{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:50Z","timestamp":1790279150358,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ijcard.2021.07.060","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T19:18:52Z","timestamp":1627759132000},"page":"117-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Cardiovascular manifestations in hospitalized patients with hemochromatosis in the United States"],"prefix":"10.1016","volume":"342","author":[{"given":"Kunjan","family":"Udani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abimbola","family":"Chris-Olaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chima","family":"Ohadugha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaqib","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilian","family":"Sansbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Paari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ijcard.2021.07.060_bb0005","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1182\/blood-2008-04-148767","article-title":"Longitudinal analysis of heart and liver iron in thalassemia major","volume":"112","author":"Noetzli","year":"2008","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ijcard.2021.07.060_bb0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/ajh.22205","article-title":"Electrocardiographic consequences of cardiac iron overload in thalassemia major","volume":"87","author":"Detterich","year":"2012","journal-title":"Am. J. Hematol."},{"issue":"11","key":"10.1016\/j.ijcard.2021.07.060_bb0015","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.2337\/dc20-0908","article-title":"The close link of pancreatic iron with glucose metabolism and with cardiac complications in thalassemia major: a large, multicenter observational study","volume":"43","author":"Pepe","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2021.07.060_bb0020","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1056\/NEJM199306033282208","article-title":"Screening for hemochromatosis","volume":"328","author":"Edwards","year":"1993","journal-title":"NEJM"},{"key":"10.1016\/j.ijcard.2021.07.060_bb0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0002-9343(91)90604-V","article-title":"Clinical presentation of hemochromatosis: a changing scene","volume":"90","author":"Adams","year":"1991","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ijcard.2021.07.060_bb0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-1-4615-2554-7_31","article-title":"Epidemiology, clinical spectrum, and prognosis of hemochromatosis","volume":"356","author":"Niederau","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.ijcard.2021.07.060_bb0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ehjci\/jex012","article-title":"Prediction of cardiac complications for thalassemia major in the widespread cardiac magnetic resonance era: a prospective multicentre study by a multi-parametric approach","volume":"19","author":"Pepe","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2021.07.060_bb0040","author":"Centers for Disease Control and Prevention"},{"issue":"3","key":"10.1016\/j.ijcard.2021.07.060_bb0045","first-page":"183","article-title":"Hereditary hemochromatosis","volume":"87","author":"Crownover","year":"2013","journal-title":"Am. Fam. Physician"},{"issue":"4","key":"10.1016\/j.ijcard.2021.07.060_bb0050","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0002-9149(01)01684-8","article-title":"Hemochromatosis gene variants in patients with cardiomyopathy","volume":"88","author":"Pereira","year":"2001","journal-title":"Am. J. Cardiol."},{"issue":"9","key":"10.1016\/j.ijcard.2021.07.060_bb0055","first-page":"1159","article-title":"Thalassemia. A few new tiles in a large mosaic","volume":"91","author":"Borgna-Pignatti","year":"2006","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.ijcard.2021.07.060_bb0060","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/bjh.15125","article-title":"Gender differences in the development of cardiac complications: a multicentre study in a large cohort of thalassaemia major patients to optimize the timing of cardiac follow up","volume":"180","author":"Pepe","year":"2018","journal-title":"Br. J. Haematol."},{"issue":"13","key":"10.1016\/j.ijcard.2021.07.060_bb0065","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jacc.2010.03.083","article-title":"(2010). Iron overload cardiomyopathy: better understanding of an increasing disorder","volume":"56","author":"Gujja","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2021.07.060_bb0070","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/CBO9780511666476.029","article-title":"Cardiac abnormalities in hemochromatosis","author":"Muhlestein","year":"2000","journal-title":"Hemochromatosis: Genet. Pathophysiol. Diagn. Treat."