{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:26:24Z","timestamp":1791779184687,"version":"4.3.4"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ijcard.2021.02.054","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T04:25:37Z","timestamp":1614399937000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Short-term direct oral anticoagulation or dual antiplatelet therapy following left atrial appendage closure in patients with relative contraindications to chronic anticoagulation therapy"],"prefix":"10.1016","volume":"333","author":[{"given":"Laurent","family":"Faroux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Cruz-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabit","family":"Arzamendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Peral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Caneiro-Queija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Mangieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Trejo-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Asmarats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ander","family":"Regueiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"McInerney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Mas-Llad\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Estevez-Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Laricchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"O'Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2021.02.054_bb0005","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(06)68845-4","article-title":"Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the atrial fibrillation Clopidogrel trial with Irbesartan for prevention of vascular events (ACTIVE W): a randomised controlled trial","volume":"367","author":"Connolly","year":"2006","journal-title":"Lancet."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0010","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1001\/jama.288.19.2441","article-title":"Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis","volume":"288","author":"van Walraven","year":"2002","journal-title":"JAMA."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0015","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.117.005359","article-title":"Percutaneous left atrial appendage closure: current devices and clinical outcomes","volume":"10","author":"Asmarats","year":"2017","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0020","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jcin.2014.03.003","article-title":"Impact of Watchman and Amplatzer devices on left atrial appendage adjacent structures and healing response in a canine model","volume":"7","author":"Kar","year":"2014","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0025","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial","volume":"374","author":"Holmes","year":"2009","journal-title":"Lancet."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","article-title":"Prospective randomized evaluation of the Watchman left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial","volume":"64","author":"Holmes","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0035","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.amjcard.2017.03.253","article-title":"Changes in coagulation and platelet activation markers following Transcatheter left atrial appendage closure","volume":"120","author":"Rod\u00e9s-Cabau","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0040","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jcin.2019.04.004","article-title":"Propensity-matched comparison of Oral anticoagulation versus antiplatelet therapy after left atrial appendage closure with WATCHMAN","volume":"12","author":"S\u00f8ndergaard","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0045","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0050","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/clc.22478","article-title":"Initial experience with novel Oral anticoagulants during the first 45 days after left atrial appendage closure with the Watchman device","volume":"38","author":"B\u00f6sche","year":"2015","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.hrthm.2016.10.020","article-title":"Use of non-warfarin oral anticoagulants instead of warfarin during left atrial appendage closure with the Watchman device","volume":"14","author":"Enomoto","year":"2017","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0060","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.4244\/EIJ-D-17-00042","article-title":"Safety and efficacy of early anticoagulation drug regimens after WATCHMAN left atrial appendage closure: three-month data from the EWOLUTION prospective, multicentre, monitored international WATCHMAN LAA closure registry","volume":"13","author":"Bergmann","year":"2017","journal-title":"EuroIntervention."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0065","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/pace.13796","article-title":"A comparison of postprocedural anticoagulation in high-risk patients undergoing WATCHMAN device implantation","volume":"42","author":"Cohen","year":"2019","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0070","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0075","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1093\/eurheartj\/ehr031","article-title":"An overview of the objectives of and the approaches to propensity score analyses","volume":"32","author":"Heinze","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.009039","article-title":"Short-term oral anticoagulation versus antiplatelet therapy following transcatheter left atrial appendage closure","volume":"13","author":"Asmarats","year":"2020","journal-title":"Circ Cardiovasc. Interv."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0085","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJMoa1300615","article-title":"Dabigatran versus warfarin in patients with mechanical heart valves","volume":"369","author":"Eikelboom","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2021.02.054_bb0090","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.jacep.2018.09.007","article-title":"Incidence and clinical impact of device-related thrombus following percutaneous left atrial appendage occlusion: a meta-analysis","volume":"4","author":"Alkhouli","year":"2018","journal-title":"JACC Clin. Electrophysiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321003636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321003636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:52:26Z","timestamp":1759092746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527321003636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":18,"alternative-id":["S0167527321003636"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.02.054","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-term direct oral anticoagulation or dual antiplatelet therapy following left atrial appendage closure in patients with relative contraindications to chronic anticoagulation therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.02.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}