{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:00:16Z","timestamp":1790863216178,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ijcard.2021.04.061","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T11:43:51Z","timestamp":1619783031000},"page":"126-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Sex-specific temporal evolution of circulating biomarkers in patients with chronic heart failure with reduced ejection fraction"],"prefix":"10.1016","volume":"334","author":[{"given":"M.M.","family":"Schreuder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schuurman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Akkerhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Constantinescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Caliskan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van Ramshorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Germans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.A.","family":"Umans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Roeters van Lennep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kardys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"47","key":"10.1016\/j.ijcard.2021.04.061_bb0005","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehz835","article-title":"Sex differences in heart failure","volume":"40","author":"Lam","year":"2019","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.ijcard.2021.04.061_bb0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0735-1097(02)02696-7","article-title":"Gender, age, and heart failure with preserved left ventricular systolic function","volume":"41","author":"Masoudi","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.ijcard.2021.04.061_bb0015","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/0002-9149(92)90734-G","article-title":"Clinical characteristics of patients in studies of left ventricular dysfunction (SOLVD)","volume":"70","author":"Johnstone","year":"1992","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.ijcard.2021.04.061_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.003116","article-title":"Predicting heart failure with preserved and reduced ejection fraction: the International Collaboration on Heart Failure Subtypes","volume":"9","author":"Ho","year":"2016","journal-title":"Circ. Heart Fail."},{"issue":"14","key":"10.1016\/j.ijcard.2021.04.061_bb0025","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/eurheartj\/ehs070","article-title":"Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community","volume":"33","author":"Ho","year":"2012","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.ijcard.2021.04.061_bb0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0002-9149(74)90089-7","article-title":"Role of diabetes in congestive heart failure: the Framingham study","volume":"34","author":"Kannel","year":"1974","journal-title":"Am. J. Cardiol."},{"issue":"20","key":"10.1016\/j.ijcard.2021.04.061_bb0035","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.1996.03530440037034","article-title":"The progression from hypertension to congestive heart failure","volume":"275","author":"Levy","year":"1996","journal-title":"JAMA."},{"issue":"8","key":"10.1016\/j.ijcard.2021.04.061_bb0040","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jchf.2018.05.018","article-title":"The association of obesity and cardiometabolic traits with incident HFpEF and HFrEF","volume":"6","author":"Savji","year":"2018","journal-title":"JACC Heart Fail."},{"issue":"1","key":"10.1016\/j.ijcard.2021.04.061_bb0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3724\/SP.J.1263.2011.00015","article-title":"Gender differences in the etiology of heart failure: a systematic review","volume":"8","author":"Azad","year":"2011","journal-title":"J. Geriatr. Cardiol."},{"issue":"12","key":"10.1016\/j.ijcard.2021.04.061_bb0050","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ejhf.813","article-title":"Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry","volume":"19","author":"Chioncel","year":"2017","journal-title":"Eur. J. Heart Fail."},{"issue":"1","key":"10.1016\/j.ijcard.2021.04.061_bb0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jacc.2018.09.081","article-title":"Differential impact of heart failure with reduced ejection fraction on men and women","volume":"73","author":"Dewan","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.ijcard.2021.04.061_bb0060","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jacc.2008.04.069","article-title":"Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan Heart Failure Trial)","volume":"52","author":"Masson","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.ijcard.2021.04.061_bb0065","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/CIRCULATIONAHA.104.508465","article-title":"C-reactive protein in heart failure: prognostic value and the effect of valsartan","volume":"112","author":"Anand","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2021.04.061_bb0070","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ahj.2017.10.008","article-title":"Toward personalized risk assessment in patients with chronic heart failure: detailed temporal patterns of NT-proBNP, troponin T, and CRP in the Bio-SHiFT study","volume":"196","author":"van Boven","year":"2018","journal-title":"Am. Heart J."},{"issue":"4","key":"10.1016\/j.ijcard.2021.04.061_bb0075","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.kint.2017.09.013","article-title":"Patient-specific evolution of renal function in chronic heart failure patients dynamically predicts clinical outcome in the bio-SHiFT study","volume":"93","author":"Brankovic","year":"2018","journal-title":"Kidney Int."},{"issue":"14","key":"10.1016\/j.ijcard.2021.04.061_bb0080","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.ijcard.2021.04.061_bb0085","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/CIRCHEARTFAILURE.111.966242","article-title":"Renal dysfunction in patients with heart failure with preserved versus reduced ejection fraction: impact of the new Chronic Kidney Disease-Epidemiology Collaboration Group formula","volume":"5","author":"McAlister","year":"2012","journal-title":"Circ. Heart Fail."},{"issue":"2 Suppl 1","key":"10.1016\/j.ijcard.2021.04.061_bb0090","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"National Kidney F","year":"2002","journal-title":"Am. