{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:27:09Z","timestamp":1791296829745,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL078825"],"award-info":[{"award-number":["P01 HL078825"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ijcard.2021.08.021","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T23:00:32Z","timestamp":1628895632000},"page":"68-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Exercise-induced late preconditioning in mice is triggered by eNOS-dependent generation of nitric oxide and activation of PKC\u03b5 and is mediated by increased iNOS activity"],"prefix":"10.1016","volume":"340","author":[{"given":"Yiru","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Slezak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Tomlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2021.08.021_bb0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00788866","article-title":"The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview","volume":"91","author":"Bolli","year":"1996","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0010","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0015","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1161\/01.RES.87.11.972","article-title":"The late phase of preconditioning","volume":"87","author":"Bolli","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1749-6632.2002.tb04053.x","article-title":"Role of nitric oxide in myocardial preconditioning","volume":"962","author":"Dawn","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0025","doi-asserted-by":"crossref","first-page":"H2251","DOI":"10.1152\/ajpheart.00341.2005","article-title":"Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS","volume":"289","author":"Guo","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0030","doi-asserted-by":"crossref","first-page":"H2534","DOI":"10.1152\/ajpheart.00209.2002","article-title":"COX-2-derived prostacyclin mediates opioid-induced late phase of preconditioning in isolated rat hearts","volume":"283","author":"Shinmura","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0035","doi-asserted-by":"crossref","first-page":"H1278","DOI":"10.1152\/ajpheart.2001.280.3.H1278","article-title":"Adenosine-induced late preconditioning in mouse hearts: role of p38 MAP kinase and mitochondrial K(ATP) channels","volume":"280","author":"Zhao","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0040","first-page":"H1324","article-title":"Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits","volume":"273","author":"Maldonado","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0045","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/00005344-199705000-00011","article-title":"Time course of delayed myocardial protection after transient adenosine A1-receptor activation in the rabbit","volume":"29","author":"Baxter","year":"1997","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/01.RES.83.1.73","article-title":"Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism","volume":"83","author":"Takano","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0055","first-page":"H2488","article-title":"Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway","volume":"277","author":"Banerjee","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0060","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/01.RES.84.5.587","article-title":"Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning","volume":"84","author":"Ping","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0065","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/hc3201.092218","article-title":"Nitroglycerin induces late preconditioning against myocardial infarction in conscious rabbits despite development of nitrate tolerance","volume":"104","author":"Hill","year":"2001","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0070","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.lfs.2003.10.036","article-title":"COX-2 and iNOS in opioid-induced delayed cardioprotection in the intact rat","volume":"75","author":"Patel","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0075","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00395-006-0594-3","article-title":"Differential activation of mitogen-activated protein kinases in ischemic and nitroglycerin-induced preconditioning","volume":"101","author":"Iliodromitis","year":"2006","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s003950050101","article-title":"The nitric oxide hypothesis of late preconditioning [editorial; see comments]","volume":"93","author":"Bolli","year":"1998","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0085","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0002-9149(98)00918-7","article-title":"Exercise-induced myocardial ischemia triggers the early phase of preconditioning but not the late phase","volume":"83","author":"Tomai","year":"1999","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0090","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1161\/01.CIR.103.24.2935","article-title":"Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty","volume":"103","author":"Leesar","year":"2001","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0095","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1006\/jmcc.2001.1462","article-title":"Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research","volume":"33","author":"Bolli","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0100","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1161\/hc5001.100039","article-title":"Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 2","volume":"104","author":"Kloner","year":"2001","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0105","first-page":"H320","article-title":"Enhanced postischemic myocardial recovery following exercise induction of HSP 72","volume":"269","author":"Locke","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0110","first-page":"H1098","article-title":"Acute exercise can improve cardioprotection without increasing heat shock protein content","volume":"276","author":"Taylor","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0115","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1084\/jem.189.11.1699","article-title":"Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation","volume":"189","author":"Yamashita","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0120","doi-asserted-by":"crossref","first-page":"H1346","DOI":"10.1152\/ajpheart.2001.281.3.H1346","article-title":"Short-term exercise training can improve myocardial tolerance to I\/R without elevation in heat shock proteins","volume":"281","author":"Hamilton","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0125","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/heart.85.3.331","article-title":"Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism","volume":"85","author":"Yamashita","year":"2001","journal-title":"Heart."