{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:12:28Z","timestamp":1776395548866,"version":"3.51.2"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004315","name":"GlaxoSmithKline USA Rockville","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ijcard.2023.131395","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T11:01:14Z","timestamp":1695466874000},"page":"131395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Excessive daytime sleepiness, morning tiredness, and prognostic biomarkers in patients with chronic coronary syndrome"],"prefix":"10.1016","volume":"394","author":[{"given":"Maciej","family":"Olszowka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nermin","family":"Hadziosmanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Ljunggren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Denchev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Manolis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey D.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph A.H.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Held","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2023.131395_bb0005","series-title":"Global Health Estimates for 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000\u20132019","author":"World Health Organization","year":"2020"},{"issue":"10258","key":"10.1016\/j.ijcard.2023.131395_bb0010","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0140-6736(20)31404-5","article-title":"Five insights from the global burden of disease study 2019","volume":"396","author":"Abbafati","year":"2020","journal-title":"Lancet."},{"issue":"9438","key":"10.1016\/j.ijcard.2023.131395_bb0015","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet."},{"key":"10.1016\/j.ijcard.2023.131395_bb0020","doi-asserted-by":"crossref","first-page":"E56","DOI":"10.1161\/CIR.0000000000000988","article-title":"Obstructive sleep apnea and cardiovascular disease a scientific statement from the American Heart Association","volume":"144","author":"Yeghiazarians","year":"2021","journal-title":"Circulation."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131395_bb0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1164\/rccm.201808-1509OC","article-title":"Symptom subtypes of obstructive sleep apnea predict incidence of cardiovascular outcomes","volume":"200","author":"Mazzotti","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131395_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/zsaa229","article-title":"Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias","volume":"44","author":"Pack","year":"2021","journal-title":"Sleep."},{"issue":"6","key":"10.1016\/j.ijcard.2023.131395_bb0035","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1016\/j.chest.2021.06.047","article-title":"A validation study of four different cluster analyses of OSA and the incidence of cardiovascular mortality in a Hispanic population","volume":"160","author":"Labarca","year":"2021","journal-title":"Chest."},{"key":"10.1016\/j.ijcard.2023.131395_bb0040","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4065\/mcp.2010.0810","article-title":"Updates on definition, consequences, and management of obstructive sleep apnea concise review for clinicians","volume":"86","author":"Park","year":"2011","journal-title":"Mayo Clin. Proc."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131395_bb0045","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCOUTCOMES.111.964783","article-title":"Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis","volume":"5","author":"Loke","year":"2012","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"issue":"7","key":"10.1016\/j.ijcard.2023.131395_bb0050","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jacc.2016.11.069","article-title":"Sleep apnea: types, mechanisms, and clinical cardiovascular consequences","volume":"69","author":"Javaheri","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131395_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117808","article-title":"Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome","volume":"10","author":"Castro-A\u00f1\u00f3n","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ijcard.2023.131395_bb0060","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/joim.13294","article-title":"Excessive daytime sleepiness, morning tiredness and major adverse cardiovascular events in patients with chronic coronary syndrome","volume":"290","author":"Olszowka","year":"2021","journal-title":"J. Intern. Med."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131395_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007221","article-title":"Excessive daytime sleepiness independently predicts increased cardiovascular risk after myocardial infarction","volume":"7","author":"Xie","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"18","key":"10.1016\/j.ijcard.2023.131395_bb0070","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1056\/NEJMoa1315878","article-title":"Darapladib for preventing ischemic events in stable coronary heart disease","volume":"370","author":"White","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131395_bb0075","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ahj.2010.07.006","article-title":"Study design and rationale for the clinical outcomes of the STABILITY trial (STabilization of atherosclerotic plaque by initiation of darapLadIb TherapY) comparing darapladib versus placebo in patients with coronary heart disease","volume":"160","author":"White","year":"2010","journal-title":"Am. Heart J."