{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:49:01Z","timestamp":1792986541058,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ijcard.2023.05.007","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T17:15:54Z","timestamp":1683652554000},"page":"59-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Hypotension at heart failure discharge: Should it be a limiting factor for drug titration?"],"prefix":"10.1016","volume":"386","author":[{"given":"Maria","family":"Melendo-Viu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dobarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"March\u00e1n L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Manuel","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Raposeiras-Roub\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Abu-Assi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Cardero-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"P\u00e9rez-Exp\u00f3sito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Cesp\u00f3n Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Parada Barcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Barreiro P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"\u00cd\u00f1iguez Romo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"36","key":"10.1016\/j.ijcard.2023.05.007_bb0005","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.ijcard.2023.05.007_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm9072089","article-title":"Estimated population prevalence of heart failure with reduced ejection fraction in Spain, according to DAPA-HF study criteria","volume":"9","author":"Camps-Vilar\u00f3","year":"2020","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.ijcard.2023.05.007_bb0015","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jacc.2020.11.022","volume":"77","author":"Maddox","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.ijcard.2023.05.007_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchf.2020.10.014","article-title":"Treatment of HF in an era of multiple therapies: statement from the HF Collaboratory","volume":"9","author":"Bhatt","year":"2021","journal-title":"JACC Heart Fail."},{"issue":"6","key":"10.1016\/j.ijcard.2023.05.007_bb0025","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1161\/CIRCHEARTFAILURE.112.970889","article-title":"Heart failure patients with low blood pressure","volume":"5","author":"Parwani","year":"2012","journal-title":"Circ. Heart Fail."},{"issue":"8","key":"10.1016\/j.ijcard.2023.05.007_bb0030","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/ejhf.1835","article-title":"Management of low blood pressure in ambulatory heart failure with reduced ejection fraction patients","volume":"22","author":"Cautela","year":"2020","journal-title":"Eur. J. Heart Fail."},{"issue":"15","key":"10.1016\/j.ijcard.2023.05.007_bb0035","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008789","article-title":"Reasons for guideline nonadherence at heart failure discharge","volume":"7","author":"Gilstrap","year":"2018","journal-title":"J. Am. Heart Assoc.: Cardiovasc. Cerebrovasc. Dis."},{"issue":"3","key":"10.1016\/j.ijcard.2023.05.007_bb0040","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jchf.2019.09.011","article-title":"Mineralocorticoid receptor antagonists, blood pressure, and outcomes in heart failure with reduced ejection fraction","volume":"8","author":"Serenelli","year":"2020","journal-title":"JACC Heart Fail."},{"issue":"1","key":"10.1016\/j.ijcard.2023.05.007_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchf.2018.06.011","article-title":"Initiation, continuation, switching, and withdrawal of heart failure medical therapies during hospitalization","volume":"7","author":"Bhagat","year":"2019","journal-title":"JACC Heart Fail."},{"issue":"5","key":"10.1016\/j.ijcard.2023.05.007_bb0050","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ejhf.510","article-title":"Physicians\u2019 adherence to guideline-recommended medications in heart failure with reduced ejection fraction: data from the QUALIFY global survey","volume":"18","author":"Komajda","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"4","key":"10.1016\/j.ijcard.2023.05.007_bb0055","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jchf.2018.11.011","article-title":"Target doses of heart failure medical therapy and blood pressure: insights from the CHAMP-HF registry","volume":"7","author":"Peri-Okonny","year":"2019","journal-title":"JACC Heart Fail."},{"issue":"5","key":"10.1016\/j.ijcard.2023.05.007_bb0060","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/jama.2019.9811","article-title":"Association of Office and Ambulatory Blood Pressure with Mortality and cardiovascular outcomes","volume":"322","author":"Staessen","year":"2019","journal-title":"JAMA."},{"issue":"24","key":"10.1016\/j.ijcard.2023.05.007_bb0065","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1001\/jama.2016.7050","article-title":"Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged \u226575 years: a randomized clinical trial","volume":"315","author":"Williamson","year":"2016","journal-title":"JAMA."},{"issue":"6","key":"10.1016\/j.ijcard.2023.05.007_bb0070","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/CIRCHEARTFAILURE.113.000872","article-title":"Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF","volume":"7","author":"Patel","year":"2014","journal-title":"Circ. Heart Fail."},{"issue":"24","key":"10.1016\/j.ijcard.2023.05.007_bb0075","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1016\/j.jacc.2019.04.022","article-title":"Systolic blood pressure and outcomes in patients with heart failure with reduced ejection fraction","volume":"73","author":"Arundel","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcard.2023.05.007_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007347","article-title":"Synergistic impact of systolic blood pressure and perfusion status on mortality in acute heart failure","volume":"14","author":"Rossello","year":"2021","journal-title":"Circ. Heart Fail."