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0130","first-page":"A41","article-title":"Exercise-induced late preconditioning is triggered by generation of nitric oxide","volume":"33","author":"Guo","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0135","article-title":"Nitric oxide plays a dual role in exercise-induced late preconditioning","volume":"104","author":"Guo","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2021.08.021_bb0140","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1152\/jappl.2001.91.5.2205","article-title":"Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat","volume":"91","author":"Demirel","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0145","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0008-6363(02)00334-6","article-title":"Exercise induces early and late myocardial preconditioning in dogs","volume":"55","author":"Domenech","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0150","doi-asserted-by":"crossref","first-page":"H2051","DOI":"10.1152\/ajpheart.01102.2006","article-title":"Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS","volume":"292","author":"Akita","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0155","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/CIRCULATIONAHA.107.689471","article-title":"Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C epsilon p44\/42 mitogen-activated protein kinase pSer-signal transducers and activators of transcription1\/3 pathway","volume":"116","author":"Xuan","year":"2007","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0160","doi-asserted-by":"crossref","first-page":"H2360","DOI":"10.1152\/ajpheart.2000.279.5.H2360","article-title":"Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits","volume":"279","author":"Xuan","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0165","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1050-1738(02)00230-X","article-title":"Role of the JAK-STAT pathway in protection against myocardial ischemia\/reperfusion injury","volume":"13","author":"Bolli","year":"2003","journal-title":"Trends Cardiovasc Med."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0170","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/01.RES.84.5.587","article-title":"Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning","volume":"84","author":"Ping","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0175","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/01.RES.81.3.404","article-title":"Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity","volume":"81","author":"Ping","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0180","first-page":"H1468","article-title":"PKC-dependent activation of p44\/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits","volume":"276","author":"Ping","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0185","first-page":"173","article-title":"Exercise increases systemic nitric oxide production in men","volume":"1","author":"Bode-Boger","year":"1994","journal-title":"J. Cardiovasc. Risk"},{"key":"10.1016\/j.ijcard.2021.08.021_bb0190","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1152\/jappl.1997.82.3.760","article-title":"Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans","volume":"82","author":"Jungersten","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0195","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.CIR.98.4.369","article-title":"Limb blood flow during exercise is dependent on nitric oxide","volume":"98","author":"Maxwell","year":"1998","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0200","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1161\/01.CIR.98.24.2709","article-title":"Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure","volume":"98","author":"Hambrecht","year":"1998","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0205","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2000-13308","article-title":"Influence of an acute exercise on neutrophil and platelet adhesion, nitric oxide plasma metabolites in inactive and active subjects","volume":"21","author":"Cuzzolin","year":"2000","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0210","first-page":"H1346","article-title":"Impaired aerobic capacity in hypercholesterolemic mice: partial reversal by exercise training","volume":"276","author":"Niebauer","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0215","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1161\/01.CIR.99.22.2951","article-title":"Exercise improves flow-mediated vasodilatation of skeletal muscle arteries in rats with chronic heart failure. Role of nitric oxide, prostanoids, and oxidant stress","volume":"99","author":"Varin","year":"1999","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0220","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1152\/jappl.1994.76.5.2177","article-title":"Effects of exercise on macrophage activation for antitumor cytotoxicity","volume":"76","author":"Woods","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0225","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/jappl.1999.87.1.465","article-title":"Aging and acute exercise enhance free radical generation in rat skeletal muscle","volume":"87","author":"Bejma","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0230","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","article-title":"Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide","volume":"87","author":"Beckman","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0235","doi-asserted-by":"crossref","first-page":"H975","DOI":"10.1152\/ajpheart.01208.2003","article-title":"Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning","volume":"287","author":"Lennon","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0240","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1073\/pnas.96.20.11507","article-title":"The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene","volume":"96","author":"Guo","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0245","first-page":"H1595","article-title":"A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice","volume":"273","author":"Fewell","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0047-6374(99)00014-7","article-title":"Effects of 6 months of moderate aerobic exercise training on immune function in the elderly","volume":"109","author":"Woods","year":"1999","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0255","first-page":"R1354","article-title":"Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training","volume":"287","author":"Murphy","year":"2004","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0260","doi-asserted-by":"crossref","first-page":"E405","DOI":"10.1152\/ajpendo.00385.2005","article-title":"Energy