{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:31:55Z","timestamp":1783585915718,"version":"3.55.0"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ijcard.2021.08.020","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T07:40:19Z","timestamp":1629272419000},"page":"84-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Impact of cyanosis on ventilatory responses during stair climb exercise in Eisenmenger syndrome and idiopathic pulmonary arterial hypertension"],"prefix":"10.1016","volume":"341","author":[{"given":"Chinthaka B.","family":"Samaranayake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Siewers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Kempny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gatzoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Hopkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Wort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2021.08.020_bb0005","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1152\/jappl.1988.64.1.234","article-title":"Control of ventilation during exercise in patients with central venous-to-systemic arterial shunts","volume":"64","author":"Sietsema","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0010","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1161\/CIRCULATIONAHA.105.594218","article-title":"Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival","volume":"113","author":"Dimopoulos","year":"2006","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0015","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/eurheartj\/ehr461","article-title":"Reference values for exercise limitations among adults with congenital heart disease. Relation to activities of daily life--single Centre experience and review of published data","volume":"33","author":"Kempny","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0020","series-title":"Principles of Exercise Testing and Interpretation","author":"Wasserman","year":"2012"},{"key":"10.1016\/j.ijcard.2021.08.020_bb0025","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3389\/fphys.2020.00964","article-title":"Pulmonary vascular disease and cardiopulmonary exercise testing","volume":"11","author":"Laveneziana","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0030","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1513\/AnnalsATS.201610-788FR","article-title":"Cardiopulmonary exercise testing in pulmonary hypertension","volume":"14","author":"Weatherald","year":"2017","journal-title":"Ann Am Thorac Soc."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0035","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/01.CIR.1.3.404","article-title":"Circulatory adjustments to the hypoxemia of congenital heart disease of the cyanotic type","volume":"1","author":"Burchell","year":"1950","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0040","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/S0735-1097(97)00360-4","article-title":"Effects of chronic hypoxemia on chemosensitivity in patients with univentricular heart","volume":"30","author":"Chua","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0045","first-page":"183","article-title":"Effects of anticipation, prior-exercise, and breathing frequency to ventilatory response during step exercise: a preliminary study","volume":"21","author":"Fukuba","year":"1992","journal-title":"J. Hum. Ergol."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0050","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.neuron.2015.08.001","article-title":"Neural control of breathing and CO2 homeostasis","volume":"87","author":"Guyenet","year":"2015","journal-title":"Neuron."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0055","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1183\/09031936.03.00045402","article-title":"The pattern and timing of breathing during incremental exercise: a normative study","volume":"21","author":"Neder","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0060","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.rmed.2015.05.022","article-title":"Lung function in pulmonary hypertension","volume":"109","author":"Low","year":"2015","journal-title":"Respir. Med."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0065","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1183\/09031936.00223611","article-title":"Dynamic respiratory mechanics and exertional dyspnoea in pulmonary arterial hypertension","volume":"41","author":"Laveneziana","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijcard.2021.08.020_bb0070","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/CIRCULATIONAHA.112.126755","article-title":"Abnormal lung function in adults with congenital heart disease: prevalence, relation to cardiac anatomy, and association with survival","volume":"127","author":"Alonso-Gonzalez","year":"2013","journal-title":"Circulation."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321012304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321012304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:53:43Z","timestamp":1759092823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527321012304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":14,"alternative-id":["S0167527321012304"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.08.020","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of cyanosis on ventilatory responses during stair climb exercise in Eisenmenger syndrome and idiopathic pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}