},{"issue":"7","key":"10.1016\/j.ijcard.2023.131395_bb0080","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7326\/0003-4819-131-7-199910050-00002","article-title":"Using the Berlin questionnaire to identify patients at risk for the sleep apnea syndrome","volume":"131","author":"Netzer","year":"1999","journal-title":"Ann. Intern. Med."},{"issue":"10289","key":"10.1016\/j.ijcard.2023.131395_bb0085","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/S0140-6736(21)00520-1","article-title":"IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial","volume":"397","author":"Ridker","year":"2021","journal-title":"Lancet."},{"issue":"38","key":"10.1016\/j.ijcard.2023.131395_bb0090","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/eurheartj\/ehy310","article-title":"Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab anti-inflammatory thrombosis outcomes study (CANTOS)","volume":"39","author":"Ridker","year":"2018","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.ijcard.2023.131395_bb0095","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with Canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"19","key":"10.1016\/j.ijcard.2023.131395_bb0100","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in patients with chronic coronary disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"26","key":"10.1016\/j.ijcard.2023.131395_bb0105","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.ijcard.2023.131395_bb0110","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005077","article-title":"Inflammatory biomarkers interleukin-6 and c-reactive protein and outcomes in stable coronary heart disease: experiences from the STABILITY (stabilization of atherosclerotic plaque by initiation of darapladib therapy) trial","volume":"6","author":"Held","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131395_bb0115","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1373\/clinchem.2016.260570","article-title":"Growth differentiation factor 15 predicts all-cause morbidity and mortality in stable coronary heart disease","volume":"63","author":"Hagstr\u00f6m","year":"2017","journal-title":"Clin. Chem."},{"issue":"November","key":"10.1016\/j.ijcard.2023.131395_bb0120","first-page":"1","article-title":"GDF15 and growth control","volume":"9","author":"Emmerson","year":"2018","journal-title":"Front. Physiol."},{"issue":"5","key":"10.1016\/j.ijcard.2023.131395_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.07.033","article-title":"GDF15 is an inflammation-induced central mediator of tissue tolerance","volume":"178","author":"Luan","year":"2019","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ijcard.2023.131395_bb0130","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016396","article-title":"Self-reported sleep duration and napping, cardiac risk factors and markers of subclinical vascular disease: cross-sectional study in older men","volume":"7","author":"Zonoozi","year":"2017","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.ijcard.2023.131395_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/life11040362","article-title":"Evaluation of blood levels of C-reactive protein marker in obstructive sleep apnea: a systematic review, meta-analysis and meta-regression","volume":"11","author":"Imani","year":"2021","journal-title":"Life."},{"key":"10.1016\/j.ijcard.2023.131395_bb0140","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3389\/fimmu.2020.01343","article-title":"Evaluation of serum and plasma Interleukin-6 levels in obstructive sleep apnea syndrome: a Meta-analysis and Meta-regression","volume":"11","author":"Imani","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131395_bb0145","doi-asserted-by":"crossref","first-page":"463","DOI":"10.5665\/sleep.4510","article-title":"Increased inflammatory activity in nonobese patients with coronary artery disease and obstructive sleep apnea","volume":"38","author":"Thunstr\u00f6m","year":"2015","journal-title":"Sleep."},{"issue":"11","key":"10.1016\/j.ijcard.2023.131395_bb0150","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx157","article-title":"CPAP does not reduce inflammatory biomarkers in patients with coronary artery disease and nonsleepy obstructive sleep apnea: a randomized controlled trial","volume":"40","author":"Thunstr\u00f6m","year":"2017","journal-title":"Sleep"},{"key":"10.1016\/j.ijcard.2023.131395_bb0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2015\/807683","article-title":"The correlation of serum growth differentiation Factor-15 level in patients with obstructive sleep apnea","volume":"2015","author":"Sari","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"11","key":"10.1016\/j.ijcard.2023.131395_bb0160","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.5665\/sleep.2202","article-title":"Association between obstructive sleep apnea and elevated levels of type B natriuretic peptide in a community-based sample of women","volume":"35","author":"Ljunggren","year":"2012","journal-title":"Sleep."