state of the liver during short-term and exhaustive exercise in C57BL\/6J mice","volume":"290","author":"Camacho","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0265","first-page":"R482","article-title":"Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice","volume":"276","author":"Lu","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0270","doi-asserted-by":"crossref","first-page":"H1649","DOI":"10.1152\/ajpheart.00971.2003","article-title":"Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo","volume":"286","author":"Guo","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0275","first-page":"H1375","article-title":"Demonstration of an early and a late phase of ischemic preconditioning in mice","volume":"275","author":"Guo","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0280","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1172\/JCI0213200","article-title":"Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection","volume":"109","author":"Ping","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0285","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1073\/pnas.161283798","article-title":"An essential role of the JAK-STAT pathway in ischemic preconditioning","volume":"98","author":"Xuan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0290","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1634\/stemcells.2007-0715","article-title":"Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction","volume":"26","author":"Dawn","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijcard.2021.08.021_bb0295","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.88.5.520","article-title":"A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms","volume":"88","author":"Takano","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0300","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/01.RES.79.3.424","article-title":"Time course of late preconditioning against myocardial stunning in conscious pigs","volume":"79","author":"Tang","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0305","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s003950070024","article-title":"Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice","volume":"95","author":"Guo","year":"2000","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0310","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-201X.2003.01131.x","article-title":"Dose-dependent effects of acute exercise on PKC levels in rat heart: is PKC the heart\u2019s prophylactic?","volume":"178","author":"Carson","year":"2003","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0315","first-page":"1","article-title":"Physical inactivity as a risk factor for coronary heart disease: a WHO and international society and Federation of Cardiology position statement","volume":"72","author":"Bijnen","year":"1994","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0320","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF02892287","article-title":"Exercise and its role in the prevention and rehabilitation of cardiovascular disease","volume":"19","author":"Miller","year":"1997","journal-title":"Ann. Behav. Med."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0325","doi-asserted-by":"crossref","unstructured":"Considine RV. Invited editorial on \"Acute and chronic effects of exercise on leptin levels in humans\". J Appl Physiol (1985). 1997;83:3\u20134.doi:https:\/\/doi.org\/10.1152\/jappl.1997.83.1.3.","DOI":"10.1152\/jappl.1997.83.1.3"},{"key":"10.1016\/j.ijcard.2021.08.021_bb0330","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1161\/01.CIR.86.1.340","volume":"86","author":"Fletcher","year":"1992","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0335","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1440-1681.1995.tb01982.x","article-title":"Mechanisms for reduction of cardiovascular risk by regular exercise","volume":"22","author":"Jennings","year":"1995","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0340","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJM199302253280803","article-title":"Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men [see comments]","volume":"328","author":"Sandvik","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0345","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pu.08.050187.001345","article-title":"Physical activity and the incidence of coronary heart disease","volume":"8","author":"Powell","year":"1987","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.ijcard.2021.08.021_bb0350","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1161\/01.CIR.80.2.234","article-title":"An overview of randomized trials of rehabilitation with exercise after myocardial infarction","volume":"80","author":"O\u2019Connor","year":"1989","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0355","first-page":"H1053","article-title":"Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease","volume":"272","author":"Desai","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0360","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/cvr\/28.7.1014","article-title":"\u201cNormothermic range\u201d temperature affects myocardial infarct size","volume":"28","author":"Chien","year":"1994","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0365","first-page":"R366","article-title":"Effects of moderate exercise and oat beta-glucan on innate immune function and susceptibility to respiratory infection","volume":"286","author":"Davis","year":"2004","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0370","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1749-6632.2002.tb04062.x","article-title":"Regulation of endothelial nitric oxide synthase activity and gene expression","volume":"962","author":"Wu","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ijcard.2021.08.021_bb0375","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.abb.2007.02.004","article-title":"Role of mitochondria in exercise-induced oxidative stress in skeletal muscle from hyperthyroid rats","volume":"463","author":"Venditti","year":"2007","journal-title":"Arch. Biochem. Biophys."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321012316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321012316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:53:39Z","timestamp":1759092819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527321012316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":75,"alternative-id":["S0167527321012316"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.08.021","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise-induced late preconditioning in mice is triggered by eNOS-dependent generation of nitric oxide and activation of PKC\u03b5 and is mediated by increased iNOS activity","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}