{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:26:43Z","timestamp":1769848003145,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.ijcard.2020.02.069","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T02:32:15Z","timestamp":1582770735000},"page":"168-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Cardiopulmonary dysfunction in adults with a small, unrepaired ventricular septal defect: A long-term follow-up"],"prefix":"10.1016","volume":"306","author":[{"given":"Filip","family":"Eckerstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Emil","family":"Rex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Maagaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Heiberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sune","family":"Rubak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Redington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke Elisabeth","family":"Hjortdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2020.02.069_bb0005","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1053\/euhj.1998.1083","article-title":"Small ventricular septal defects in adults","volume":"19","author":"Neumayer","year":"1998","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijcard.2016.01.208","article-title":"Clinical course and potential complications of small ventricular septal defects in adulthood: late development of left ventricular dysfunction justifies lifelong care","volume":"208","author":"Karonis","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0015","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.amjcard.2009.09.047","article-title":"Behavior of unrepaired perimembranous ventricular septal defect in young adults","volume":"105","author":"Soufflet","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0020","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijcard.2018.06.109","article-title":"Surgical closure of a ventricular septal defect in early childhood leads to altered pulmonary function in adulthood: A long-term follow-up","volume":"274","author":"Rex","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0025","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ijcard.2016.10.086","article-title":"Small, unrepaired ventricular septal defects reveal poor exercise capacity compared with healthy peers: a prospective, cohort study","volume":"227","author":"Maagaard","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0030","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1164\/ajrccm.152.4.7551393","article-title":"Increased respiratory system resistance and bronchial smooth muscle hypertrophy in children with acute postoperative pulmonary hypertension","volume":"152","author":"Schindler","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0035","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.CIR.58.6.1107","article-title":"Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease","volume":"58","author":"Rabinovitch","year":"1978","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0040","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1099-0496(199601)21:1<42::AID-PPUL7>3.0.CO;2-S","article-title":"Lung mechanics in infants with left-to-right shunt congenital heart disease","volume":"21","author":"Yau","year":"1996","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0045","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s00246-010-9778-6","article-title":"Pulmonary function in children after surgical and percutaneous closure of atrial septal defect","volume":"31","author":"Zaqout","year":"2010","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0050","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1136\/hrt.80.5.484","article-title":"Pulmonary function in children with atrial septal defect before and after heart surgery","volume":"80","author":"Sulc","year":"1998","journal-title":"Heart."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02505804","article-title":"Lung function in VSD patients after corrective heart surgery","volume":"17","author":"\u0160ulc","year":"1996","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0060","article-title":"Impaired ventilatory efficiency after closure of atrial or ventricular septal defect","volume":"51","author":"Heiberg","year":"2017","journal-title":"Scand. Cardiovasc. J."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0070","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1183\/09031936.03.00089403","article-title":"The forced oscillation technique in clinical practice: methodology, recommendations and future developments","volume":"22","author":"Oostveen","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1183\/09031936.00069712","article-title":"Consensus statement for inert gas washout measurement using multiple- and single- breath tests","volume":"41","author":"Robinson","year":"2013","journal-title":"Eur. Respir. J."},{"issue":"2017","key":"10.1016\/j.ijcard.2020.02.069_bb0080","article-title":"ERS\/ATS standards for single-breath carbon monoxide uptake in the lung","volume":"49","author":"Graham","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIR.0b013e3181e52e69","article-title":"Clinician's guide to cardiopulmonary exercise testing in adults: a scientific statement from the American heart association","volume":"122","author":"Balady","year":"2010","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0090","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1152\/jappl.1986.60.6.2020","article-title":"A new method for detecting anaerobic threshold by gas exchange","volume":"60","author":"Beaver","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0095","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/rccm.167.2.211","article-title":"Statement on cardiopulmonary exercise testing","volume":"167","author":"ATS\/ACCP","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0100","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1164\/rccm.2202033","article-title":"Ventilatory efficiency during exercise in healthy subjects","volume":"166","author":"Sun","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S1047951113002084","article-title":"Reduced long-term exercise capacity in young adults operated for ventricular septal defect","volume":"25","author":"Heiberg","year":"2015","journal-title":"Cardiol. Young"},{"key":"10.1016\/j.ijcard.2020.02.069_bb0110","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.amjcard.2008.05.063","article-title":"Exercise capacity and participation of children with a ventricular septal defect","volume":"102","author":"Binkhorst","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0115","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF01959785","article-title":"Serial cardiorespiratory exercise testing in patients with congenital heart disease","volume":"154","author":"Reybrouck","year":"1995","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0120","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.amjcard.2010.01.024","article-title":"Right ventricular systolic pressure response during exercise in adolescents born with atrial or ventricular septal defect","volume":"105","author":"M\u00f6ller","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0125","first-page":"147","article-title":"Long-term outcome of patients with perimembranous ventricular septal defect: results from the Belgian registry on adult congenital heart disease","volume":"136","author":"Gabriels","year":"2017","journal-title":"Cardiol."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0130","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1001\/jama.2009.681","article-title":"Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis","volume":"301","author":"Kodama","year":"2009","journal-title":"JAMA."},{"key":"10.1016\/j.ijcard.2020.02.069_bb0135","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/ejcts\/ezw420","article-title":"Does functional capacity depend on the size of the shunt? A prospective, cohort study of adults with small, unrepaired ventricular septal defects","volume":"51","author":"Maagaard","year":"2017","journal-title":"Eur. J. Cardio-Thoracic Surg."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527319318777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527319318777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:47:01Z","timestamp":1759092421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527319318777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":27,"alternative-id":["S0167527319318777"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2020.02.069","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiopulmonary dysfunction in adults with a small, unrepaired ventricular septal defect: A long-term follow-up","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2020.02.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}