{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:19:46Z","timestamp":1770045586946,"version":"3.49.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ijcard.2023.131123","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T03:22:30Z","timestamp":1686885750000},"page":"131123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["16\u03b1-OHE1, a novel oestrogen metabolite, attenuates dysfunction of left ventricle contractility via regulation of autophagy after myocardial ischemia and reperfusion"],"prefix":"10.1016","volume":"388","author":[{"given":"Ze-Yuan","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Min","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Li","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Qing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ijcard.2023.131123_bb0005","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: from basic science to clinical bedside","volume":"16","author":"Frank","year":"2012","journal-title":"Semin. Cardiothorac. Vasc. Anesth."},{"issue":"9","key":"10.1016\/j.ijcard.2023.131123_bb0010","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.118.039262","article-title":"S100a8\/a9 signaling causes mitochondrial dysfunction and cardiomyocyte death in response to ischemic\/reperfusion injury","volume":"140","author":"Li","year":"2019","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2023.131123_bb0015","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ijbiomac.2018.11.190","article-title":"Involvement of Nrf2 in myocardial ischemia and reperfusion injury","volume":"125","author":"Shen","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.ijcard.2023.131123_bb0020","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131123_bb0025","doi-asserted-by":"crossref","first-page":"H1553","DOI":"10.1152\/ajpheart.00158.2018","article-title":"Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury","volume":"315","author":"Toldo","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"14","key":"10.1016\/j.ijcard.2023.131123_bb0030","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","article-title":"Evolving therapies for myocardial ischemia\/reperfusion injury","volume":"65","author":"Ib\u00e1\u00f1ez","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0035","first-page":"209","article-title":"Clinical manifestations and basic mechanisms of myocardial ischemia\/reperfusion injury","volume":"30","author":"Yang","year":"2018","journal-title":"Ci Ji Yi Xue Za Zhi."},{"key":"10.1016\/j.ijcard.2023.131123_bb0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2018.01.024","article-title":"ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection","volume":"117","author":"Cadenas","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijcard.2023.131123_bb0045","doi-asserted-by":"crossref","first-page":"2950503","DOI":"10.1155\/2016\/2950503","article-title":"Mitochondria-targeted antioxidants: future perspectives in kidney ischemia reperfusion injury","volume":"2016","author":"Kezic","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131123_bb0050","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2023.131123_bb0055","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.biopha.2018.03.078","article-title":"Estrogen: the necessary evil for human health, and ways to tame it","volume":"102","author":"Patel","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0060","doi-asserted-by":"crossref","first-page":"H820","DOI":"10.1152\/ajpheart.00734.2019","article-title":"Estrogen and calcium handling proteins: new discoveries and mechanisms in cardiovascular diseases","volume":"318","author":"Jiao","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2023.131123_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119190","article-title":"Decreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female rats","volume":"271","author":"Bozdogan","year":"2021","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131123_bb0070","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/CIRCULATIONAHA.120.051775","article-title":"Premature menopause, clonal hematopoiesis, and coronary artery disease in postmenopausal women","volume":"143","author":"Honigberg","year":"2021","journal-title":"Circulation."},{"issue":"14","key":"10.1016\/j.ijcard.2023.131123_bb0075","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1161\/CIRCULATIONAHA.119.041306","article-title":"Isoflavone intake and the risk of coronary heart disease in US men and women: results from 3 prospective cohort studies","volume":"141","author":"Ma","year":"2020","journal-title":"Circulation."},{"issue":"Pt A","key":"10.1016\/j.ijcard.2023.131123_bb0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.steroids.2015.02.015","article-title":"Epidemiologic studies of estrogen metabolism and breast cancer","volume":"99","author":"Ziegler","year":"2015","journal-title":"Steroids."},{"issue":"20","key":"10.1016\/j.ijcard.2023.131123_bb0085","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1021\/ac070494j","article-title":"Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry","volume":"79","author":"Xu","year":"2007","journal-title":"Anal. Chem."},{"issue":"15","key":"10.1016\/j.ijcard.2023.131123_bb0090","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3390\/cells11152262","article-title":"Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators","volume":"11","author":"G\u00f3mez-Virgilio","year":"2022","journal-title":"Cells."},{"issue":"11","key":"10.1016\/j.ijcard.2023.131123_bb0095","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","article-title":"Autophagy and Mitophagy in cardiovascular disease","volume":"120","author":"Bravo-San Pedro","year":"2017","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131123_bb0100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13293-019-0256-4","article-title":"Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice","volume":"10","author":"Ghimire","year":"2019","journal-title":"Biol. Sex Differ."