{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T02:42:26Z","timestamp":1774406546625,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T00:00:00Z","timestamp":1582416000000},"content-version":"am","delay-in-days":328,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL135623"],"award-info":[{"award-number":["HL135623"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA041492"],"award-info":[{"award-number":["DA041492"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD088039"],"award-info":[{"award-number":["HD088039"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL118861"],"award-info":[{"award-number":["HL118861"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008891","name":"Loma Linda University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ijcard.2019.01.099","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T19:56:16Z","timestamp":1548964576000},"page":"82-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Epigenetic down-regulation of BKCa channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life"],"prefix":"10.1016","volume":"281","author":[{"given":"Bailin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiranjib","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Walayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daliao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2019.01.099_bb0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/siny.2000.0025","article-title":"Perinatal complications associated with maternal tobacco use","volume":"5","author":"Andres","year":"2000","journal-title":"Semin. Neonatol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0010","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/toxsci\/kfq103","article-title":"Long-term consequences of fetal and neonatal nicotine exposure: a critical review","volume":"116","author":"Bruin","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0015","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1542\/peds.2010-1399","article-title":"Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study","volume":"127","author":"Alverson","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-3782(99)00064-X","article-title":"Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood","volume":"57","author":"Blake","year":"2000","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.bjp.0702061","article-title":"Augmented myocardial ischemia by nicotine-mechanisms and their possible significance","volume":"125","author":"Schror","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0030","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/01.CIR.73.4.662","article-title":"Smoking induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alteration in coronary artery tone","volume":"73","author":"Winniford","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0035","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejphar.2008.05.044","article-title":"Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life","volume":"590","author":"Gao","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0040","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/jpet.107.132175","article-title":"Prenatal nicotine exposure increases heart susceptibility to ischemia\/reperfusion injury in adult offspring","volume":"324","author":"Lawrence","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0045","doi-asserted-by":"crossref","first-page":"76865","DOI":"10.18632\/oncotarget.20172","article-title":"Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring","volume":"8","author":"Ke","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0050","doi-asserted-by":"crossref","first-page":"17615","DOI":"10.1073\/pnas.1206432109","article-title":"Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function","volume":"109","author":"Bernardo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0055","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.1174381","article-title":"MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice","volume":"324","author":"Bonauer","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0060","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCULATIONAHA.113.001904","article-title":"Inhibition of microRNA-92a protects against ischemia\/reperfusion injury in a larger-animal model","volume":"128","author":"Hinkel","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0065","doi-asserted-by":"crossref","first-page":"E1213","DOI":"10.1210\/jc.2012-1008","article-title":"Decreased miR-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery disease","volume":"97","author":"Hulsmans","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0070","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2119\/molmed.2015.00096","article-title":"Signature of miR-181a on the renal transcriptome and blood pressure","volume":"21","author":"Marques","year":"2015","journal-title":"Mol. Med."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0075","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1159\/000453209","article-title":"Circulating miR-181a as a potential novel biomarker for diagnosis of acute myocardial infarction","volume":"40","author":"Zhu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0080","doi-asserted-by":"crossref","first-page":"R1366","DOI":"10.1152\/ajpregu.00704.2009","article-title":"Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring","volume":"298","author":"Khorram","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056967","article-title":"Maternal stress induces epigenetic signatures of psychiatric and neurological diseases in the offspring","volume":"8","author":"Zucchi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0090","first-page":"53","article-title":"Cigarette smoke exposure-associated alterations to non-coding RNA","volume":"3","author":"Maccani","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0095","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/scd.2012.0434","article-title":"Nicotine alters microRNA expression and hinders human adult stem cell regenerative potential","volume":"22","author":"Ng","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0100","first-page":"79","article-title":"Chronic nicotine exposure systemically alters microRNA expression profiles during post-embryonic stage in Caenorhabditis elegans","volume":"229","author":"Taki","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0105","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1007\/s13277-014-1968-z","article-title":"Nicotine upregulates microRNA-21 and promotes TGF-\u03b2-dependent epithelial-mesenchymal transition of esophageal cancer cells","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0110","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1126\/science.1373909","article-title":"Regulation of arterial tone by activation of calcium-dependent potassium channels","volume":"256","author":"Brayden","year":"1992","journal-title":"Sciences"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0115","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.healun.2009.06.011","article-title":"Role of large-conductance calcium-activated potassium channels of coronary arteries in heart