},{"key":"10.1016\/j.ijcard.2021.07.060_bb0075","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/CIRCULATIONAHA.110.007641","article-title":"On T2\u204e magnetic resonance and cardiac Iron","volume":"123","author":"Carpenter","year":"2011","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ijcard.2021.07.060_bb0080","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3324\/haematol.2010.025510","article-title":"Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: a T2\u204e magnetic resonance imaging study","volume":"96","author":"Marsella","year":"2011","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.ijcard.2021.07.060_bb0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pcad.2007.10.003","article-title":"Sudden cardiac death in infiltrative cardiomyopathies: sarcoidosis, scleroderma, amyloidosis, hemochromatosis","volume":"51","author":"Lubitz","year":"2008","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"4","key":"10.1016\/j.ijcard.2021.07.060_bb0090","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/joa3.12208","article-title":"Iron overload and arrhythmias: influence of confounding factors","volume":"35","author":"Shizukuda","year":"2019","journal-title":"J. Arrhythmia"},{"issue":"4","key":"10.1016\/j.ijcard.2021.07.060_bb0095","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-0609.2011.01579.x","article-title":"Dispersion of repolarization and beta-thalassemia major: the prognostic role of QT and JT dispersion for identifying the high-risk patients for sudden death","volume":"86","author":"Russo","year":"2011","journal-title":"Eur. J. Haematol."},{"issue":"1","key":"10.1016\/j.ijcard.2021.07.060_bb0100","first-page":"103","article-title":"Effect of iron loading on transmembrane potential, contraction, and automaticity of rat ventricular muscle cells in culture","volume":"113","author":"Link","year":"1989","journal-title":"J. Lab. Clin. Med."},{"issue":"11","key":"10.1016\/j.ijcard.2021.07.060_bb0105","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1111\/echo.14141","article-title":"Can two-dimensional speckle tracking echocardiography be useful for the left ventricular assessment in the early stages of hereditary haemochromatosis?","volume":"35","author":"Katarzyna","year":"2018","journal-title":"Echocardiography"},{"issue":"1","key":"10.1016\/j.ijcard.2021.07.060_bb0110","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12947-019-0174-y","article-title":"Global longitudinal strain as an Indicator of cardiac Iron overload in thalassemia patients","volume":"17","author":"Abtahi","year":"2019","journal-title":"Cardiovasc. Ultrasound"},{"issue":"2","key":"10.1016\/j.ijcard.2021.07.060_bb0115","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/CRD.0b013e3182a67805","article-title":"Cardiac involvement in hemochromatosis","volume":"22","author":"Gulati","year":"2014","journal-title":"Cardiol. Rev."},{"issue":"10","key":"10.1016\/j.ijcard.2021.07.060_bb0120","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1540-8175.2009.00956.x","article-title":"Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis?","volume":"26","author":"Shizukuda","year":"2009","journal-title":"Echocardiography (Mount Kisco, N.Y.)"},{"issue":"4","key":"10.1016\/j.ijcard.2021.07.060_bb0125","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s12265-016-9704-2","article-title":"Iron overload or oxidative stress? Insight into a mechanism of early cardiac manifestations of asymptomatic hereditary hemochromatosis subjects with C282Y homozygosity","volume":"9","author":"Shizukuda","year":"2016","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.ijcard.2021.07.060_bb0130","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/0002-8703(94)90609-2","article-title":"Myocardial involvement in primary hemochromatosis demonstrated by magnetic resonance imaging","volume":"128","author":"Waxman","year":"1994","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2021.07.060_bb0135","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1081\/JCMR-200065632","article-title":"Early diagnosis of hemochromatosis-related cardiomyopathy with magnetic resonance imaging","volume":"7","author":"Ptaszek","year":"2005","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"3","key":"10.1016\/j.ijcard.2021.07.060_bb0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa073286","article-title":"Iron-overload-related disease in HFE hereditary hemochromatosis","volume":"358","author":"Allen","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2021.07.060_bb0145","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/01.CIR.100.12.1268","article-title":"Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women","volume":"100","author":"Roest","year":"1999","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ijcard.2021.07.060_bb0150","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000338825","article-title":"Determinants of pulmonary hypertension in patients with Beta-thalassemia major and normal ventricular function","volume":"128","author":"Vlahos","year":"2012","journal-title":"Acta Haematol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321012055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321012055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:54:21Z","timestamp":1759092861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527321012055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":30,"alternative-id":["S0167527321012055"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.07.060","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular manifestations in hospitalized patients with hemochromatosis in the United States","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.07.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}