{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:18:04Z","timestamp":1772961484945,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005760","name":"G\u00f6teborgs Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5nes universitetssjukhus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005754","name":"Sahlgrenska Universitetssjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012324","name":"University Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ijcard.2019.06.033","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T11:11:15Z","timestamp":1560510675000},"page":"238-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Toll-like receptor-mediated inflammation markers are strongly induced in heart tissue in patients with cardiac disease under both ischemic and non-ischemic conditions"],"prefix":"10.1016","volume":"293","author":[{"given":"Victoria","family":"Rotter Sopasakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Sandstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Lundqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Jeppsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillemor","family":"Mattsson Hult\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2019.06.033_bb0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.116.308030","article-title":"Chronic heart failure and inflammation: what do we really know?","volume":"119","author":"Dick","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0010","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/CIRCRESAHA.116.302317","article-title":"Innate immunity and the failing heart: the cytokine hypothesis revisited","volume":"116","author":"Mann","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0015","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00995.2008","article-title":"Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart","volume":"296","author":"Chao","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/npjamd.2016.18","article-title":"Macrophages in age-related chronic inflammatory diseases","volume":"2","author":"Oishi","year":"2016","journal-title":"NPJ Aging Mech Dis"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0025","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1111\/febs.14417","article-title":"Chronic inflammation in skeletal muscle impairs satellite cells function during regeneration: can physical exercise restore the satellite cell niche?","volume":"285","author":"Perandini","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0030","doi-asserted-by":"crossref","first-page":"H1311","DOI":"10.1152\/ajpheart.00119.2008","article-title":"Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice","volume":"295","author":"Feng","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0035","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.4049\/jimmunol.180.10.6954","article-title":"Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice","volume":"180","author":"Riad","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0040","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1161\/01.CIR.0000109642.27985.FA","article-title":"Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes","volume":"109","author":"Diwan","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0045","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/CIRCULATIONAHA.106.646091","article-title":"Critical role of monocyte chemoattractant protein-1\/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy","volume":"115","author":"Frangogiannis","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0050","doi-asserted-by":"crossref","first-page":"16029","DOI":"10.1073\/pnas.1406508111","article-title":"Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart","volume":"111","author":"Lavine","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-5273(02)00470-9","article-title":"How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH","volume":"86","author":"Anker","year":"2002","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0060","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1161\/01.CIR.0000077913.60364.D2","volume":"107","author":"Chung","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0065","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/01.CIR.0000124490.27666.B2","article-title":"Targeted anticytokine therapy in patients with chronic heart failure: results of the randomized Etanercept worldwide evaluation (RENEWAL)","volume":"109","author":"Mann","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0070","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004373","article-title":"Interleukin-1 blockade in recently decompensated systolic heart failure: results from REDHART (Recently Decompensated Heart Failure Anakinra Response Trial)","volume":"10","author":"Van Tassell","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0075","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-inflammatory therapy with Canakinumab for the prevention of hospitalization for heart failure","volume":"139","author":"Everett","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0080","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJMoa1809798","article-title":"Low-dose methotrexate for the prevention of atherosclerotic events","volume":"380","author":"Ridker","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0085","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fphys.2014.00496","article-title":"Ischemia\/reperfusion activates myocardial innate immune response: the key role of the toll-like receptor","volume":"5","author":"Vilahur","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0090","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.yjmcc.2010.11.003","article-title":"Therapeutic targeting of innate immunity in the failing heart","volume":"51","author":"Topkara","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0100","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.cell.2007.09.008","article-title":"Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide","volume":"130","author":"Jin","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0105","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1189\/jlb.2VMR1215-582R","article-title":"The RP105\/MD-1 complex: molecular signaling mechanisms and pathophysiological implications","volume":"101","author":"Schultz","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0110","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.4049\/jimmunol.1502599","article-title":"TLR10 