{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:47:30Z","timestamp":1789984050136,"version":"4.0.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ijcard.2023.131128","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T13:00:18Z","timestamp":1687611618000},"page":"131128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Inhibition of miR-195-3p protects against cardiac dysfunction and fibrosis after myocardial infarction"],"prefix":"10.1016","volume":"387","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-7907","authenticated-orcid":false,"given":"Abdlay","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaixiao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4332-3013","authenticated-orcid":false,"given":"Genshan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2023.131128_bb0005","first-page":"3","article-title":"Epidemiology global public health burden of heart failure","author":"Savarese","year":"2017","journal-title":"CRF J."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131128_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2013.12.028","article-title":"The annual global economic burden of heart failure","volume":"171","author":"Cook","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0015","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The extracellular matrix in ischemic and nonischemic heart failure","volume":"125","author":"Frangogiannis","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2023.131128_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2011.11.007","article-title":"The pathophysiology of heart failure","volume":"21","author":"Kemp","year":"2012","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0025","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00023.2006","article-title":"Cardiac fibroblasts: Friend or foe?","volume":"291","author":"Baudino","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131128_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling-concepts and clinical implications: A consensus paper from an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131128_bb0035","article-title":"Collagen remodeling after myocardial infarction in the rat heart","volume":"147","author":"Cleutjens","year":"1995","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2009.12.074","article-title":"Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease","volume":"56","author":"Azevedo","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131128_bb0045","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.108.838367","article-title":"Influence of myocardial fibrosis on left ventricular diastolic function","volume":"2","author":"Moreo","year":"2009","journal-title":"Circ. Cardiovasc. Imag."},{"issue":"2 I","key":"10.1016\/j.ijcard.2023.131128_bb0050","article-title":"Stimulation of collagen production by transforming growth factor-\u03b21 during differentiation of cardiac fibroblasts to myofibroblasts","volume":"39","author":"Petrov","year":"2002","journal-title":"Hypertension."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.20548","article-title":"Scar myofibroblasts of the infarcted rat heart express natriuretic peptides","volume":"207","author":"Calderone","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0060","series-title":"Current Drug Targets - Cardiovascular and Haematological Disorders","article-title":"Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways","volume":"Vol. 3","author":"Jugdutt","year":"2003"},{"key":"10.1016\/j.ijcard.2023.131128_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: The fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131128_bb0070","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00132.2011","article-title":"The extracellular matrix: An active or passive player in fibrosis?","volume":"301","author":"Wight","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-\u03b2 signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2023.131128_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardiores.2005.01.011","article-title":"Healing after myocardial infarction","volume":"66","author":"Ertl","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2023.131128_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2016.12.029","article-title":"Aldosterone pathway blockade to prevent atrial fibrillation: a systematic review and meta-analysis","volume":"231","author":"Neefs","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2016.09.945","article-title":"MicroRNAs in cardiovascular disease","volume":"68","author":"Barwari","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0095","first-page":"1","article-title":"Role of selected miRNAs as diagnostic and prognostic biomarkers in cardiovascular diseases, including coronary artery disease, myocardial infarction and atherosclerosis","volume":"8","author":"Mir","year":"2021","journal-title":"J. Cardiovasc. Develop. Dis. MDPI AG"},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0100","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201106-1093OC","article-title":"Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension","volume":"185","author":"Pullamsetti","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"48","key":"10.1016\/j.ijcard.2023.131128_bb0105","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0608791103","article-title":"A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure","volume":"103","author":"van Rooij","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131128_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2011.12.024","article-title":"Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT","volume":"24","author":"Ghosh","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ijcard.2023.131128_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2021.11.014","article-title":"MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression","volume":"355","author":"Wang","year":"2022","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010201","article-title":"Cardiosomal microRNAs are essential in post-infarction myofibroblast phenoconversion","volume":"21","author":"Morelli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0130","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.111.244442","article-title":"Inhibition of miR-15 protects against cardiac ischemic injury","volume":"110","author":"Hullinger","year":"2012","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131128_bb0135","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.115.018174","article-title":"MiR-125b Is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis","volume":"133","author":"Nagpal","year":"2016","journal-title":"Circulation."