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131123_bb0105","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3892\/etm.2017.4343","article-title":"LFG-500, a newly synthesized flavonoid, induces apoptosis in human ovarian carcinoma SKOV3 cells with involvement of the reactive oxygen species-mitochondria pathway","volume":"13","author":"Yin","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"20","key":"10.1016\/j.ijcard.2023.131123_bb0110","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016590","article-title":"Identification of key small non-coding MicroRNAs controlling pacemaker mechanisms in the human sinus node","volume":"9","author":"Petkova","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0115","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics."},{"key":"10.1016\/j.ijcard.2023.131123_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131123_bb0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131123_bb0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ijcard.2023.131123_bb0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.mcn.2018.02.004","article-title":"Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway","volume":"88","author":"Majd","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ijcard.2023.131123_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.615250","article-title":"17\u03b2-estradiol induces Mitophagy upregulation to protect chondrocytes via the SIRT1-mediated AMPK\/mTOR signaling pathway","volume":"11","author":"Mei","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0145","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.apsb.2019.10.003","article-title":"Targeting autophagy-related protein kinases for potential therapeutic purpose","volume":"10","author":"Xiang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"15","key":"10.1016\/j.ijcard.2023.131123_bb0150","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes Ferroptosis by directly blocking system xc- activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131123_bb0155","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.ijcard.2023.131123_bb0160","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles","volume":"16","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131123_bb0165","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/15548627.2020.1728096","article-title":"Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease","volume":"17","author":"Franco-Iborra","year":"2021","journal-title":"Autophagy."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131123_bb0170","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12943-021-01423-6","article-title":"Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers","volume":"20","author":"Raudenska","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ijcard.2023.131123_bb0175","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nature08455","article-title":"Discovery of Atg5\/Atg7-independent alternative macroautophagy","volume":"461","author":"Nishida","year":"2009","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131123_bb0180","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1074\/jbc.M109.070037","article-title":"Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death","volume":"285","author":"Kobayashi","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.ijcard.2023.131123_bb0185","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1080\/09553002.2022.2055799","article-title":"Autophagy regulates X-ray radiation-induced premature senescence through STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells","volume":"98","author":"Tian","year":"2022","journal-title":"Int. J. Radiat. Biol."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0190","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1164\/rccm.202109-2168OC","article-title":"Autophagy is impaired in fetal Hypoplastic lungs and rescued by Administration of Amniotic Fluid Stem Cell Extracellular Vesicles","volume":"206","author":"Khalaj","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijcard.2023.131123_bb0195","doi-asserted-by":"crossref","first-page":"38091","DOI":"10.1038\/srep38091","article-title":"The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijcard.2023.131123_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119228","article-title":"AM1241 alleviates myocardial ischemia-reperfusion injury in rats by enhancing Pink1\/Parkin-mediated autophagy","volume":"272","author":"Liu","year":"2021","journal-title":"Life Sci."},{"issue":"14","key":"10.1016\/j.ijcard.2023.131123_bb0205","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1093\/cvr\/cvx183","article-title":"Cardiac troponins: from myocardial infarction to chronic disease","volume":"113","author":"Park","year":"2017","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0210","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1515\/cclm-2020-1433","article-title":"Clinical relevance of biological variation of cardiac troponins","volume":"59","author":"Clerico","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.ijcard.2023.131123_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/VHRM.S166157","article-title":"Biomarkers in acute myocardial infarction: current perspectives","volume":"15","author":"Aydin","year":"2019","journal-title":"Vasc. Health Risk Manag."},{"issue":"19","key":"10.1016\/j.ijcard.2023.131123_bb0220","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.jacc.2017.09.024","article-title":"A test in context: D-dimer","volume":"70","author":"Weitz","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9\u201310","key":"10.1016\/j.ijcard.2023.131123_bb0225","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1007\/s00216-013-7542-5","article-title":"LC-MS\/MS in the routine clinical laboratory: has its time come?","volume":"406","author":"Leung","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0230","doi-asserted-by":"crossref","first-page":"H1514","DOI":"10.1152\/ajpheart.01283.2007","article-title":"The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy","volume":"294","author":"Bell","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131123_bb0235","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1124\/jpet.105.090803","article-title":"Gender differences in cardioprotection against ischemia\/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling","volume":"315","author":"Bae","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131123_bb0240","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/15548627.2020.1752511","article-title":"Sex differences in autophagy-mediated diseases: toward precision medicine","volume":"17","author":"Shang","year":"2021","journal-title":"Autophagy."