is a negative regulator of both MyD88-dependent and -independent TLR signaling","volume":"196","author":"Jiang","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0115","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4049\/jimmunol.1601335","article-title":"TLR10 is a B cell intrinsic suppressor of adaptive immune responses","volume":"198","author":"Hess","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0120","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/cvr\/cvw162","article-title":"Expression and function of IL-1R8 (TIR8\/SIGIRR): a regulatory member of the IL-1 receptor family in platelets","volume":"111","author":"Anselmo","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fimmu.2016.00149","article-title":"Regulatory role of IL-1R8 in immunity and disease","volume":"7","author":"Molgora","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000055916","article-title":"Cytokine production and antibodies against heat shock protein 60 in cardiomyopathies of different origins","volume":"68","author":"Mandi","year":"2000","journal-title":"Pathobiology"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bbrc.2012.11.070","article-title":"Reduced expression of NLRP3 and MEFV in human ischemic heart tissue","volume":"430","author":"Hermansson","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0140","first-page":"029","article-title":"Systemic transcriptional alterations of innate and adaptive immune signaling pathways in atherosclerosis, ischemia stroke, and myocardial infarction","volume":"7","author":"Barr","year":"2015","journal-title":"J. Bioanal. Biomed."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0145","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.numecd.2015.12.005","article-title":"Epicardial adipocyte hypertrophy: association with M1-polarization and toll-like receptor pathways in coronary artery disease patients","volume":"26","author":"Vianello","year":"2016","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0150","first-page":"34","article-title":"Innate immunity in the adult mammalian heart: for whom the cell tolls","volume":"121","author":"Mann","year":"2010","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0155","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/cvr\/cvt047","article-title":"Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes","volume":"98","author":"Tian","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0160","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1053-2498(03)00106-2","article-title":"Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices","volume":"23","author":"Birks","year":"2004","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0165","doi-asserted-by":"crossref","first-page":"19725","DOI":"10.1073\/pnas.1108586108","article-title":"The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse","volume":"108","author":"Mezzaroma","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0170","doi-asserted-by":"crossref","first-page":"H3052","DOI":"10.1152\/ajpheart.01355.2006","article-title":"HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway","volume":"292","author":"Gupta","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0175","doi-asserted-by":"crossref","first-page":"31308","DOI":"10.1074\/jbc.M111.246124","article-title":"Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and toll-like receptor 4","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0180","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2119\/molmed.2014.00058","article-title":"Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: the proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4","volume":"20","author":"Jin","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0185","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/hrt.2003.028092","article-title":"Myocardial ischaemia and the inflammatory response: release of heat shock protein 70 after myocardial infarction","volume":"91","author":"Dybdahl","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0190","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1097\/TP.0b013e318286483a","article-title":"Upregulation of IL-1beta, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury","volume":"95","author":"Lunsford","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.ijcard.2019.06.033_bb0195","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/CIRCRESAHA.116.304269","article-title":"Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration","volume":"116","author":"O'Meara","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0200","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbrc.2014.08.109","article-title":"Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent","volume":"452","author":"Li","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0205","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00005-015-0357-7","article-title":"Inflammatory markers change with age, but do not fall beyond reported normal ranges","volume":"64","author":"Wyczalkowska-Tomasik","year":"2016","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0210","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1381\/096089204323093345","article-title":"The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss","volume":"14","author":"Cottam","year":"2004","journal-title":"Obes. Surg."},{"key":"10.1016\/j.ijcard.2019.06.033_bb0215","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5551\/jat.22533","article-title":"Toll-like receptor, lipotoxicity and chronic inflammation: the pathological link between obesity and cardiometabolic disease","volume":"21","author":"Eguchi","year":"2014","journal-title":"J. Atheroscler. Thromb."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527319306850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527319306850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:43:08Z","timestamp":1759092188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527319306850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":43,"alternative-id":["S0167527319306850"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.06.033","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like receptor-mediated inflammation markers are strongly induced in heart tissue in patients with cardiac disease under both ischemic and non-ischemic conditions","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2019.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}