{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:35:28Z","timestamp":1775885728534,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ijcard.2022.02.021","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T11:09:23Z","timestamp":1645182563000},"page":"54-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Serum Klotho and pulse pressure; insight from NHANES"],"prefix":"10.1016","volume":"355","author":[{"given":"Mutaz","family":"Alkalbani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurang","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Lagbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehan","family":"Qayyum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2022.02.021_bb0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0010","article-title":"Shedding of klotho: functional implications in chronic kidney disease and associated vascular disease","volume":"7","author":"Saar-Kovrov","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0015","article-title":"Klotho deficiency-induced arterial calcification involves osteoblastic transition of VSMCs and activation of BMP signaling","author":"Lin","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0020","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00109-019-01841-6","article-title":"Autophagy plays a critical role in klotho gene deficiency-induced arterial stiffening and hypertension","volume":"97","author":"Chen","year":"2019","journal-title":"J. Mol. Med. Berl. Ger."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0025","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/HYPERTENSIONAHA.116.07709","article-title":"Activation of SIRT1 attenuates klotho deficiency\u2013induced arterial stiffness and hypertension by enhancing AMP-activated protein kinase activity","volume":"68","author":"Gao","year":"2016","journal-title":"Hypertension."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0030","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/HJH.0b013e328353e501","article-title":"Defining vascular aging and cardiovascular risk","volume":"30","author":"Laurent","year":"2012","journal-title":"J. Hypertens."},{"issue":"127","key":"10.1016\/j.ijcard.2022.02.021_bb0035","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1055\/s-2002-35356","article-title":"Risk evaluation and therapeutical implications of pulse pressure in primary arterial hypertension","volume":"1946","author":"B\u00f6nner","year":"2002","journal-title":"Dtsch. Med. Wochenschr."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0040","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jacc.2015.10.084","article-title":"Pulse pressure and risk for cardiovascular events in patients with atherothrombosis","volume":"67","author":"Selvaraj","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/HYPERTENSIONAHA.115.06825","article-title":"Antiaging gene klotho deficiency promoted high-fat diet\u2013induced arterial stiffening via inactivation of AMP-activated protein kinase","volume":"67","author":"Lin","year":"2016","journal-title":"Hypertension."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0050","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1159\/000492245","article-title":"Circulating \u03b1-klotho levels in hemodialysis patients and their relationship to atherosclerosis","volume":"43","author":"Yu","year":"2018","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0060","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"CKD-EPI (chronic kidney disease epidemiology collaboration), a new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11517-008-0359-2","article-title":"The arterial Windkessel","volume":"47","author":"Westerhof","year":"2009","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00877747","article-title":"Elastic properties and Windkessel function of the human aorta","volume":"9","author":"Belz","year":"1995","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0075","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/CIRCULATIONAHA.111.053405","article-title":"Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23","volume":"125","author":"Lim","year":"2012","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0080","doi-asserted-by":"crossref","first-page":"640","DOI":"10.7326\/0003-4819-152-10-201005180-00004","article-title":"The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study","volume":"152","author":"Parker","year":"2010","journal-title":"Ann. Intern. Med."},{"issue":"131","key":"10.1016\/j.ijcard.2022.02.021_bb0085","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1042\/CS20171242","article-title":"Soluble levels and endogenous vascular gene expression of KLOTHO are related to inflammation in human atherosclerotic disease","volume":"1979","author":"Mart\u00edn-N\u00fa\u00f1ez","year":"2017","journal-title":"Clin. Sci. Lond. Engl."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0090","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jjcc.2020.11.014","article-title":"Serum soluble klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease","volume":"77","author":"Koga","year":"2021","journal-title":"J. Cardiol."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0095","first-page":"34","article-title":"Reduced klotho is associated with the presence and severity of coronary artery disease","volume":"100","author":"Navarro-Gonz\u00e1lez","year":"2014","journal-title":"Heart Br. Card. Soc."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0100","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.1998.8943","article-title":"Klotho protein protects against endothelial dysfunction","volume":"248","author":"Saito","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijcard.2022.02.021_bb0105","doi-asserted-by":"crossref","first-page":"38029","DOI":"10.1074\/jbc.M509039200","article-title":"Regulation of oxidative stress by the anti-aging hormone klotho","volume":"280","author":"Yamamoto","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752732200256X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752732200256X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:56:33Z","timestamp":1759092993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016752732200256X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":20,"alternative-id":["S016752732200256X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2022.02.021","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Klotho and pulse pressure; insight from NHANES","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2022.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}