{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:31:44Z","timestamp":1768008704172,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008728","name":"Japan Research Foundation for Clinical Pharmacology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008728","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Cardiovascular Research Foundation","award":["29-4-3"],"award-info":[{"award-number":["29-4-3"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ijcard.2019.01.049","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T11:18:18Z","timestamp":1547551098000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Effect of intravenous carperitide versus nitrates as first-line vasodilators on in-hospital outcomes in hospitalized patients with acute heart failure: Insight from a nationwide claim-based database"],"prefix":"10.1016","volume":"280","author":[{"given":"Toshiyuki","family":"Nagai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotsugu","family":"Iwakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michikazu","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Sumita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2016","key":"10.1016\/j.ijcard.2019.01.049_bb0005","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"2013","key":"10.1016\/j.ijcard.2019.01.049_bb0010","first-page":"e240","article-title":"ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"128","author":"Writing Committee M","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.01.049_bb0015","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1056\/NEJMoa1601895","article-title":"Effect of ularitide on cardiovascular mortality in acute heart failure","volume":"376","author":"Packer","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0020","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/ejhf.830","article-title":"Serelaxin in addition to standard therapy in acute heart failure: rationale and design of the RELAX-AHF-2 study","volume":"19","author":"Teerlink","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(12)61855-8","article-title":"Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial","volume":"381","author":"Teerlink","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2019.01.049_bb0030","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa1100171","article-title":"Effect of nesiritide in patients with acute decompensated heart failure","volume":"365","author":"O'Connor","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/313397a0","article-title":"Structural identification of beta- and gamma-human atrial natriuretic polypeptides","volume":"313","author":"Kangawa","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2019.01.049_bb0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0006-291X(84)91077-5","article-title":"Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP)","volume":"118","author":"Kangawa","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0045","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1253\/circj.CJ-08-0130","article-title":"Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure: the PROTECT multicenter randomized controlled study","volume":"72","author":"Hata","year":"2008","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0050","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cardfail.2015.05.007","article-title":"Carperitide is associated with increased in-hospital mortality in acute heart failure: a propensity score-matched analysis","volume":"21","author":"Matsue","year":"2015","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0055","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijcard.2017.04.078","article-title":"The impact of carperitide usage on the cost of hospitalization and outcome in patients with acute heart failure: high value care vs. low value care campaign in Japan","volume":"241","author":"Mizuno","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0060","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1253\/circj.CJ-13-0187","article-title":"Clinical features and outcome in hospitalized heart failure in Japan (from the ATTEND Registry)","volume":"77","author":"Sato","year":"2013","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0065","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1253\/circj.CJ-66-0068","article-title":"Guidelines for treatment of acute heart failure (JCS 2011)","volume":"77","author":"JCS Joint Working Group","year":"2013","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0070","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1253\/circj.CJ-16-0196","article-title":"The current status of cardiovascular medicine in Japan-analysis of a large number of health records from a nationwide claim-based database, JROAD-DPC","volume":"80","author":"Yasuda","year":"2016","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0075","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/j.jacc.2017.03.578","article-title":"beta-Blockers and mortality after acute myocardial infarction in patients without heart failure or ventricular dysfunction","volume":"69","author":"Dondo","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0080","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cjca.2012.11.021","article-title":"Development and validation of an acute heart failure-specific mortality predictive model based on administrative data","volume":"29","author":"Sasaki","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/01.CIR.83.1.191","article-title":"Mechanisms involved in the response to prolonged infusion of atrial natriuretic factor in patients with chronic heart failure","volume":"83","author":"Munzel","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.01.049_bb0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(81)90370-2","article-title":"A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats","volume":"28","author":"de Bold","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jacc.2005.03.051","article-title":"In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: an analysis from the Acute Decompensated Heart Failure National Registry (ADHERE)","volume":"46","author":"Abraham","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0100","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1253\/circj.69.283","article-title":"Multicenter prospective investigation on efficacy and safety of carperitide for acute heart failure in the 'real world' of therapy","volume":"69","author":"Suwa","year":"2005","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0105","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1253\/circj.CJ-07-0760","volume":"72","author":"Nomura","year":"2008","journal-title":"Circ. J."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0115","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ahj.2017.05.012","article-title":"Effects of serelaxin on the outcome of patients with or without substantial peripheral edema: a subgroup analysis from the RELAX-AHF trial","volume":"190","author":"Gimpelewicz","year":"2017","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0120","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.amjcard.2018.07.023","article-title":"Relation of volume overload to clinical outcomes in acute heart failure (from ASCEND-HF)","volume":"122","author":"Fudim","year":"2018","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2019.01.049_bb0125","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10557-017-6760-z","article-title":"Rationale and design of low-dose administration of carperitide for acute heart failure (LASCAR-AHF)","volume":"31","author":"Nagai","year":"2017","journal-title":"Cardiovasc. Drugs Ther."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318350435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318350435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T21:43:23Z","timestamp":1565214203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318350435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":24,"alternative-id":["S0167527318350435"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.01.049","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of intravenous carperitide versus nitrates as first-line vasodilators on in-hospital outcomes in hospitalized patients with acute heart failure: Insight from a nationwide claim-based database","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.01.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}