{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:28:55Z","timestamp":1789957735367,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009045","name":"Jagiellonian University Medical College","doi-asserted-by":"publisher","award":["K\/ZDS\/007717"],"award-info":[{"award-number":["K\/ZDS\/007717"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ijcard.2019.05.037","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T01:52:01Z","timestamp":1558144321000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["High prevalence of inherited thrombophilia and antiphospholipid syndrome in myocardial infarction with non-obstructive coronary arteries: Comparison with cryptogenic stroke"],"prefix":"10.1016","volume":"290","author":[{"given":"Konrad","family":"Stepien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wypasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Zalewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"Undas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2019.05.037_bb0005","first-page":"143","article-title":"ESC working group position paper on myocardial infarction with non-obstructive coronary arteries","volume":"38","author":"Agewall","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0010","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ahj.2009.08.004","volume":"158","author":"Gehrie","year":"2009","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijcard.2009.07.001","article-title":"Are patients with angiographically near-normal coronary arteries who present as acute myocardial infarction actually safe?","volume":"146","author":"Kang","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.amjcard.2004.09.014","article-title":"Characteristics and outcomes of patients with acute myocardial infarction and angiographically normal coronary arteries","volume":"95","author":"Larsen","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0025","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/CIRCULATIONAHA.114.011201","article-title":"Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries","volume":"131","author":"Pasupathy","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.05.037_bb0030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/2048872618782414","article-title":"Pathophysiology, diagnosis and management of MINOCA: an update","volume":"8","author":"Scalone","year":"2019","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.ijcard.2019.05.037_bb0035","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1161\/01.CIR.0000160361.73423.23","article-title":"Atherothrombotic disorders: new insights from hematology","volume":"111","author":"Andreotti","year":"2005","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1477-9560-4-15","article-title":"Hereditary thrombophilia","volume":"4","author":"Khan","year":"2006","journal-title":"Thromb. J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0050","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/euhj.2001.2685","article-title":"Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease","volume":"23","author":"Burzotta","year":"2002","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1067\/mhj.2003.29","article-title":"Potential thrombophilic mutations\/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction","volume":"145","author":"French","year":"2003","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0060","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.atherosclerosis.2007.12.016","article-title":"Role of methylenetetrahydrofolate reductase 677C\u202f\u2192\u202fT polymorphism in the development of premature myocardial infarction","volume":"200","author":"Rallidis","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2019.05.037_bb0065","first-page":"675","article-title":"Abnormalities of haemostasis in myocardial infarction with normal coronary artery","volume":"83","author":"Mohsen","year":"2005","journal-title":"Tunis. Med."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0070","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1056\/NEJMcp1503946","article-title":"Clinical practice. Cryptogenic Stroke","volume":"374","author":"Saver","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.thromres.2010.11.013","article-title":"Thrombophilic screening in young patients (<40\u202fyears) with idiopathic ischemic stroke: a controlled study","volume":"127","author":"Dragoni","year":"2011","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0080","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5482\/ha-1175","article-title":"Thrombophilia screening in young patients with cryptogenic stroke. Prevalence of gene polymorphisms compared to healthy blood donors and impact on secondary stroke prevention","volume":"32","author":"Haeusler","year":"2012","journal-title":"Hamostaseologie."},{"issue":"18","key":"10.1016\/j.ijcard.2019.05.037_bb0085","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.006","article-title":"Clinical impact of thrombophilia screening in young adults with ischemic stroke","volume":"28","author":"Omran","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11239-005-3204-6","article-title":"Antiphospholipid antibodies in young adults with stroke","volume":"20","author":"Brey","year":"2005","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.ijcard.2019.05.037_bb0095","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1161\/STROKEAHA.110.581256","article-title":"Meta-analysis of factor V Leiden and ischemic stroke in young adults: the importance of case ascertainment","volume":"41","author":"Hamedani","year":"2010","journal-title":"Stroke."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0100","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0002-8703(03)00519-2","article-title":"Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies","volume":"146","author":"Kim","year":"2003","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0105","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1001\/archneur.61.11.1652","article-title":"Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls","volume":"61","author":"Casas","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0110","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/STROKEAHA.113.004063","article-title":"The prothrombin G20210A mutation is associated with young-onset stroke: the genetics of early onset stroke study and meta-analysis","volume":"45","author":"Jiang","year":"2014","journal-title":"Stroke."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0115","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Kernan","year":"2014","journal-title":"Stroke."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0120","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1161\/STROKEAHA.108.532812","article-title":"Altered fibrin clot structure\/function in patients with cryptogenic ischemic stroke","volume":"40","author":"Undas","year":"2009","journal-title":"Stroke."