{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:12:18Z","timestamp":1790183538397,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012141","name":"University Hospitals Bristol NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ijcard.2021.08.037","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T11:09:30Z","timestamp":1629976170000},"page":"180-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Cardiovascular magnetic resonance characterisation of anthracycline cardiotoxicity in adults with normal left ventricular ejection fraction"],"prefix":"10.1016","volume":"343","author":[{"given":"Iwan","family":"Harries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bostjan","family":"Berlot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"ffrench-Constant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"De Garate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baritussio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Biglino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Plana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bucciarelli-Ducci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ijcard.2021.08.037_bb0005","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.echo.2014.07.012","article-title":"Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"27","author":"Plana","year":"2014","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"36","key":"10.1016\/j.ijcard.2021.08.037_bb0010","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: the Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur. Heart J."},{"issue":"8","key":"10.1016\/j.ijcard.2021.08.037_bb0015","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1200\/JCO.2016.70.5400","article-title":"Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline","volume":"35","author":"Armenian","year":"2017","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.ijcard.2021.08.037_bb0020","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2017.06.046","article-title":"Geometry as a confounder when assessing ventricular systolic function: comparison between ejection fraction and strain","volume":"70","author":"Stokke","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.037_bb0025","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1532-429X-15-48","article-title":"Diffuse myocardial fibrosis by T1-mapping in children with subclinical anthracycline cardiotoxicity: relationship to exercise capacity, cumulative dose and remodeling","volume":"15","author":"Tham","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"6","key":"10.1016\/j.ijcard.2021.08.037_bb0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIRCIMAGING.113.000798","article-title":"Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy","volume":"6","author":"Toro-Salazar","year":"2013","journal-title":"Circ. Cardiovasc Imaging."},{"issue":"4","key":"10.1016\/j.ijcard.2021.08.037_bb0035","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.118.008453","article-title":"Cardiac magnetic resonance T1 mapping in adolescent and young adult survivors of childhood cancers","volume":"12","author":"Tong","year":"2019","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"8","key":"10.1016\/j.ijcard.2021.08.037_bb0040","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.115.004325","article-title":"Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors","volume":"9","author":"Jordan","year":"2016","journal-title":"Circ. Cardiovasc Imaging."},{"issue":"5","key":"10.1016\/j.ijcard.2021.08.037_bb0045","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.amjcard.2012.11.022","article-title":"Myocardial extracellular volume by cardiac magnetic resonance imaging in patients treated with anthracycline-based chemotherapy","volume":"111","author":"Neilan","year":"2013","journal-title":"Am. J. Cardiol."},{"issue":"8","key":"10.1016\/j.ijcard.2021.08.037_bb0050","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jcmg.2018.05.012","article-title":"Anthracycline therapy is associated with cardiomyocyte atrophy and preclinical manifestations of heart disease","volume":"11","author":"Ferreira de Souza","year":"2018","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2021.08.037_bb0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijcard.2018.03.025","article-title":"Late characterisation of cardiac effects following anthracycline and trastuzumab treatment in breast cancer patients","volume":"261","author":"Kimball","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2021.08.037_bb0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12968-015-0111-7","article-title":"Normal values for cardiovascular magnetic resonance in adults and children","volume":"17","author":"Kawel-Boehm","year":"2015","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"1","key":"10.1016\/j.ijcard.2021.08.037_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12968-020-00607-1","article-title":"Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update","volume":"22","author":"Kramer","year":"2020","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"1","key":"10.1016\/j.ijcard.2021.08.037_bb0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12968-020-00610-6","article-title":"Standardized image interpretation and post-processing in cardiovascular magnetic resonance - 2020 update\u202f: Society for Cardiovascular Magnetic Resonance (SCMR): Board of Trustees Task Force on Standardized Post-Processing","volume":"22","author":"Schulz-Menger","year":"2020","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"1","key":"10.1016\/j.ijcard.2021.08.037_bb0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mrm.20110","article-title":"Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart","volume":"52","author":"Messroghli","year":"2004","journal-title":"Magn. Reson. Med."},{"issue":"2","key":"10.1016\/j.ijcard.2021.08.037_bb0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.109.930636","article-title":"Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans","volume":"122","author":"Flett","year":"2010","journal-title":"Circulation."},{"issue":"10","key":"10.1016\/j.ijcard.2021.08.037_bb0085","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/ehjci\/jes102","article-title":"Diffuse myocardial fibrosis in severe aortic stenosis: an equilibrium contrast cardiovascular magnetic resonance study","volume":"13","author":"Flett","year":"2012","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"11","key":"10.1016\/j.ijcard.2021.08.037_bb0090","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.amjcard.2012.07.040","article-title":"Left ventricular mass in patients with a cardiomyopathy after treatment with anthracyclines","volume":"110","author":"Neilan","year":"2012","journal-title":"Am. J. Cardiol."},{"issue":"23","key":"10.1016\/j.ijcard.2021.08.037_bb0095","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1200\/JCO.2011.40.3584","article-title":"Screening adult survivors of childhood cancer for cardiomyopathy: comparison of echocardiography and cardiac magnetic resonance imaging","volume":"30","author":"Armstrong","year":"2012","journal-title":"J. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.ijcard.2021.08.037_bb0100","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004560","article-title":"Left ventricular mass change after anthracycline chemotherapy","volume":"11","author":"Jordan","year":"2018","journal-title":"Circ. Heart Fail."},{"issue":"3\u20134","key":"10.1016\/j.ijcard.2021.08.037_bb0105","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000360238","article-title":"Cardiotoxicity and cardioprotection in childhood cancer","volume":"132","author":"Lipshultz","year":"2014","journal-title":"Acta Haematol."},{"issue":"3","key":"10.1016\/j.ijcard.2021.08.037_bb0110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/CIRCIMAGING.112.000192","article-title":"Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume","volume":"6","author":"Miller","year":"2013","journal-title":"Circ. Cardiovasc Imaging."},{"issue":"1","key":"10.1016\/j.ijcard.2021.08.037_bb0115","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jcmg.2017.04.006","article-title":"Native T1 mapping and extracellular volume mapping for the assessment of diffuse myocardial fibrosis in dilated cardiomyopathy","volume":"11","author":"Nakamori","year":"2018","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2021.08.037_bb0120","article-title":"Can quantitative CMR tissue characterization adequately identify cardiotoxicity during chemotherapy?: Impact of temporal and observer variability","author":"Altaha","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"12","key":"10.1016\/j.ijcard.2021.08.037_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009535","article-title":"Myocardial extracellular volume fraction adds prognostic information beyond myocardial replacement fibrosis","volume":"12","author":"Yang","year":"2019","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"25 Pt A","key":"10.1016\/j.ijcard.2021.08.037_bb0130","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1016\/j.jacc.2014.01.073","article-title":"Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review","volume":"63","author":"Thavendiranathan","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.ijcard.2021.08.037_bb0135","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jcmg.2012.11.017","article-title":"Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease","volume":"6","author":"Drafts","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"4","key":"10.1016\/j.ijcard.2021.08.037_bb0140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/COC.0b013e31829e19be","article-title":"Cardiac magnetic resonance imaging for the assessment of the myocardium after doxorubicin-based chemotherapy","volume":"38","author":"Lunning","year":"2015","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.ijcard.2021.08.037_bb0145","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijcard.2018.03.041","article-title":"Myocardial strain imaging by cardiac magnetic resonance for detection of subclinical myocardial dysfunction in breast cancer patients receiving trastuzumab and chemotherapy","volume":"261","author":"Ong","year":"2018","journal-title":"Int. J. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcard.2021.08.037_bb0150","doi-asserted-by":"crossref","first-page":"270","DOI":"10.5603\/CJ.a2016.0023","article-title":"Cardiac magnetic resonance imaging-based myocardial strain study for evaluation of cardiotoxicity in breast cancer patients treated with trastuzumab: A pilot study to evaluate the feasibility of the method","volume":"23","author":"Nakano","year":"2016","journal-title":"Cardiol. J."},{"issue":"9","key":"10.1016\/j.ijcard.2021.08.037_bb0155","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.jcmg.2019.01.044","article-title":"2- and 3-Dimensional Myocardial Strain in Cardiac Health and Disease","volume":"12","author":"Voigt","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"8","key":"10.1016\/j.ijcard.2021.08.037_bb0160","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/ehjci\/jex033","article-title":"2D and 3D strain for detection of subclinical anthracycline cardiotoxicity in breast cancer patients: a balance with feasibility","volume":"18","author":"Santoro","year":"2017","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"23","key":"10.1016\/j.ijcard.2021.08.037_bb0165","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/CIRCULATIONAHA.117.027740","article-title":"Association of feature-tracking cardiac magnetic resonance imaging left ventricular global longitudinal strain with all-cause mortality in patients with reduced left ventricular ejection fraction","volume":"135","author":"Romano","year":"2017","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ijcard.2021.08.037_bb0170","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jacc.2018.11.046","article-title":"Serial magnetic resonance imaging to identify early stages of anthracycline-induced cardiotoxicity","volume":"73","author":"Gal\u00e1n-Arriola","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.ijcard.2021.08.037_bb0175","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.jcmg.2020.04.004","article-title":"Cardiac magnetic resonance feature tracking global longitudinal strain and prognosis after heart transplantation","volume":"13","author":"Shenoy","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"4","key":"10.1016\/j.ijcard.2021.08.037_bb0180","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jcmg.2019.10.004","article-title":"Feature-tracking global longitudinal strain predicts mortality in patients with preserved ejection fraction: a multicenter study","volume":"13","author":"Romano","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"10","key":"10.1016\/j.ijcard.2021.08.037_bb0185","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.jcmg.2017.10.024","article-title":"Feature-tracking global longitudinal strain predicts death in a multicenter population of patients with ischemic and nonischemic dilated cardiomyopathy incremental to ejection fraction and late gadolinium enhancement","volume":"11","author":"Romano","year":"2018","journal-title":"JACC Cardiovasc. Imaging"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321013036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527321013036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:55:40Z","timestamp":1759092940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527321013036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":37,"alternative-id":["S0167527321013036"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.08.037","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular magnetic resonance characterisation of anthracycline cardiotoxicity in adults with normal left ventricular ejection fraction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2021.08.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}