{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:24:04Z","timestamp":1790735044182,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ijcard.2020.03.072","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T19:22:59Z","timestamp":1586978579000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Experimental abdominal aortic aneurysm growth is inhibited by blocking the JAK2\/STAT3 pathway"],"prefix":"10.1016","volume":"312","author":[{"given":"Jie","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2020.03.072_bb0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.gheart.2013.12.009","article-title":"Estimation of global and regional incidence and prevalence of abdominal aortic aneurysms 1990 to 2010","volume":"9","author":"Sampson","year":"2014","journal-title":"Glob. Heart"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0010","first-page":"11","article-title":"Abdominal aortic aneurysm: a comprehensive review","volume":"16","author":"Aggarwal","year":"2011","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7326\/0003-4819-142-3-200502010-00012","article-title":"Screening for abdominal aortic aneurysm: a best-evidence systematic review for the U.S. Preventive Services Task Force","volume":"142","author":"Fleming","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0020","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1161\/CIRCULATIONAHA.108.817619","article-title":"Risk factors for abdominal aortic aneurysms: a 7-year prospective study: the Tromso study, 1994-2001","volume":"119","author":"Forsdahl","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0025","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/01.ATV.0000245819.32762.cb","article-title":"Abdominal aortic aneurysm: pathogenesis and implications for management","volume":"26","author":"Golledge","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrcardio.2010.180","article-title":"Pathophysiology and epidemiology of abdominal aortic aneurysms","volume":"8","author":"Nordon","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nm.1958","article-title":"Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms","volume":"15","author":"Satoh","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0040","doi-asserted-by":"crossref","first-page":"103120","DOI":"10.1155\/2012\/103120","article-title":"Pathogenesis of abdominal aortic aneurysms: role of nicotine and nicotinic acetylcholine receptors","volume":"2012","author":"Li","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0074-7696(08)62106-3","article-title":"Angiogenesis: models and modulators","volume":"159","author":"Cockerill","year":"1995","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0050","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0021-9258(17)32755-2","article-title":"Purification and properties of a heat-stable glucocerebrosidase activating factor from control and Gaucher spleen","volume":"252","author":"Peters","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0055","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0060","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1053\/ejvs.2000.1211","article-title":"Activity of matrix metalloproteinase-2 and -9 in abdominal aortic aneurysms. Relation to size and rupture","volume":"20","author":"Petersen","year":"2000","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0065","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/01.CIR.104.3.304","article-title":"Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms","volume":"104","author":"Goodall","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0070","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.immuni.2012.03.014","article-title":"JAK and STAT signaling molecules in immunoregulation and immune-mediated disease","volume":"36","author":"O\u2019Shea","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0075","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak-STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0080","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.humpath.2014.11.003","article-title":"Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak\/Stat pathway","volume":"46","author":"Ghosh","year":"2015","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0085","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1161\/ATVBAHA.114.304435","article-title":"Inhibiting the Th17\/IL-17A-related inflammatory responses with digoxin confers protection against experimental abdominal aortic aneurysm","volume":"34","author":"Wei","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0090","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/cvr\/cvr080","article-title":"Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm","volume":"91","author":"Kaneko","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0095","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/ATVBAHA.109.187757","article-title":"Analysis of in situ and ex vivo vascular endothelial growth factor receptor expression during experimental aortic aneurysm progression","volume":"29","author":"Tedesco","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0100","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1161\/01.ATV.0000234944.22509.f9","article-title":"Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines","volume":"26","author":"Choke","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0105","doi-asserted-by":"crossref","first-page":"16053","DOI":"10.1038\/srep16053","article-title":"Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3\/GIV signaling pathway in non-small-cell lung cancer","volume":"5","author":"Pan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0110","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jbspin.2016.05.014","article-title":"Interleukin-17 upregulates vascular endothelial growth factor by activating the JAK\/STAT pathway in nucleus pulposus cells","volume":"84","author":"Hu","year":"2017","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0115","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1172\/JCI7818","article-title":"Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice","volume":"105","author":"Daugherty","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0120","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ajpath.2013.09.016","article-title":"Phosphorylation of AKT and abdominal aortic aneurysm formation","volume":"184","author":"Ghosh","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1196\/annals.1383.025","article-title":"Abdominal aortic aneurysm as a complex multifactorial disease: interactions of polymorphisms of inflammatory genes, features of autoimmunity, and current status of MMPs","volume":"1085","author":"Pearce","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0130","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/1874192401004010221","article-title":"Experimental models of abdominal aortic aneurysms","volume":"4","author":"Tsui","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0135","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/ATVBAHA.112.300432","article-title":"Genetic and pharmacologic disruption of interleukin-1beta signaling inhibits experimental aortic aneurysm formation","volume":"33","author":"Johnston","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jss.2006.03.026","article-title":"Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during angiotensin II induced aneurysm formation","volume":"135","author":"Eagleton","year":"2006","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0145","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"Yu","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/08977194.2012.660936","article-title":"Biology and significance of the JAK\/STAT signalling pathways","volume":"30","author":"Kiu","year":"2012","journal-title":"Growth Factors"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0155","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/sj.onc.1210031","article-title":"A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo","volume":"26","author":"Iwamaru","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0160","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2020.03.072_bb0165","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1073\/pnas.032652399","article-title":"Stable suppression of gene expression by RNAi in mammalian cells","volume":"99","author":"Paddison","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2020.03.072_bb0170","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1182\/blood-2007-04-083188","article-title":"Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity","volume":"110","author":"Dannull","year":"2007","journal-title":"Blood"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731935212X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731935212X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:47:25Z","timestamp":1759092445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016752731935212X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":34,"alternative-id":["S016752731935212X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2020.03.072","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental abdominal aortic aneurysm growth is inhibited by blocking the JAK2\/STAT3 pathway","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2020.03.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}