{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:45:52Z","timestamp":1781333152511,"version":"3.54.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ijcard.2019.02.066","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T10:53:49Z","timestamp":1552992829000},"page":"97-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Tight systolic blood pressure control with combination therapy decreases type 2 endoleaks in patients undergoing endovascular aneurysm repair"],"prefix":"10.1016","volume":"285","author":[{"given":"Patrizia","family":"Lo Sapio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Chisci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Botteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-3182","authenticated-orcid":false,"given":"Filippo","family":"Turini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Michelagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"41","key":"10.1016\/j.ijcard.2019.02.066_bb0005","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0010","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(04)16979-1","article-title":"Comparison of endo vascular aneurysmrepair with open repair in patients with abdominal aortic aneurysm(EVAR trial 1), 30-day operative mortality results: randomised controlled trial","volume":"364","author":"EVAR trial participants","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0015","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1056\/NEJMoa042002","article-title":"A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms","volume":"351","author":"Prinssen","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0020","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1056\/NEJMoa0909499","article-title":"Long-term outcome of open or endovascular repair of abdominal aortic aneurysm","volume":"362","author":"De Bruin","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0025","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1056\/NEJMoa1207481","article-title":"Long-term comparison of endovascular and open repair of abdominal aortic aneurysm","volume":"367","author":"Lederle","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0030","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/S0140-6736(16)31135-7","article-title":"Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial","volume":"388","author":"Pate","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0035","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/bjs.10430","article-title":"Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5\u202fyears","volume":"104","author":"Powell","year":"2017","journal-title":"Br. J. Surg."},{"issue":"2","key":"10.1016\/j.ijcard.2019.02.066_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170600","article-title":"Prevalence and risk factors of type II endoleaks after endovascular aneurysm repair: a meta-analysis","volume":"12","author":"Guo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1067\/mva.2000.108278","article-title":"Endoleak as a predictor of outcome after endovascular aneurysm repair:AneuRx multicenter clinical trial","volume":"32","author":"Zarins","year":"2000","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0050","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10016-005-9382-z","article-title":"Clinical significance of type II endoleak after endovascular repair of abdominal aortic aneurysm","volume":"20","author":"Gelfand","year":"2006","journal-title":"Ann. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0060","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejvs.2003.10.016","article-title":"Is a type II endoleak after EVAR a harbinger of risk? Causes and outcome of open conversion and aneurysm rupture during follow-up","volume":"27","author":"Van Marrewijk","year":"2004","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0065","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s00270-015-1191-3","article-title":"Systolic sac pressure index for the prediction of persistent type II Endoleak for 12 months after endovascular abdominal aortic aneurysm repair","volume":"39","author":"Ikoma","year":"2016","journal-title":"Cardiovasc. Intervent. Radiol."},{"issue":"1","key":"10.1016\/j.ijcard.2019.02.066_bb0070","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jvs.2017.05.118","article-title":"Postoperative initial 2-day blood pressure management facilitates the shrinkage of abdominal aortic aneurysm after endovascular aneurysm repair by reducing the incidence of type II endoleak","volume":"67","author":"Miura","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvs.2007.02.073","article-title":"Persistent type 2 endoleak after endovascular repair of abdominal aortic aneurysm is associated with adverse late outcomes","volume":"46","author":"Jones","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0080","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jvs.2006.04.058","article-title":"An 8-13 year experience with type II endoleaks: natural history suggests selective intervention is a safe approach","volume":"44","author":"Silverberg","year":"2006","journal-title":"J. Vasc. Surg."},{"issue":"7","key":"10.1016\/j.ijcard.2019.02.066_bb0085","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jamacardio.2017.1421","article-title":"Systolic blood pressure reduction and risk of cardiovascular disease and mortality","volume":"2","author":"Bundy","year":"2017","journal-title":"JAMA Cardiol."},{"issue":"2013","key":"10.1016\/j.ijcard.2019.02.066_bb0090","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","article-title":"ESH\/ESC guidelines for the management of arterialhypertension. The task force for the management of arterial hypertension ofthe European Society of Hypertension (ESH) and of the European society ofCardiology (ESC)","volume":"31","author":"Mancia","year":"2013","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0095","year":"2018"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0100","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jvs.2010.06.110","article-title":"Long-term outcomes of secondary procedures after endovascular aneurysm repair","volume":"52","author":"Manish","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0105","first-page":"53","article-title":"Endoleak after endovascular aortic repair: classification, diagnosis and management following endovascular thoracic and abdominal aortic repair","volume":"51","author":"Cao","year":"2010","journal-title":"J. Cardiovasc. Surg."},{"issue":"4 Suppl","key":"10.1016\/j.ijcard.2019.02.066_bb0110","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jvs.2009.07.002","article-title":"The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice guidelines","volume":"50","author":"Chaikof","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0741-5214(02)75467-0","article-title":"Technique and results of transfemoral superselective coil embolization of type II lumbar endoleak","volume":"38","author":"Kasirajan","year":"2003","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0741-5214(02)32021-4","article-title":"Treatment of type 2 endoleaks after endovascular repair of abdominal aortic aneurysms: comparison of transarterial and translumbar techniques","volume":"35","author":"Baum","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/S0741-5214(03)00084-3","article-title":"Management of endoleak after endovascular aneurysm repair: cuffs, coils, and conversion","volume":"37","author":"Faries","year":"2003","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0130","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1046\/j.1365-2168.2000.01661.x","article-title":"Need for secondary interventions after endovascular repair of abdominal aortic aneurysms: intermediate-term follow-up results of a European collaborativeregistry (EUROSTAR)","volume":"87","author":"Laheij","year":"2000","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0135","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1067\/mva.2002.126542","article-title":"Mechanism of failure in the treatment of type II endoleak with percutaneous coil embolization","volume":"36","author":"Solis","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0140","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jvs.2012.02.038","article-title":"Improved long-term results using Onyx glue for thetreatment of persistent type 2 endoleak after endovascular aneurysm repair","volume":"56","author":"Abularrage","year":"2012","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0145","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1583\/09-3004.1","article-title":"Aneurysm sac \u201cthrombization\u201d and stabilization in EVAR: a technique to reduce the risk of type II endoleak","volume":"17","author":"Ronsivalle","year":"2010","journal-title":"J. Endovasc. Ther."