{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:15:23Z","timestamp":1775600123960,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.ijcard.2020.12.021","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T01:27:56Z","timestamp":1607995676000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Iron deficiency for prognosis in acute coronary syndrome \u2013 A systematic review and meta-analysis"],"prefix":"10.1016","volume":"328","author":[{"given":"Johannes","family":"Reinhold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charikleia","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranu","family":"Baral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilios S.","family":"Vassiliou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2020.12.021_bb0005","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJM199912233412607","article-title":"Disorders of iron metabolism","volume":"341","author":"Andrews","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0010","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s00018-009-0051-1","article-title":"Mammalian iron transport","volume":"66","author":"Anderson","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0015","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/eurheartj\/ehs224","article-title":"Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives","volume":"34","author":"Jankowska","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrm1620","article-title":"Iron-Sulphur cluster biogenesis and mitochondrial iron homeostasis","volume":"6","author":"Rouault","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0025","doi-asserted-by":"crossref","first-page":"568S","DOI":"10.1093\/jn\/131.2.568S","article-title":"Iron biology in immune function, muscle metabolism and neuronal functioning","volume":"131","author":"Beard","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0030","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0035","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/eurheartj\/ehu385","article-title":"Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiencydagger","volume":"36","author":"Ponikowski","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0040","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.117.027497","article-title":"Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency","volume":"136","author":"van Veldhuisen","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ahj.2013.01.017","article-title":"Iron deficiency in chronic heart failure: an international pooled analysis","volume":"165","author":"Klip","year":"2013","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0050","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrcardio.2011.77","article-title":"Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches","volume":"8","author":"van Veldhuisen","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0055","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/biom8030060","article-title":"Adverse outcome prediction of Iron deficiency in patients with acute coronary syndrome","volume":"8","author":"Zeller","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijcard.2019.07.083","article-title":"Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"300","author":"Cosentino","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0070","first-page":"e344","article-title":"AHA\/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines","volume":"130","author":"Amsterdam","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7326\/0003-4819-158-4-201302190-00009","article-title":"Assessing bias in studies of prognostic factors","volume":"158","author":"Hayden","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0080","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2217\/bmm-2018-0021","article-title":"Iron deficiency and long-term mortality in elderly patients with acute coronary syndrome","volume":"12","author":"Gonzalez-D\u2019Gregorio","year":"2018","journal-title":"Biomark. Med"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0085","article-title":"Does iron deficiency have any prognostic impact in acute coronary syndromes?","volume":"36","author":"Martins","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(13)60207-7","article-title":"Iron deficiency predicts poor outcomes after primary intervention in nonanemic patients with stemi","volume":"61","author":"Fujinaga","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0095","article-title":"Iron deficency and heart failure go hand in hand, but what about iron deficiency and acute coronary syndrome in an ageing population? The iron paradox","volume":"39","author":"Paeres","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0100","series-title":"Revista espanola de cardiologia (English Ed.)","first-page":"363","article-title":"Iron deficiency is a determinant of functional capacity and health-related Quality of life 30 days after an acute coronary syndrome","volume":"70","author":"Mero\u00f1o","year":"2017"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0105","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nm.3212","article-title":"Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I","volume":"19","author":"Chouchani","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0110","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijcard.2016.11.072","article-title":"Catalytic iron in acute myocardial infarction complicated by cardiogenic shock - a biomarker substudy of the IABP-SHOCK II-trial","volume":"227","author":"Fuernau","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0120","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.2337\/diacare.27.11.2730","article-title":"Serum chelatable redox-active iron is an independent predictor of mortality after myocardial infarction in individuals with diabetes","volume":"27","author":"Sulieman","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0125","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/01.CIR.76.4.906","article-title":"Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury","volume":"76","author":"Ambrosio","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0130","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/01.CIR.78.2.442","article-title":"Iron-load increases the susceptibility of rat hearts to oxygen reperfusion damage. Protection by the antioxidant (+)-cyanidanol-3 and deferoxamine","volume":"78","author":"van der Kraaij","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2020.12.021_bb0135","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/CIRCINTERVENTIONS.111.966226","article-title":"Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction","volume":"5","author":"Chan","year":"2012","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0140","doi-asserted-by":"crossref","DOI":"10.1007\/s00392-020-01631-y","article-title":"Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study","author":"Schrage","year":"2020","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0145","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ajcp\/84.5.649","article-title":"Acute changes in iron metabolism following myocardial infarction","volume":"84","author":"Griffiths","year":"1985","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0891-5849(90)90143-7","article-title":"Iron status in the acute phase and six weeks after myocardial infarction","volume":"8","author":"van der Schouw","year":"1990","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijcard.2020.12.021_bb0155","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004519","article-title":"Definition of iron deficiency based on the gold standard of bone marrow iron staining in heart failure patients","volume":"11","author":"Grote Beverborg","year":"2018","journal-title":"Circ. Heart Fail."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527320342698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527320342698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:51:07Z","timestamp":1759092667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527320342698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":31,"alternative-id":["S0167527320342698"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2020.12.021","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron deficiency for prognosis in acute coronary syndrome \u2013 A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2020.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}