{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:18:46Z","timestamp":1785367126390,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ijcard.2018.12.066","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T12:32:47Z","timestamp":1545913967000},"page":"79-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center"],"prefix":"10.1016","volume":"279","author":[{"given":"Christine","family":"Rootwelt-Norberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind H.","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars A.","family":"Dejgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Chivulescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida S.","family":"Leren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Edvardsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina H.","family":"Haugaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2018.12.066_bb0005","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/europace\/euv340","article-title":"Arrhythmogenic right ventricular cardiomyopathy, clinical manifestations, and diagnosis","volume":"18","author":"Haugaa","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2018.12.066_bb0010","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/CIRCGENETICS.114.001003","article-title":"Clinical presentation, long-term follow-up, and outcomes of 1001 arrhythmogenic right ventricular dysplasia\/cardiomyopathy patients and family members","volume":"8","author":"Groeneweg","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0015","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/CIRCULATIONAHA.110.988287","article-title":"Arrhythmogenic right ventricular dysplasia\/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia\/cardiomyopathy genotype-phenotype follow-up study","volume":"123","author":"Cox","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.12.066_bb0020","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1161\/01.CIR.0000143375.93288.82","article-title":"Natural history and risk stratification of arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"110","author":"Hulot","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.12.066_bb0025","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/eurheartj\/ehu509","article-title":"Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated mutation carriers","volume":"36","author":"Bhonsale","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra1509267","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"376","author":"Corrado","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0035","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1161\/CIRCULATIONAHA.105.542266","article-title":"Arrhythmogenic right ventricular dysplasia: a United States experience","volume":"112","author":"Dalal","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2018.12.066_bb0040","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.jacc.2016.09.951","article-title":"Arrhythmogenic right ventricular cardiomyopathy: clinical course and predictors of arrhythmic risk","volume":"68","author":"Mazzanti","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0045","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/CIRCEP.113.000233","article-title":"Risk stratification in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated desmosomal mutation carriers","volume":"6","author":"Bhonsale","year":"2013","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0050","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0140-6736(09)60256-7","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"373","author":"Basso","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2018.12.066_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJM198801213180301","article-title":"Right ventricular cardiomyopathy and sudden death in young people","volume":"318","author":"Thiene","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0060","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/S0735-1097(97)00332-X","article-title":"Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: a multicenter study","volume":"30","author":"Corrado","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the Task Force Criteria","volume":"31","author":"Marcus","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0070","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/ehjci\/jew229","article-title":"Comprehensive multi-modality imaging approach in arrhythmogenic cardiomyopathy-an expert consensus document of the European Association of Cardiovascular Imaging","volume":"18","author":"Haugaa","year":"2017","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2018.12.066_bb0075","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1016\/j.hrthm.2014.07.024","article-title":"EHRA\/HRS\/APHRS expert consensus on ventricular arrhythmias","volume":"11","author":"Pedersen","year":"2014","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0080","first-page":"2631","article-title":"Guidelines for the diagnosis and management of syncope","volume":"30","author":"Moya","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0085","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/ejhf.181","article-title":"Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members","volume":"16","author":"Saberniak","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0090","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jcmg.2016.06.011","article-title":"Combination of ECG and echocardiography for identification of arrhythmic events in early ARVC","volume":"10","author":"Leren","year":"2017","journal-title":"J. Am. Coll. Cardiol. Img."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0095","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.jacc.2007.08.008","article-title":"Role of genetic analysis in the management of patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"50","author":"Sen-Chowdhry","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.amjcard.2017.03.251","article-title":"Comparison of features of fatal versus nonfatal cardiac arrest in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"120","author":"Gupta","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0105","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCGENETICS.113.000288","article-title":"Compound and digenic heterozygosity predicts lifetime arrhythmic outcome and sudden cardiac death in desmosomal gene-related arrhythmogenic right ventricular cardiomyopathy","volume":"6","author":"Rigato","year":"2013","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0110","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.amjcard.2008.06.054","article-title":"Comparison of clinical features of arrhythmogenic right ventricular cardiomyopathy in men versus women","volume":"102","author":"Bauce","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2018.12.066_bb0115","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/S0735-1097(00)00997-9","article-title":"Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy","volume":"36","author":"Nava","year":"2000","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318353968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318353968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T01:42:01Z","timestamp":1565228521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318353968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":23,"alternative-id":["S0167527318353968"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.12.066","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2018.12.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}