},{"issue":"12","key":"10.1016\/j.ijcard.2023.131128_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/cbin.10655","article-title":"MiR-154 directly suppresses DKK2 to activate Wnt signaling pathway and enhance activation of cardiac fibroblasts","volume":"40","author":"Sun","year":"2016","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ijcard.2023.131128_bb0145","first-page":"7","article-title":"MiR-144-3p enhances cardiac fibrosis after myocardial infarction by targeting PTEN","author":"Yuan","year":"2019","journal-title":"Front. Cell. Dev. Biol."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0150","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00487.2018","article-title":"Bmi1 promotes cardiac fibrosis in ischemia-induced heart failure via the pten-pi3k\/akt-mtor signaling pathway","volume":"316","author":"Yang","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131128_bb0155","doi-asserted-by":"crossref","DOI":"10.1159\/000438594","article-title":"Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation","volume":"37","author":"Teng","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijcard.2023.131128_bb0160","first-page":"44","article-title":"Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1\/IL-11 signaling","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0165","doi-asserted-by":"crossref","DOI":"10.1159\/000489185","article-title":"MicroRNA-223 regulates cardiac fibrosis after myocardial infarction by targeting RASA1","volume":"46","author":"Liu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09530-1","article-title":"Therapeutic role of miR-19a\/19b in cardiac regeneration and protection from myocardial infarction","volume":"10","author":"Gao","year":"2019","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.ijcard.2023.131128_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.119.314898","article-title":"Nuclear miR-320 mediates diabetes-induced cardiac dysfunction by activating transcription of fatty acid metabolic genes to cause lipotoxicity in the heart","volume":"125","author":"Li","year":"2019","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.ijcard.2023.131128_bb0180","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.14534","article-title":"Telmisartan cardioprotects from the ischaemic\/hypoxic damage through a miR-1-dependent pathway","volume":"23","author":"Trotta","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"55","key":"10.1016\/j.ijcard.2023.131128_bb0185","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.21831","article-title":"Soluble epoxide hydrolase inhibitors, t-AUCB, regulated microRNA-1 and its target genes in myocardial infarction mice","volume":"8","author":"Gui","year":"2017","journal-title":"Oncotarget."},{"issue":"43","key":"10.1016\/j.ijcard.2023.131128_bb0190","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M109.027896","article-title":"MicroRNA expression signature and the role of MicroRNA-21 in the early phase of acute myocardial infarction","volume":"284","author":"Dong","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131128_bb0195","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12118","article-title":"Cardioprotective effect of MicroRNA-21 in murine myocardial infarction","volume":"33","author":"Gu","year":"2015","journal-title":"Cardiovasc. Ther."},{"issue":"14","key":"10.1016\/j.ijcard.2023.131128_bb0200","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.111.030932","article-title":"Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure","volume":"124","author":"Montgomery","year":"2011","journal-title":"Circulation."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0205","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.110.958975","article-title":"Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage","volume":"4","author":"Kuwabara","year":"2011","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.ijcard.2023.131128_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2018.01.019","article-title":"Down-regulation of miR-133a\/b in patients with myocardial infarction correlates with the presence of ventricular fibrillation","volume":"99","author":"Bo\u0161tjan\u010di\u010d","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijcard.2023.131128_bb0215","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10529-019-02685-3","article-title":"MiR-499 inhibited hypoxia\/reoxygenation induced cardiomyocytes injury by targeting SOX6","volume":"41","author":"Shi","year":"2019","journal-title":"Biotechnol. Lett."},{"issue":"24","key":"10.1016\/j.ijcard.2023.131128_bb0220","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.9597","article-title":"MiR-499-5p protects cardiomyocytes against ischaemic injury via anti-apoptosis by targeting PDCD4","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0225","article-title":"Mir-195 promotes myocardial fibrosis in MI rats via targeting TGF-pi\/Smad","volume":"34","author":"Wang","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.ijcard.2023.131128_bb0230","first-page":"12","article-title":"MicroRNA-195-5p downregulation inhibits endothelial mesenchymal transition and myocardial fibrosis in diabetic cardiomyopathy by targeting Smad7 and inhibiting transforming growth factor Beta 1-smads-snail pathway","author":"Ding","year":"2021","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0235","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvr145","article-title":"MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1","volume":"92","author":"Zhu","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0240","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/cvr\/cvu184","article-title":"The microRNA-15 family inhibits the TGF\u03b2-pathway in the heart","volume":"104","author":"Tijsen","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2023.131128_bb0245","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/cvr\/cvp014","article-title":"Cardiac regulation by phosphoinositide 3-kinases and PTEN","volume":"82","author":"Oudit","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"22","key":"10.1016\/j.ijcard.2023.131128_bb0250","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-05-1522","article-title":"Transforming growth factor-\u03b2 activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2","volume":"65","author":"Wilkes","year":"2005","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131128_bb0255","doi-asserted-by":"crossref","DOI":"10.1006\/jmcc.2000.1129","article-title":"Induction of cardiac fibrosis by aldosterone","volume":"32","author":"Lijnen","year":"2000","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0260","doi-asserted-by":"crossref","first-page":"154277","DOI":"10.1016\/j.phymed.2022.154277","article-title":"Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways","volume":"104","author":"Chen","year":"2022","journal-title":"Phytomedicine."