},{"issue":"8","key":"10.1016\/j.ijcard.2023.131395_bb0165","article-title":"Impact of snoring on the cardiovascular system and its treatment: positive and negative effects of continuous positive airway pressure in sleep apnea","volume":"12","author":"Jayaprakash","year":"2020","journal-title":"Cureus."},{"issue":"7","key":"10.1016\/j.ijcard.2023.131395_bb0170","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00392-010-0140-z","article-title":"Inflammation increases NT-proBNP and the NT-proBNP\/BNP ratio","volume":"99","author":"Jensen","year":"2010","journal-title":"Clin. Res. Cardiol."},{"issue":"3","key":"10.1016\/j.ijcard.2023.131395_bb0175","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5935\/0103-507X.20190060","article-title":"The role of natriuretic peptides in the management, outcomes and prognosis of sepsis and septic shock","volume":"31","author":"Pandompatam","year":"2019","journal-title":"Rev Bras Ter Intensiva."},{"key":"10.1016\/j.ijcard.2023.131395_bb0180","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cca.2016.06.046","article-title":"Biomarkers of cardiovascular stress in obstructive sleep apnea","volume":"460","author":"Maeder","year":"2016","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.ijcard.2023.131395_bb0185","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3390\/cells10040951","article-title":"Targeting inflammatory pathways in cardiovascular disease: the Inflammasome, Interleukin-1, Interleukin-6 and beyond","volume":"10","author":"Libby","year":"2021","journal-title":"Cells."},{"key":"10.1016\/j.ijcard.2023.131395_bb0190","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.sleep.2015.09.018","article-title":"Increased risk of heart failure in women with symptoms of sleep-disordered breathing","volume":"17","author":"Ljunggren","year":"2016","journal-title":"Sleep Med."},{"issue":"8","key":"10.1016\/j.ijcard.2023.131395_bb0195","first-page":"1127","article-title":"Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association?","volume":"31","author":"Kapur","year":"2008","journal-title":"Sleep."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131395_bb0200","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/sleep\/34.4.435","article-title":"Sleep disordered breathing with excessive daytime sleepiness is a risk factor for mortality in older adults","volume":"34","author":"Gooneratne","year":"2011","journal-title":"Sleep."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131395_bb0205","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/rccm.202105-1274OC","article-title":"Sleep apnea\u2013specific hypoxic burden, symptom subtypes, and risk of cardiovascular events and all-cause mortality","volume":"205","author":"Trzepizur","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.ijcard.2023.131395_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.114.000907","article-title":"B-type natriuretic peptides for the prediction of cardiovascular events in patients with stable coronary heart disease: the heart and soul study","volume":"3","author":"Mishra","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.ijcard.2023.131395_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003513","article-title":"Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: a retrospective study","volume":"18","author":"Wallentin","year":"2021","journal-title":"PLoS Med."},{"issue":"16","key":"10.1016\/j.ijcard.2023.131395_bb0220","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/eurheartj\/ehac055","article-title":"Targeted proteomics improves cardiovascular risk prediction in secondary prevention","volume":"43","author":"Nurmohamed","year":"2022","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131395_bb0225","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10741-021-10105-w","article-title":"Biomarkers for the diagnosis and management of heart failure","volume":"27","author":"Castiglione","year":"2022","journal-title":"Heart Fail. Rev."},{"issue":"12","key":"10.1016\/j.ijcard.2023.131395_bb0230","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1515\/cclm-2019-1320","article-title":"Stabilization patterns and variability of hs-CRP, NT-proBNP and ST2 during 1 year after acute coronary syndrome admission: results of the BIOMArCS study","volume":"58","author":"Van Den Berg","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"issue":"2","key":"10.1016\/j.ijcard.2023.131395_bb0235","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ihj.2017.08.005","article-title":"The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease","volume":"70","author":"Gupta","year":"2018","journal-title":"Indian Heart J."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323013888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323013888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T21:04:20Z","timestamp":1759093460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527323013888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":47,"alternative-id":["S0167527323013888"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131395","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excessive daytime sleepiness, morning tiredness, and prognostic biomarkers in patients with chronic coronary syndrome","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"131395"}}