{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:18:02Z","timestamp":1782015482543,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.ijcard.2022.12.005","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T13:12:16Z","timestamp":1670245936000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Prognostic importance of biomarkers associated with haemostatic, vascular and endothelial disturbances in acute coronary syndrome patients in relation to kidney function"],"prefix":"10.1016","volume":"373","author":[{"given":"Josefin","family":"M\u00f6rtberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Salzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Lundwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Edfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan N.","family":"Wall\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Jernberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Erlinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus","family":"Andell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai M.","family":"Eggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Hjort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Lundman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Tornvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Rezeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Marko-Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Lindahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Spaak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.ijcard.2022.12.005_bb0005","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0010","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ahj.2009.01.009","article-title":"Chronic kidney disease and dipstick proteinuria are risk factors for stent thrombosis in patients with myocardial infarction","volume":"157","author":"Lambert","year":"2009","journal-title":"Am. Heart J."},{"issue":"2","key":"10.1016\/j.ijcard.2022.12.005_bb0015","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1053\/j.ajkd.2003.10.037","article-title":"Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study","volume":"43","author":"Landray","year":"2004","journal-title":"Am. J. Kidney Dis."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0020","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/ajh\/hpz193","article-title":"Arterial stiffness in hypertension and function of large arteries","volume":"33","author":"Zhang","year":"2020","journal-title":"Am. J. Hypertens."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0025","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/bcp.12014","article-title":"Regression of vascular calcification in chronic kidney disease - feasible or fantasy? a review of the clinical evidence","volume":"76","author":"Leonard","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"12","key":"10.1016\/j.ijcard.2022.12.005_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003478","article-title":"Long-term health outcomes of people with reduced kidney function in the UK: a modelling study using population health data","volume":"17","author":"Schlackow","year":"2020","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.ijcard.2022.12.005_bb0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/ndt\/gft209","article-title":"Haemostasis in chronic kidney disease","volume":"29","author":"Lutz","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0040","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MBC.0000000000000462","article-title":"Increased fibrin formation and impaired fibrinolytic capacity in severe chronic kidney disease","volume":"27","author":"Mortberg","year":"2016","journal-title":"Blood Coagul. Fibrinolys. Int. J. Haemost. Thromb."},{"issue":"7","key":"10.1016\/j.ijcard.2022.12.005_bb0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/MBC.0000000000000765","article-title":"Hemostasis based on a novel \u2018two-path unifying theory\u2019 and classification of hemostatic disorders","volume":"29","author":"Chang","year":"2018","journal-title":"Blood Coagul. Fibrinolys. Int. J. Haemost. Thromb."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0050","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000441364","article-title":"Paricalcitol, microvascular and endothelial function in non-diabetic chronic kidney disease: a randomized trial","volume":"42","author":"Lundwall","year":"2015","journal-title":"Am. J. Nephrol."},{"issue":"9","key":"10.1016\/j.ijcard.2022.12.005_bb0055","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/acs.jproteome.7b00235","article-title":"Quantitation of 87 proteins by nLC-MRM\/MS in human plasma: workflow for large-scale analysis of biobank samples","volume":"16","author":"Rezeli","year":"2017","journal-title":"J. Proteome Res."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2022.12.005_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clinbiochem.2021.09.001","article-title":"Differences in biomarker concentrations and predictions of long-term outcome in patients with ST-elevation and non-ST-elevation myocardial infarction","volume":"98","author":"Hjort","year":"2021","journal-title":"Clin. Biochem."},{"issue":"20","key":"10.1016\/j.ijcard.2022.12.005_bb0070","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/hrt.2010.198804","article-title":"The Swedish Web-system for enhancement and development of evidence-based care in heart disease evaluated according to recommended therapies (SWEDEHEART)","volume":"96","author":"Jernberg","year":"2010","journal-title":"Heart"},{"issue":"9","key":"10.1016\/j.ijcard.2022.12.005_bb0075","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.ijcard.2022.12.005_bb0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12882-019-1261-x","article-title":"Increased concentrations of platelet- and endothelial-derived microparticles in patients with myocardial infarction and reduced renal function- a descriptive study","volume":"20","author":"Mortberg","year":"2019","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.ijcard.2022.12.005_bb0085","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jprot.2013.05.016","article-title":"Development of an MRM assay panel with application to biobank samples from patients with myocardial infarction","volume":"87","author":"Rezeli","year":"2013","journal-title":"J. Proteome"},{"issue":"1","key":"10.1016\/j.ijcard.2022.12.005_bb0090","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.atherosclerosis.2015.07.023","article-title":"Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis","volume":"242","author":"Lind","year":"2015","journal-title":"Atherosclerosis."