},{"issue":"10","key":"10.1016\/j.ijcard.2023.05.007_bb0085","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/ejhf.890","article-title":"Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC heart failure long-term registry","volume":"19","author":"Chioncel","year":"2017","journal-title":"Eur. J. Heart Fail."},{"issue":"1","key":"10.1016\/j.ijcard.2023.05.007_bb0090","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ahj.2005.03.009","article-title":"The association between blood pressure and mortality in patients with heart failure","volume":"151","author":"Lee","year":"2006","journal-title":"Am. Heart J."},{"issue":"7","key":"10.1016\/j.ijcard.2023.05.007_bb0095","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/ejhf.805","article-title":"Prognostic value of long-term blood pressure changes in patients with chronic heart failure","volume":"19","author":"Schmid","year":"2017","journal-title":"Eur. J. Heart Fail."},{"issue":"21","key":"10.1016\/j.ijcard.2023.05.007_bb0100","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.ijcard.2023.05.007_bb0105","first-page":"132","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"JJ M","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2023.05.007_bb0110","series-title":"Up-titrating heart failure medicines-a practical guide","author":"MEDICINEWISE NEWS","year":"2021"},{"key":"10.1016\/j.ijcard.2023.05.007_bb0115","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006667","article-title":"Treatment differences in chronic heart failure patients with reduced ejection fraction according to blood pressure","author":"Veenis","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ijcard.2023.05.007_bb0120","doi-asserted-by":"crossref","DOI":"10.15420\/ecr.2021.22","article-title":"Women and diabetes: preventing heart disease in a new era of therapies","volume":"16","author":"Galati","year":"2021","journal-title":"Eur. Cardiol."},{"issue":"12","key":"10.1016\/j.ijcard.2023.05.007_bb0125","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.repc.2021.07.009","article-title":"Optimization of heart failure with reduced ejection fraction prognosis-modifying drugs: a 2021 heart failure expert consensus paper","volume":"40","author":"Silva-Cardoso","year":"2021","journal-title":"Rev. Port. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2023.05.007_bb0130","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1161\/01.CIR.89.4.1632","article-title":"Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators","volume":"89","author":"Bristow","year":"1994","journal-title":"Circulation."},{"issue":"4","key":"10.1016\/j.ijcard.2023.05.007_bb0135","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12435","article-title":"The reverse remodeling response to sacubitril\/valsartan therapy in heart failure with reduced ejection fraction","volume":"36","author":"Martens","year":"2018","journal-title":"Cardiovasc. Ther."},{"issue":"3","key":"10.1016\/j.ijcard.2023.05.007_bb0140","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/ehf2.13285","article-title":"Reverse remodelling by sacubitril\/valsartan predicts the prognosis in heart failure with reduced ejection fraction","volume":"8","author":"Moon","year":"2021","journal-title":"ESC Heart Fail."},{"issue":"6","key":"10.1016\/j.ijcard.2023.05.007_bb0145","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMoa1812851","article-title":"Angiotensin-Neprilysin inhibition in acute decompensated heart failure","volume":"380","author":"Velazquez","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.ijcard.2023.05.007_bb0150","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/ejhf.1498","article-title":"Initiation of sacubitril\/valsartan in haemodynamically stabilised heart failure patients in hospital or early after discharge: primary results of the randomised TRANSITION study","volume":"21","author":"Wachter","year":"2019","journal-title":"Eur. J. Heart Fail."},{"issue":"2","key":"10.1016\/j.ijcard.2023.05.007_bb0155","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007034","article-title":"Efficacy and safety of Sacubitril\/valsartan in high-risk patients in the PIONEER-HF trial","volume":"14","author":"Berg","year":"2021","journal-title":"Circ. Heart Fail."},{"issue":"9","key":"10.1016\/j.ijcard.2023.05.007_bb0160","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/ejhf.548","article-title":"Initiating sacubitril\/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens","volume":"18","author":"Senni","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"10367","key":"10.1016\/j.ijcard.2023.05.007_bb0165","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/S0140-6736(22)02076-1","article-title":"Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial","volume":"400","author":"Mebazaa","year":"2022","journal-title":"Lancet."},{"issue":"22","key":"10.1016\/j.ijcard.2023.05.007_bb0170","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijcard.2023.05.007_bb0175","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jjcc.2019.03.010","article-title":"Sacubitril\/valsartan in heart failure with reduced ejection fraction patients: real world experience on advanced chronic kidney disease, hypotension, and dose escalation","volume":"74","author":"Chang","year":"2019","journal-title":"J. Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323006587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323006587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T21:02:43Z","timestamp":1759093363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527323006587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":35,"alternative-id":["S0167527323006587"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.05.007","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypotension at heart failure discharge: Should it be a limiting factor for drug titration?","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}