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131123_bb0245","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/15548627.2018.1520549","article-title":"How does estrogen work on autophagy?","volume":"15","author":"Xiang","year":"2019","journal-title":"Autophagy."},{"key":"10.1016\/j.ijcard.2023.131123_bb0250","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jare.2020.08.010","article-title":"Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor \u03b1-mediated autophagy","volume":"28","author":"Meng","year":"2020","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131123_bb0255","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/1074248410370327","article-title":"Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury","volume":"15","author":"Dong","year":"2010","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.ijcard.2023.131123_bb0260","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1002\/jcp.28125","article-title":"mTOR and Beclin1: two key autophagy-related molecules and their roles in myocardial ischemia\/reperfusion injury","volume":"234","author":"Shi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131123_bb0265","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00424-013-1247-7","article-title":"Estrogen and estrogen receptors in cardiovascular oxidative stress","volume":"465","author":"Arias-Loza","year":"2013","journal-title":"Pflugers Arch."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131123_bb0270","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bbrc.2018.05.004","article-title":"Vaspin alleviates myocardial ischaemia\/reperfusion injury via activating autophagic flux and restoring lysosomal function","volume":"503","author":"Yang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131123_bb0275","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20194030","article-title":"Dexmedetomidine postconditioning suppresses myocardial ischemia\/reperfusion injury by activating the SIRT1\/mTOR axis","volume":"40","author":"Zhang","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ijcard.2023.131123_bb0280","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.biopha.2018.06.088","article-title":"Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy","volume":"105","author":"Qing","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131123_bb0285","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1159\/000491474","article-title":"Melatonin attenuates myocardial ischemia\/reperfusion injury by inhibiting autophagy via an AMPK\/mTOR signaling pathway","volume":"47","author":"Chen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131123_bb0290","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/00015385.2021.2024701","article-title":"AMPK\/mTOR-mediated therapeutic effect of metformin on myocardial ischaemia reperfusion injury in diabetic rat","volume":"78","author":"Zhang","year":"2023","journal-title":"Acta Cardiol."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131123_bb0295","first-page":"349","article-title":"Ginsenoside Rg1 protects cardiomyocytes from hypoxia-induced injury through the PI3K\/AKT\/mTOR pathway","volume":"73","author":"Qin","year":"2018","journal-title":"Pharmazie."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0300","first-page":"1917","article-title":"Inhibition of autophagy via activation of PI3K\/Akt\/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia\/reperfusion injury","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0305","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41401-019-0301-1","article-title":"Exogenous NADPH ameliorates myocardial ischemia-reperfusion injury in rats through activating AMPK\/mTOR pathway","volume":"41","author":"Zhu","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.ijcard.2023.131123_bb0310","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.cell.2022.04.013","article-title":"mTOR substrate phosphorylation in growth control","volume":"185","author":"Battaglioni","year":"2022","journal-title":"Cell."},{"key":"10.1016\/j.ijcard.2023.131123_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106298","article-title":"Bisphenol a promotes autophagy in ovarian granulosa cells by inducing AMPK\/mTOR\/ULK1 signalling pathway","volume":"147","author":"Lin","year":"2021","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131123_bb0320","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.canlet.2004.10.007","article-title":"Cytochrome P450-mediated metabolism of estrogens and its regulation in human","volume":"227","author":"Tsuchiya","year":"2005","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131123_bb0325","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2174\/138920008784220664","article-title":"Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4","volume":"9","author":"Zhou","year":"2008","journal-title":"Curr. Drug Metab."},{"issue":"8","key":"10.1016\/j.ijcard.2023.131123_bb0330","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.hrthm.2022.04.012","article-title":"Molecular and functional characterization of the mouse intrinsic cardiac nervous system","volume":"19","author":"Lizot","year":"2022","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2023.131123_bb0335","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/635023","article-title":"The ovariectomized rat as a model for studying alveolar bone loss in postmenopausal women","volume":"2015","author":"Johnston","year":"2015","journal-title":"Biomed. Res. Int."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323009300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323009300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T21:01:56Z","timestamp":1759093316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527323009300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":67,"alternative-id":["S0167527323009300"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131123","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"16\u03b1-OHE1, a novel oestrogen metabolite, attenuates dysfunction of left ventricle contractility via regulation of autophagy after myocardial ischemia and reperfusion","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"131123"}}