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.ijcard.2021.04.061_bb0095","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1541-0420.2010.01546.x","article-title":"Dynamic predictions and prospective accuracy in joint models for longitudinal and time-to-event data","volume":"67","author":"Rizopoulos","year":"2011","journal-title":"Biometrics"},{"issue":"7","key":"10.1016\/j.ijcard.2021.04.061_bb0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.18637\/jss.v072.i07","article-title":"The R Package JMbayes for fitting joint models for longitudinal and time-to-event data using MCMC","volume":"72","author":"Rizopoulos","year":"2016","journal-title":"J. Stat. Softw."},{"issue":"32","key":"10.1016\/j.ijcard.2021.04.061_bb0105","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/eurheartj\/eht152","article-title":"Neurohormonal and clinical sex differences in heart failure","volume":"34","author":"Meyer","year":"2013","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.ijcard.2021.04.061_bb0110","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jacc.2011.03.042","article-title":"Influence of sex and hormone status on circulating natriuretic peptides","volume":"58","author":"Lam","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.ijcard.2021.04.061_bb0115","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/CIRCULATIONAHA.116.023005","article-title":"Sex-based differences in cardiometabolic biomarkers","volume":"135","author":"Lew","year":"2017","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ijcard.2021.04.061_bb0120","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/01.CCM.0000055442.84685.4D","article-title":"Sex-based differences in serum cardiac troponin I, a specific marker for myocardial injury, after cardiac surgery","volume":"31","author":"Schwarzenberger","year":"2003","journal-title":"Crit. Care Med."},{"issue":"5","key":"10.1016\/j.ijcard.2021.04.061_bb0125","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0022-5223(95)70058-7","article-title":"Is body size the cause for poor outcomes of coronary artery bypass operations in women?","volume":"110","author":"Christakis","year":"1995","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"6","key":"10.1016\/j.ijcard.2021.04.061_bb0130","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0735-1097(02)01712-6","article-title":"Gender differences and normal left ventricular anatomy in an adult population free of hypertension. A cardiovascular magnetic resonance study of the Framingham Heart Study Offspring cohort","volume":"39","author":"Salton","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.ijcard.2021.04.061_bb0135","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.jacc.2009.09.065","article-title":"Sex-related differences in myocardial remodeling","volume":"55","author":"Piro","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.ijcard.2021.04.061_bb0140","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.RES.85.9.856","article-title":"Myocyte death in the failing human heart is gender dependent","volume":"85","author":"Guerra","year":"1999","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.ijcard.2021.04.061_bb0145","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1210\/en.2008-0708","article-title":"Rapid estrogen receptor-alpha activation improves ischemic tolerance in aged female rats through a novel protein kinase C epsilon-dependent mechanism","volume":"150","author":"Novotny","year":"2009","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.ijcard.2021.04.061_bb0150","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jacc.2005.04.051","article-title":"Race and gender differences in C-reactive protein levels","volume":"46","author":"Khera","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2021.04.061_bb0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/13547500410001670303","article-title":"Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones","volume":"9","author":"Rogowski","year":"2004","journal-title":"Biomarkers"},{"issue":"3","key":"10.1016\/j.ijcard.2021.04.061_bb0160","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000443691","article-title":"Relations of visceral and abdominal subcutaneous adipose tissue, body mass index, and waist circumference to serum concentrations of parameters of chronic inflammation","volume":"9","author":"Schlecht","year":"2016","journal-title":"Obes. Facts"},{"issue":"10","key":"10.1016\/j.ijcard.2021.04.061_bb0165","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/dme.14059","article-title":"Gender difference in the impact of coexisting diabetes mellitus on long-term clinical outcome in people with heart failure: a report from the Korean Heart Failure Registry","volume":"36","author":"Kim","year":"2019","journal-title":"Diabet. Med."},{"issue":"1","key":"10.1016\/j.ijcard.2021.04.061_bb0170","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1523-1755.1999.00260.x","article-title":"Impact of gender on the renal response to angiotensin II","volume":"55","author":"Miller","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.ijcard.2021.04.061_bb0175","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2369-11-20","article-title":"Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients","volume":"11","author":"Xu","year":"2010","journal-title":"BMC Nephrol."},{"issue":"3","key":"10.1016\/j.ijcard.2021.04.061_bb0180","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10620-017-4897-z","article-title":"Cystatin C is a gender-neutral glomerular filtration rate biomarker in patients with cirrhosis","volume":"63","author":"Mindikoglu","year":"2018","journal-title":"Dig. Dis. Sci."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321008044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321008044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:52:33Z","timestamp":1759092753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527321008044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":36,"alternative-id":["S0167527321008044"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.04.061","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific temporal evolution of circulating biomarkers in patients with chronic heart failure with reduced ejection fraction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.04.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}