jvms.15-0274","article-title":"Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats","volume":"78","author":"Ishiguro-Oonuma","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.ijcard.2018.11.125_bb0395","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/CIRCULATIONAHA.117.030353","article-title":"Targeting chondroitin sulfate glycosaminoglycans to treat cardiac fibrosis in pathological remodeling","volume":"137","author":"Zhao","year":"2018","journal-title":"Circulation"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318359151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318359151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T20:59:52Z","timestamp":1720817992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318359151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":79,"alternative-id":["S0167527318359151"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.11.125","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging roles of proteoglycans in cardiac remodeling","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.11.125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}