{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:00:04Z","timestamp":1793642404070,"version":"4.5.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ijcard.2023.131426","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:27:30Z","timestamp":1696854450000},"page":"131426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2\/STAT3 signaling"],"prefix":"10.1016","volume":"395","author":[{"given":"Boyu","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koulong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2023.131426_bb0005","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1093\/eurheartj\/ehac430","article-title":"The burden of cardiovascular risk factors: a global perspective","volume":"43","author":"Crea","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2023.131426_bb0010","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart disease and stroke Statistics-2022 update: a report from the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2023.131426_bb0015","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2023.131426_bb0020","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","article-title":"IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR","volume":"104","author":"Krishnamurthy","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2023.131426_bb0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACC review topic of the week","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0030","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1161\/hc3401.095947","article-title":"Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia\/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase","volume":"104","author":"Negoro","year":"2001","journal-title":"Circulation."},{"key":"10.1016\/j.ijcard.2023.131426_bb0035","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pharmthera.2008.08.002","article-title":"The myocardial JAK\/STAT pathway: from protection to failure","volume":"120","author":"Boengler","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijcard.2023.131426_bb0040","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.yjmcc.2011.01.002","article-title":"A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning","volume":"50","author":"Bolli","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0045","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1126\/science.1169660","article-title":"Cell biology. Moonlighting in mitochondria","volume":"323","author":"Myers","year":"2009","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ijcard.2023.131426_bb0050","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak-STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0055","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1128\/MCB.00541-15","article-title":"A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3","volume":"35","author":"Garama","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0060","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00395-010-0124-1","article-title":"Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia\/reperfusion","volume":"105","author":"Boengler","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0065","doi-asserted-by":"crossref","first-page":"532","DOI":"10.7150\/ijbs.15153","article-title":"Mitochondrial Stat3, the need for design thinking","volume":"12","author":"Yang","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ijcard.2023.131426_bb0070","doi-asserted-by":"crossref","first-page":"H827","DOI":"10.1152\/ajpheart.00003.2006","article-title":"The JAK\/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta","volume":"291","author":"Gross","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0075","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1002\/ptr.7347","article-title":"Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: a comprehensive review","volume":"36","author":"Zhang","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ijcard.2023.131426_bb0080","first-page":"262","article-title":"Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K\/Akt signaling pathway in INS-1 cell","volume":"22","author":"Mo","year":"2019","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.ijcard.2023.131426_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118808","article-title":"Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1\/CCR2 axis in diabetic nephropathy","volume":"272","author":"Du","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ijcard.2023.131426_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117653","article-title":"Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling","volume":"252","author":"Chen","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ijcard.2023.131426_bb0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.tox.2011.08.004","article-title":"Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db\/db mice","volume":"290","author":"Park","year":"2011","journal-title":"Toxicology."},{"key":"10.1016\/j.ijcard.2023.131426_bb0100","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1556\/2060.105.2018.2.8","article-title":"Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats","volume":"105","author":"Rajabi","year":"2018","journal-title":"Physiol. Int."},{"key":"10.1016\/j.ijcard.2023.131426_bb0105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.intimp.2016.04.026","article-title":"Loganin inhibits the inflammatory response in mouse 3T3L1 adipocytes and mouse model","volume":"36","author":"Li","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0110","article-title":"Loganin inhibits angiotensin II-induced cardiac hypertrophy through the JAK2\/STAT3 and NF-\u03baB signaling pathways","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ddr.21853","article-title":"Loganin exerts a protective effect on ischemia-reperfusion-induced acute kidney injury by regulating JAK2\/STAT3 and Nrf2\/HO-1 signaling pathways","volume":"83","author":"Huang","year":"2022","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ijcard.2023.131426_bb0120","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/abbs\/gmab007","article-title":"Interleukin 35 protects cardiomyocytes following ischemia\/reperfusion-induced apoptosis via activation of mitochondrial STAT3","volume":"53","author":"Zhou","year":"2021","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.ijcard.2023.131426_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.922484","article-title":"Sinomenine confers protection against myocardial ischemia reperfusion injury by preventing oxidative stress, cellular apoptosis, and inflammation","volume":"13","author":"Xia","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0130","article-title":"Indole-3-Carbinol (I3C) protects the heart from ischemia\/reperfusion injury by inhibiting oxidative stress, inflammation, and cellular apoptosis in mice","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.650055","article-title":"Nicotine causes mitochondrial dynamics imbalance and apoptosis through ROS mediated Mitophagy impairment in cardiomyocytes","volume":"12","author":"Meng","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0175","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","article-title":"Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning","volume":"116","author":"Heusch","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2023.131426_bb0180","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fcvm.2015.00036","article-title":"Pivotal importance of STAT3 in protecting the heart from acute and chronic stress: new advancement and unresolved issues","volume":"2","author":"Zouein","year":"2015","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2023.131426_bb0185","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1050-1738(02)00230-X","article-title":"Role of the JAK-STAT pathway in protection against myocardial ischemia\/reperfusion injury","volume":"13","author":"Bolli","year":"2003","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2023.131426_bb0190","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI0215650","article-title":"What does Stat3 do?","volume":"109","author":"Levy","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2023.131426_bb0195","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ijcard.2023.131426_bb0200","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/aps.2015.136","article-title":"Berberine protects rat heart from ischemia\/reperfusion injury via activating JAK2\/STAT3 signaling and attenuating endoplasmic reticulum stress","volume":"37","author":"Zhao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ijcard.2023.131426_bb0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-016-0543-8","article-title":"Understanding STAT3 signaling in cardiac ischemia","volume":"111","author":"O\u2019Sullivan","year":"2016","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0210","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/bcpt.12164","article-title":"Therapeutic targeting of the Jak\/STAT pathway","volume":"114","author":"Aittom\u00e4ki","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0215","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.0000134921.50377.61","article-title":"Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury","volume":"95","author":"Hilfiker-Kleiner","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2023.131426_bb0220","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fcvm.2019.00150","article-title":"An update on the multifaceted roles of STAT3 in the heart","volume":"6","author":"Harhous","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2023.131426_bb0225","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1083\/jcb.200503021","article-title":"Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin","volume":"172","author":"Ng","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0230","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00395-021-00898-0","article-title":"Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function","volume":"116","author":"Comit\u00e0","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ijcard.2023.131426_bb0235","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mito.2011.08.011","article-title":"Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3","volume":"12","author":"Szczepanek","year":"2012","journal-title":"Mitochondrion."},{"key":"10.1016\/j.ijcard.2023.131426_bb0240","first-page":"19","article-title":"Effects of cardiovascular risk factors on cardiac STAT3","author":"Pipicz","year":"2018","journal-title":"Int. J. Mol. Sci."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323014560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527323014560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:28:33Z","timestamp":1736342913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527323014560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":41,"alternative-id":["S0167527323014560"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131426","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2\/STAT3 signaling","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2023.131426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"131426"}}