},{"issue":"7","key":"10.1016\/j.ijcard.2022.12.005_bb0095","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.amjcard.2015.01.027","article-title":"Prognostic significance of adrenomedullin in patients with heart failure and with myocardial infarction","volume":"115","author":"Yuyun","year":"2015","journal-title":"Am. J. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcard.2022.12.005_bb0100","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.pharmthera.2006.02.004","article-title":"Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders","volume":"111","author":"Ishimitsu","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.ijcard.2022.12.005_bb0105","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4239\/wjd.v5.i3.364","article-title":"Adrenomedullin and diabetes","volume":"5","author":"Wong","year":"2014","journal-title":"World J. Diabetes"},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0110","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ki.2008.560","article-title":"Pro-A-type natriuretic peptide and pro-adrenomedullin predict progression of chronic kidney disease: the MMKD Study","volume":"75","author":"Dieplinger","year":"2009","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0115","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.ijcard.2013.05.005","article-title":"Associations of mid-regional pro-adrenomedullin levels to cardiovascular and metabolic abnormalities, and mortality in an elderly population from the community","volume":"168","author":"Eggers","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0120","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1177\/147323001204000435","article-title":"Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus","volume":"40","author":"Peckov\u00e1","year":"2012","journal-title":"J. Int. Med. Res."},{"issue":"3","key":"10.1016\/j.ijcard.2022.12.005_bb0125","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1160\/th15-06-0511","article-title":"Soluble urokinase plasminogen activator receptor and incidence of venous thromboembolism","volume":"115","author":"Engstrom","year":"2016","journal-title":"Thromb. Haemost."},{"issue":"Suppl. 1","key":"10.1016\/j.ijcard.2022.12.005_bb0130","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.ijantimicag.2015.10.011","article-title":"suPAR: The unspecific marker for disease presence, severity and prognosis","volume":"46","author":"Eugen-Olsen","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"12","key":"10.1016\/j.ijcard.2022.12.005_bb0135","first-page":"1462","article-title":"SuPAR predicts cardiovascular events and mortality in patients with asymptomatic aortic stenosis","volume":"32","author":"Hodges","year":"2016","journal-title":"Canad. J. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2022.12.005_bb0145","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.numecd.2011.12.006","article-title":"Renin as a biomarker of cardiovascular disease in clinical practice","volume":"22","author":"Volpe","year":"2012","journal-title":"Nutrit. Metabol. Cardiovasc. Diseas."},{"issue":"5","key":"10.1016\/j.ijcard.2022.12.005_bb0150","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014294","article-title":"Blood coagulation system in patients with chronic kidney disease: a prospective observational study","volume":"7","author":"Huang","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.ijcard.2022.12.005_bb0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1477-9560-7-11","article-title":"Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarction","volume":"7","author":"Steppich","year":"2009","journal-title":"Thromb. J."},{"issue":"3","key":"10.1016\/j.ijcard.2022.12.005_bb0160","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1538-7836.2007.02372.x","article-title":"Prognostic value of plasma tissue factor and tissue factor pathway inhibitor for cardiovascular death in patients with coronary artery disease: the AtheroGene study","volume":"5","author":"Morange","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.ijcard.2022.12.005_bb0165","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/MBC.0b013e32832da16d","article-title":"Tissue factor\/its pathway inhibitor system and kynurenines in chronic kidney disease patients on conservative treatment","volume":"20","author":"Pawlak","year":"2009","journal-title":"Blood Coagul. Fibrinolys. Int. J. Haemost. Thromb."},{"key":"10.1016\/j.ijcard.2022.12.005_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2015.11.083","article-title":"Arterial stiffness, atherosclerosis and cardiovascular risk: pathophysiologic mechanisms and emerging clinical indications","volume":"77","author":"Palombo","year":"2016","journal-title":"Vasc. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.ijcard.2022.12.005_bb0175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2005.12.030","article-title":"Circulating markers of endothelial function in cardiovascular disease","volume":"368","author":"Constans","year":"2006","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"10.1016\/j.ijcard.2022.12.005_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2016.03.003","article-title":"Targeting thrombin long-term after an acute coronary syndrome: opportunities and challenges","volume":"81","author":"De Caterina","year":"2016","journal-title":"Vasc. Pharmacol."},{"issue":"8","key":"10.1016\/j.ijcard.2022.12.005_bb0185","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.tips.2017.05.001","article-title":"Targeting PAR1: Now What?","volume":"38","author":"Flaumenhaft","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"11","key":"10.1016\/j.ijcard.2022.12.005_bb0190","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jacc.2009.10.043","article-title":"Impact of chronic kidney disease on platelet function profiles in diabetes mellitus patients with coronary artery disease taking dual antiplatelet therapy","volume":"55","author":"Angiolillo","year":"2010","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527322018769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527322018769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:59:54Z","timestamp":1759093194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527322018769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":37,"alternative-id":["S0167527322018769"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2022.12.005","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic importance of biomarkers associated with haemostatic, vascular and endothelial disturbances in acute coronary syndrome patients in relation to kidney function","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2022.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}