{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:28:21Z","timestamp":1777850901957,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01622"],"award-info":[{"award-number":["PI16\/01622"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["B2017\/BMD-3676"],"award-info":[{"award-number":["B2017\/BMD-3676"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ijcard.2022.01.050","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T04:00:32Z","timestamp":1643601632000},"page":"125-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Exploring the potential relationship between collagen cross-linking and impaired myocardial relaxation in Marfan syndrome: An observational study using serum biomarkers"],"prefix":"10.1016","volume":"352","author":[{"given":"Eusebio","family":"Garc\u00eda-Izquierdo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Mingo-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Olivo-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Mo\u00f1ivas-Palomero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Rivas-Lasarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Mart\u00edn-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Rosado-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio J.","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Miguel","family":"Redondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Rodr\u00edguez-Pascual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Segovia-Cubero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Forteza-Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2022.01.050_bb0005","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/echo.13517","article-title":"The role of advanced echocardiography and cardiovascular magnetic resonance in the assessment of myocardial function in marfan syndrome-an update","volume":"34","author":"Kiotsekoglou","year":"2017","journal-title":"Echocardiography"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijcard.2005.10.010","article-title":"Primary impairment of left ventricular function in marfan syndrome","volume":"112","author":"De Backer","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/clc.3","article-title":"Tissue doppler imaging identifies myocardial dysfunction in adults with marfan syndrome","volume":"30","author":"Rybczynski","year":"2007","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0020","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/ejechocard\/jep110","article-title":"Biventricular and atrial diastolic function assessment using conventional echocardiography and tissue-doppler imaging in adults with marfan syndrome","volume":"10","author":"Kiotsekoglou","year":"2009","journal-title":"Eur. J. Echocardiogr."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0025","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.echo.2011.09.004","article-title":"Biventricular performance in patients with marfan syndrome without significant valvular disease: comparison to normal subjects and longitudinal follow-up","volume":"24","author":"Scherptong","year":"2011","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0030","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/ehjci\/jeu219","article-title":"Normal values and clinical relevance of left atrial myocardial function analysed by speckle-tracking echocardiography: multicentre study","volume":"16","author":"Morris","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0035","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10554-018-1425-y","article-title":"Peak left atrial strain as a single measure for the non-invasive assessment of left ventricular filling pressures","volume":"35","author":"Singh","year":"2019","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0040","doi-asserted-by":"crossref","DOI":"10.1007\/s10554-021-02247-7","article-title":"Left atrial strain in the assessment of diastolic function: providing new insights into primary myocardial dysfunction in marfan syndrome","author":"Garc\u00eda-Izquierdo","year":"2021","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jacc.2015.10.063","article-title":"Myocardial collagen cross-linking is associated with heart failure hospitalization in patients with hypertensive heart failure","volume":"67","author":"L\u00f3pez","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.yjmcc.2015.05.008","article-title":"Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in marfan syndrome","volume":"85","author":"Busnadiego","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0060","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the european Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0065","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/ehjci\/jew082","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"17","author":"Nagueh","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjci\/jeu184","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry task force to standardize deformation imaging","volume":"16","author":"Voigt","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0075","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI\/ASE\/Industry task force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/cvr\/cvv214","article-title":"Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction","volume":"109","author":"Gonz\u00e1lez-Santamar\u00eda","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0085","doi-asserted-by":"crossref","first-page":"E1483","DOI":"10.3390\/cells8121483","article-title":"The role of lysyl oxidase enzymes in cardiac function and remodeling","volume":"8","author":"Rodr\u00edguez","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0090","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jacc.2010.10.024","article-title":"Diastolic tissue doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction","volume":"57","author":"Kasner","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0095","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/HYPERTENSIONAHA.112.196113","article-title":"Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase","volume":"60","author":"L\u00f3pez","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2022.01.050_bb0100","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/HJH.0000000000001258","article-title":"Phenotyping of myocardial fibrosis in hypertensive patients with heart failure. Influence on clinical outcome","volume":"35","author":"Ravassa","year":"2017","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0105","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.jacc.2018.12.074","article-title":"Combination of circulating type I collagen-related biomarkers is associated with atrial fibrillation","volume":"73","author":"Ravassa","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0110","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1073\/pnas.0910312107","article-title":"Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in marfan syndrome","volume":"107","author":"Lindeman","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0115","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.jacc.2019.01.059","article-title":"Left atrial structure and function, and left ventricular diastolic dysfunction: JACC state-of-the-art review","volume":"73","author":"Thomas","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0120","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10741-019-09889-9","article-title":"Left atrial strain in left ventricular diastolic dysfunction: have we finally found the missing piece of the puzzle?","volume":"25","author":"Mandoli","year":"2020","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ijcard.2022.01.050_bb0125","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.echo.2020.03.021","article-title":"Evaluation of left atrial size and function: relevance for clinical practice","volume":"33","author":"Thomas","year":"2020","journal-title":"J. Am. Soc. Echocardiogr."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527322001760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527322001760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:13:38Z","timestamp":1777500818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527322001760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":25,"alternative-id":["S0167527322001760"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2022.01.050","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the potential relationship between collagen cross-linking and impaired myocardial relaxation in Marfan syndrome: An observational study using serum biomarkers","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2022.01.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}