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0150","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jvs.2012.10.078","article-title":"Role of aneurysm sac embolization during endovascular aneurysm repair in the prevention of type II endoleak-related complications","volume":"57","author":"Piazza","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0155","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ejvs.2015.12.009","article-title":"Selective intra-procedural AAA sac embolization during EVAR reduces the rate of type II endoleak","volume":"51","author":"Mascoli","year":"2016","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0160","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/152660280301000210","article-title":"Preoperative embolization of collateral side branches: a valid means to reduce type II endoleaks after endovascular AAA repair","volume":"10","author":"Bonvini","year":"2003","journal-title":"J. Endovasc. Ther."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0165","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/152660280701400509","article-title":"Strategies to reduce the rate of type II endoleaks: routine intraoperative embolization of the inferior mesenteric artery and thrombin injection into the aneurysm sac","volume":"14","author":"Muthu","year":"2007","journal-title":"J. Endovasc. Ther."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0170","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1583\/09-3004C.1","article-title":"Commentary:reduction of type II endoleak using embolization of the aneurysm sac during EVAR","volume":"17","author":"Jonker","year":"2010","journal-title":"J. Endovasc. Ther."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0175","doi-asserted-by":"crossref","first-page":"33e40","DOI":"10.1016\/j.jvs.2011.07.092","article-title":"Long-term follow-up of type II endoleak embolization reveals the need for close surveillance","volume":"55","author":"Sarac","year":"2012","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0180","doi-asserted-by":"crossref","first-page":"547e54","DOI":"10.1016\/j.ejvs.2009.11.002","article-title":"Secondary interventions following endovascular aneurysm repair (EVAR) and the enduring value of graft surveillance","volume":"39","author":"Nordon","year":"2010","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0185","doi-asserted-by":"crossref","first-page":"425e30","DOI":"10.1016\/j.ejvs.2008.12.019","article-title":"Is there a benefit of frequent CT follow-up after EVAR?","volume":"37","author":"Dias","year":"2009","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0190","doi-asserted-by":"crossref","first-page":"276e81","DOI":"10.1016\/j.ejvs.2011.11.020","article-title":"Surveillance imaging modality does not affect detection rate of asymptomatic secondary interventions following EVAR","volume":"43","author":"Chisci","year":"2012","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"2","key":"10.1016\/j.ijcard.2019.02.066_bb0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/ejvs.2002.1662","article-title":"Intraaneurysm sac pressure\u2013the holy grail of endoluminal grafting of AAA","volume":"24","author":"Gawenda","year":"2002","journal-title":"Eur. J. Endovasc. Surg."},{"issue":"5","key":"10.1016\/j.ijcard.2019.02.066_bb0200","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00270-010-9813-2","article-title":"Intraoperative sac pressure measurement during endovascular abdominal aortic aneurysm repair","volume":"33","author":"Ishibashi","year":"2010","journal-title":"Cardiovasc. Interv. Radiol."},{"issue":"2","key":"10.1016\/j.ijcard.2019.02.066_bb0205","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jvs.2006.09.060","article-title":"Initial results of wireless pressure sensing for endovascular aneurysm repair: the APEX trial-acute pressure measurement to confirm aneurysm sac exclusion","volume":"45","author":"Ohki","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0210","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(14)62070-5","article-title":"Blood pressure-lowering treatment based on cardiovascular risk: a metaanalysis of individual patient data","volume":"384","author":"Sundstrom","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0215","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jama.2013.184182","article-title":"Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries","volume":"310","author":"Chow","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0220","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/jhh.2009.76","article-title":"Antihypertensive drug therapy and blood pressure control in men and women: an international perspective","volume":"24","author":"Thoenes","year":"2010","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0225","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.phrs.2017.09.011","article-title":"Combination drug treatment in hypertension","volume":"125","author":"Tsioufis","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"366","key":"10.1016\/j.ijcard.2019.02.066_bb0230","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(05)67185-1","author":"Dahlof","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2019.02.066_bb0235","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1056\/NEJMoa0806182","article-title":"Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients","volume":"359","author":"Jamerson","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.02.066_bb0240","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/hr.2014.144","article-title":"Combination therapy of hypertension in the elderly: a subgroup analysis of the combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial","volume":"38","author":"Ogihara","year":"2015","journal-title":"Hypertens. Res."},{"issue":"23","key":"10.1016\/j.ijcard.2019.02.066_bb0245","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1056\/NEJMoa0806182","article-title":"Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients","volume":"359","author":"Jamerson","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.ijcard.2019.02.066_bb0250","doi-asserted-by":"crossref","first-page":"e55807","DOI":"10.1371\/journal.pone.0055807","article-title":"Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE trial","volume":"8","author":"Hata","year":"2013","journal-title":"PLoS One"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318364398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527318364398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:41:32Z","timestamp":1759092092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527318364398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":50,"alternative-id":["S0167527318364398"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.02.066","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tight systolic blood pressure control with combination therapy decreases type 2 endoleaks in patients undergoing endovascular aneurysm repair","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.02.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}