},{"key":"10.1016\/j.ijcard.2023.131128_bb0265","first-page":"9","article-title":"MiR-208b\/miR-21 promotes the progression of cardiac fibrosis through the activation of the TGF-\u03b21\/Smad-3 signaling pathway: an in vitro and in vivo study","author":"Zhang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0270","doi-asserted-by":"crossref","DOI":"10.3892\/or.2016.5023","article-title":"TGF-\u03b21 regulating MIR-205\/MIR-195 expression affects the TGF-\u03b2 signal pathway by respectively targeting SMAD2\/SMAD7","volume":"36","author":"Duan","year":"2016","journal-title":"Oncol. Rep."},{"issue":"8","key":"10.1016\/j.ijcard.2023.131128_bb0275","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-015-3622-8","article-title":"Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL\/6 mice","volume":"58","author":"Zheng","year":"2015","journal-title":"Diabetologia."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131128_bb0280","doi-asserted-by":"crossref","DOI":"10.1038\/ncb1258","article-title":"Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance","volume":"7","author":"MacKeigan","year":"2005","journal-title":"Nat. Cell Biol."},{"issue":"40","key":"10.1016\/j.ijcard.2023.131128_bb0285","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0604320103","article-title":"Genome-wide functional analysis of human cell-cycle regulators","volume":"103","author":"Mukherji","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0290","doi-asserted-by":"crossref","DOI":"10.1038\/nm.4062","article-title":"PTEN opposes negative selection and enables oncogenic transformation of pre-B cells","volume":"22","author":"Shojaee","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijcard.2023.131128_bb0295","series-title":"Pten. Vol. 83, Annual Review of Biochemistry","first-page":"641","author":"Worby","year":"2014"},{"issue":"26","key":"10.1016\/j.ijcard.2023.131128_bb0300","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M110.109207","article-title":"MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of fas ligand","volume":"285","author":"Sayed","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijcard.2023.131128_bb0305","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.13494","article-title":"MicroRNA-214 protects against hypoxia\/reoxygenation induced cell damage and myocardial ischemia\/reperfusion injury via suppression of PTEN and Bim1 expression [Internet]","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget."},{"issue":"10","key":"10.1016\/j.ijcard.2023.131128_bb0310","article-title":"Hypoxia induces cardiac fibroblast proliferation and phenotypic switch: A role for caveolae and caveolin-1\/PTEN mediated pathway","volume":"6","author":"Gao","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ijcard.2023.131128_bb0315","doi-asserted-by":"crossref","DOI":"10.2147\/NDT.S297975","article-title":"Mir-195-5p ameliorates cerebral ischemia-reperfusion injury by regulating the pten-akt signaling pathway","volume":"17","author":"Ren","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131128_bb0320","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvp015","article-title":"MicroRNA expression in response to murine myocardial infarction: MiR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue","volume":"82","author":"Roy","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131128_bb0325","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/jcp.22852","article-title":"Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy","volume":"227","author":"Xu","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijcard.2023.131128_bb0330","first-page":"12","article-title":"miR-217 promotes cardiac hypertrophy and dysfunction by targeting PTEN","author":"Nie","year":"2018","journal-title":"Mol. Ther. Nucleic Acids."},{"key":"10.1016\/j.ijcard.2023.131128_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.03.049","article-title":"GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K\/AKT pathway","volume":"226","author":"Wang","year":"2019","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.ijcard.2023.131128_bb0340","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.28596","article-title":"STAT1-avtiviated LINC00961 regulates myocardial infarction by the PI3K\/AKT\/GSK3\u03b2 signaling pathway","volume":"120","author":"Liu","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.ijcard.2023.131128_bb0345","article-title":"Overexpression of lncRNA GAS5 attenuates cardiac fibrosis through regulating PTEN\/MMP-2 signal pathway in mice","volume":"23","author":"Liu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ijcard.2023.131128_bb0350","first-page":"2018","article-title":"Resveratrol inhibits the TGF- \u03b2 1-induced proliferation of cardiac fibroblasts and collagen secretion by downregulating miR-17 in rat","author":"Zhang","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131128_bb0355","article-title":"miR-216a exacerbates TGF-\u03b2-induced myofibroblast transdifferentiation via PTEN\/AKT signaling","volume":"19","author":"Qu","year":"2019","journal-title":"Mol. Med. Rep."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752732300935X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752732300935X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T21:02:17Z","timestamp":1759093337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016752732300935X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":71,"alternative-id":["S016752732300935X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131128","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of miR-195-3p protects against cardiac dysfunction and fibrosis after myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"131128"}}