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0125","doi-asserted-by":"crossref","first-page":"314","DOI":"10.5603\/KP.a2017.0212","article-title":"Mechanisms of cardioembolic stroke revisited. Atrial cardiopathy","volume":"76","author":"M\u0105czy\u0144ska","year":"2018","journal-title":"Kardiol. Pol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0130","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0135","first-page":"512","article-title":"Genetic characterization of antithrombin, protein C, and protein S deficiencies in Polish patients","volume":"127","author":"Wypasek","year":"2017","journal-title":"Pol. Arch. Intern. Med."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0140","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0145","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1160\/TH13-11-0980","article-title":"Altered fibrin clot structure\/function in patients with antiphospholipid syndrome: association with thrombotic manifestation","volume":"112","author":"Celi\u0144ska-Lowenhoff","year":"2014","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0150","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","article-title":"Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis","volume":"7","author":"Pengo","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0155","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1177\/0961203314531635","article-title":"Multiple antiphospholipid antibodies positivity and antiphospholipid syndrome criteria re-evaluation","volume":"23","author":"Forastiero","year":"2014","journal-title":"Lupus."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0160","doi-asserted-by":"crossref","first-page":"681","DOI":"10.5603\/KP.a2015.0235","article-title":"Multi-centre National Population Health Examination Survey (WOBASZ II study): assumptions, methods, and implementation","volume":"74","author":"Drygas","year":"2016","journal-title":"Kardiol. Pol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0165","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5603\/KP.2013.0066","article-title":"Prevalence and control of cardiovascular risk factors in Poland. Assumptions and objectives of the NATPOL 2011 Survey","volume":"71","author":"Zdrojewski","year":"2013","journal-title":"Kardiol. Pol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0170","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1160\/TH15-02-0141","article-title":"Classic thrombophilic gene variants","volume":"114","author":"Mannucci","year":"2015","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0175","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1111\/j.1538-7836.2010.03982.x","article-title":"The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease","volume":"8","author":"Mannucci","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0180","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(06)68263-9","article-title":"Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls","volume":"367","author":"Ye","year":"2006","journal-title":"Lancet."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0185","first-page":"1134","article-title":"G20210A prothrombin gene variant and clinical outcome in patients with a first acute coronary syndrome","volume":"89","author":"Burzotta","year":"2004","journal-title":"Haematologica."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0190","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/jaut.2000.0409","article-title":"Epidemiology of the antiphospholipid antibody syndrome","volume":"15","author":"Petri","year":"2000","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0195","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2141.2012.09134.x","article-title":"Elevated factor VIII levels and risk of venous thrombosis","volume":"157","author":"Jenkins","year":"2012","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0200","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0609.2006.00656.x","article-title":"Procoagulant factors and the risk of myocardial infarction in young women","volume":"77","author":"Tanis","year":"2006","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0205","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1046\/j.1468-1331.2002.00464.x","article-title":"Risk factors for cryptogenic ischaemic stroke","volume":"9","author":"Karttunen","year":"2002","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0210","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/CIRCULATIONAHA.107.715698","article-title":"Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study","volume":"117","author":"Kamstrup","year":"2008","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2016.08.013","article-title":"Lipoprotein (a) level, apolipoprotein (a) size, and risk of unexplained ischemic stroke in young and middle-aged adults","volume":"253","author":"Beheshtian","year":"2016","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0220","first-page":"135","article-title":"Lipoprotein(a) concentrations are increased in patients with myocardial infarction and angiographically normal coronary arteries","volume":"31","author":"Graziani","year":"1993","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0225","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1160\/TH15-06-0478","article-title":"Uncertain thrombophilia markers","volume":"115","author":"Franchini","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0230","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1001\/jama.296.22.2720","article-title":"Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials","volume":"296","author":"Bazzano","year":"2006","journal-title":"JAMA."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0235","article-title":"Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome","volume":"10","author":"Bala","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0240","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/0961203310395803","article-title":"Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies","volume":"20","author":"Ruiz-Irastorza","year":"2011","journal-title":"Lupus."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0245","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1046\/j.1365-2141.2001.03089.x","article-title":"High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphism in the von Willebrand factor and factor VIII gene","volume":"115","author":"Kamphuisen","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ijcard.2019.05.037_bb0250","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00392-004-0075-3","article-title":"Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases","volume":"93","author":"Stanger","year":"2004","journal-title":"Z. Kardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527319308794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527319308794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T02:26:35Z","timestamp":1663467995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527319308794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":50,"alternative-id":["S0167527319308794"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.05.037","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High prevalence of inherited thrombophilia and antiphospholipid syndrome in myocardial infarction with non-obstructive coronary arteries: Comparison with cryptogenic stroke","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.05.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}