preservation","volume":"28","author":"Han","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0120","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1469-7793.1997.545bj.x","article-title":"Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha\u202f+\u202fbeta subunit complexes","volume":"502","author":"Tanaka","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0125","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.RES.0000100068.43006.36","article-title":"Downregulation of the BK channel \u03b21 subunit in genetic hypertension","volume":"93","author":"Amberg","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0130","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1113\/jphysiol.2004.068676","article-title":"Functional and molecular evidence of MaxiK channel \u03b21 subunit decrease with coronary artery ageing in the rat","volume":"559","author":"Nishimaru","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0135","first-page":"11","article-title":"Protective effect of antenatal antioxidant on nicotine-induced heart ischemia-sensitive phenotype in rat offspring","volume":"e0150557","author":"Xiao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0140","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.resp.2009.09.015","article-title":"Prenatal nicotine exposure alters respiratory long-term facilitation in neonatal rats","volume":"169","author":"Fuller","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0145","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1152\/jappl.2001.90.5.1968","article-title":"Threshold levels of maternal nicotine impairing protective responses of newborn rats to intermittent hypoxia","volume":"90","author":"Fewell","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0150","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/HYPERTENSIONAHA.109.138024","article-title":"Prenatal cocaine exposure causes sex-dependent impairment in the myogenic reactivity of coronary arteries in adult offspring","volume":"54","author":"Xiao","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1113\/JP271626","article-title":"Direct effect of chronic hypoxia in suppressing large conductance Ca2+-activated K+ channel activity in ovine uterine arteries via increasing oxidative stress","volume":"594","author":"Hu","year":"2016","journal-title":"J. Physiol."},{"issue":"23","key":"10.1016\/j.ijcard.2019.01.099_bb0160","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1113\/JP276058","article-title":"Long-term high altitude hypoxia during gestation suppresses large conductance Ca2+-activated K+-channel function in uterine arteries: a causal role for microRNA-210","volume":"596","author":"Hu","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0165","doi-asserted-by":"crossref","first-page":"76","DOI":"10.7150\/ijbs.17278","article-title":"Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats","volume":"13","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0170","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/j.1476-5381.2011.01437.x","article-title":"Antenatal nicotine induces heightened oxidative stress and vascular dysfunction in rat offspring","volume":"164","author":"Xiao","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0175","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1152\/physrev.00029.2005","article-title":"Cross-talk between cardiac muscle and coronary vasculature","volume":"86","author":"Westerhof","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0180","doi-asserted-by":"crossref","first-page":"H674","DOI":"10.1152\/ajpheart.00191.2005","article-title":"Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy","volume":"289","author":"Hemmings","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0185","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1043-2760(02)00689-6","article-title":"Fetal programming of coronary heart disease","volume":"13","author":"Barker","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCRESAHA.111.244442","article-title":"Inhibition of miR-15 protects against cardiac ischemic injury","volume":"10","author":"Hullinger","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0195","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/thx.2006.061630","article-title":"Association of maternal smoking with increased infant oxidative stress at 3\u202fmonths of age","volume":"62","author":"Noakes","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0200","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.freeradbiomed.2008.02.010","article-title":"Maternal nicotine exposure increases oxidative in the offspring","volume":"44","author":"Bruin","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0205","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1753-0407.2012.00195.x","article-title":"Maternal antioxidants prevent \u03b2-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure","volume":"4","author":"Bruin","year":"2012","journal-title":"J. Diabetes"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0210","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/960362","article-title":"Effects of downregulation of microRNA-181a on H2O2-induced H9c2 cell apoptosis via the mitochondrial apoptotic pathway","volume":"2014","author":"Wang","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0215","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1124\/jpet.104.074476","article-title":"Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning","volume":"312","author":"Cao","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0220","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1158\/1078-0432.CCR-16-0303","article-title":"Genetic and methylation-induced loss of miR-181a2\/181b2 within chr9q33.3 facilitates tumor growth of cervical cancer through the PIK3R3\/Akt\/FoxO signaling pathway","volume":"23","author":"Mei","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0225","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.4161\/cbt.6.8.4486","article-title":"DNA methylation regulated microRNA expression","volume":"6","author":"Han","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.ijcard.2019.01.099_bb0230","doi-asserted-by":"crossref","unstructured":"McCarthy DM, Morgan TJ Jr, Lowe SE, Williamson MJ, Spencer TJ, Biederman J, et al. Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants. PLoS Biol. 2018; 16:e2996497.","DOI":"10.1371\/journal.pbio.2006497"},{"key":"10.1016\/j.ijcard.2019.01.099_bb0235","doi-asserted-by":"crossref","first-page":"7286","DOI":"10.1038\/s41598-017-07920-3","article-title":"Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b","volume":"7","author":"Dai","year":"2017","journal-title":"Sci. Rep."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318357437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318357437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:41:21Z","timestamp":1759092081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318357437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":47,"alternative-id":["S0167527318357437"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.01.099","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic down-regulation of BKCa channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.01.099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}